Unraveling the mechanism of cascade reactions of zincke aldehydes

The thermal pericyclic cascade rearrangement of Zincke aldehydes (5-(dialkylamino)-2,4-pentadienals) to afford Z-α,β,γ,δ-unsaturated amides discovered by the Vanderwal group has been studied in depth using quantum mechanical methods. Two mechanistic possibilities that had previously been put forth t...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 133; no. 11; p. 3895
Main Authors:	Paton, Robert S, Steinhardt, Sarah E, Vanderwal, Christopher D, Houk, K N
Format:	Journal Article
Language:	English
Published:	United States 23.03.2011
Subjects:	Aldehydes - chemistry Hydrogen Bonding Models, Molecular Oxidation-Reduction Quantum Theory
ISSN:	1520-5126, 1520-5126
Online Access:	Get more information
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