Influence of oxygenation on the reactivity of ruthenium-thiolato bonds in arene anticancer complexes: insights from XAS and DFT

Thiolate ligand oxygenation is believed to activate cytotoxic half-sandwich [(eta(6)-arene)Ru(en)(SR)](+) complexes toward DNA binding. We have made detailed comparisons of the nature of the Ru-S bond in the parent thiolato complexes and mono- (sulfenato) and bis- (sulfinato) oxygenated species incl...

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Bibliographic Details
Published in:	Journal of the American Chemical Society Vol. 131; no. 37; p. 13355
Main Authors:	Sriskandakumar, Thamayanthy, Petzold, Holm, Bruijnincx, Pieter C A, Habtemariam, Abraha, Sadler, Peter J, Kennepohl, Pierre
Format:	Journal Article
Language:	English
Published:	United States 23.09.2009
Subjects:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism DNA - metabolism Drug Design Electrons Hydrocarbons, Aromatic - chemistry Ligands Models, Molecular Molecular Conformation Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Organometallic Compounds - metabolism Oxygen - chemistry Quantum Theory Ruthenium - chemistry Spectrum Analysis Sulfhydryl Compounds - chemistry X-Rays
ISSN:	1520-5126, 1520-5126
Online Access:	Get more information
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