Stabilization and inhibition of protein-protein interactions: the 14-3-3 case study

Small-molecule modulation of protein-protein interactions (PPIs) is one of the most exciting but also difficult fields in chemical biology and drug development. As one of the most important "hub" proteins with at least 200-300 interaction partners, the 14-3-3 proteins are an especially fru...

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Veröffentlicht in:	ACS chemical biology Jg. 8; H. 1; S. 27
Hauptverfasser:	Milroy, Lech-Gustav, Brunsveld, Luc, Ottmann, Christian
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 18.01.2013
Schlagworte:	14-3-3 Proteins - antagonists & inhibitors 14-3-3 Proteins - metabolism Diterpenes - chemistry Diterpenes - pharmacology Glycosides - chemistry Glycosides - pharmacology Humans Models, Molecular Protein Binding Protein Stability - drug effects
ISSN:	1554-8937, 1554-8937
Online-Zugang:	Weitere Angaben
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