An Information Technology Framework for Predictive, Preventive and Personalised Medicine A Use-Case with Hepatocellular Carcinoma

This book explores how PPPM, clinical practice, and basic research could be best served by information technology (IT). A use-case was developed for hepatocellular carcinoma (HCC). The subject was approached with four interrelated tasks: (1) review of clinical practices relating to HCC; (2) propose...

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Main Authors: Berliner, Leonard, Lemke, Heinz U
Format: eBook
Language:English
Published: Cham Springer International Publishing AG 2015
Springer International Publishing
Springer
Edition:1
Series:Advances in Predictive, Preventive and Personalised Medicine
Subjects:
Data Mining and Knowledge Discovery
Health Informatics
Hepatology
Liver
Medicine
Medicine & Public Health
Medicine, Preventive
Oncology
Personalized medicine
Simulation and Modeling
ISBN:3319121650, 9783319121659
ISSN:2211-3495, 2211-3509
Online Access:Get full text
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Abstract This book explores how PPPM, clinical practice, and basic research could be best served by information technology (IT). A use-case was developed for hepatocellular carcinoma (HCC). The subject was approached with four interrelated tasks: (1) review of clinical practices relating to HCC; (2) propose an IT system relating to HCC, including clinical decision support and research needs; (3) determine how a clinical liver cancer center can contribute; and, (4) examine the enhancements and impact that the first three tasks will have on the management of HCC. An IT System for Personalized Medicine (ITS-PM) for HCC will provide the means to identify and determine the relative value of the wide number of variables, including clinical assessment of the patient -- functional status, liver function, degree of cirrhosis, and comorbidities; tumor biology, at a molecular, genetic and anatomic level; tumor burden and individual patient response; medical and operative treatments and their outcomes.
AbstractList This book explores how PPPM, clinical practice, and basic research could be best served by information technology (IT). A use-case was developed for hepatocellular carcinoma (HCC). The subject was approached with four interrelated tasks: (1) review of clinical practices relating to HCC; (2) propose an IT system relating to HCC, including clinical decision support and research needs; (3) determine how a clinical liver cancer center can contribute; and, (4) examine the enhancements and impact that the first three tasks will have on the management of HCC. An IT System for Personalized Medicine (ITS-PM) for HCC will provide the means to identify and determine the relative value of the wide number of variables, including clinical assessment of the patient -- functional status, liver function, degree of cirrhosis, and comorbidities; tumor biology, at a molecular, genetic and anatomic level; tumor burden and individual patient response; medical and operative treatments and their outcomes.
Author Lemke, Heinz U
Berliner, Leonard
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PublicationSeriesTitle Advances in Predictive, Preventive and Personalised Medicine
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PublicationYear 2015
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Springer International Publishing
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Snippet This book explores how PPPM, clinical practice, and basic research could be best served by information technology (IT). A use-case was developed for...
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SubjectTerms Data Mining and Knowledge Discovery
Health Informatics
Hepatology
Liver
Medicine
Medicine & Public Health
Medicine, Preventive
Oncology
Personalized medicine
Simulation and Modeling
Subtitle A Use-Case with Hepatocellular Carcinoma
TableOfContents Intro -- What This Book Series is About -- Current Healthcare: What is Behind the issue? -- Advanced Healthcare Tailored to the Person: What is Beyond the Issue? -- Why Integrative Medical Approach by PPPM as the Medicine of the Future? -- About The Editor -- Foreword -- Preface -- Contents -- Contributors -- List of Abbreviations -- Chapter 1 -- Introduction -- 1.1 Introduction -- 1.1.1 Predictive, Preventive and Personalized Medicine -- 1.1.2 PPPM and Evidence-Based Medicine -- 1.1.3 Personalized Medicine, Biomarkers, and Information Technology -- 1.1.4 Clinical Liver Tumor Treatment Program as Use-Case -- Conclusion -- References -- Chapter 2 -- The Digital Patient Model and Model Guided Therapy -- 2.1 Introduction -- 2.1.1 Therapy Imaging and Model Management System -- 2.1.2 Digital Patient Model -- 2.1.3 Multi-Entity Bayesian Network (MEBN) -- 2.1.4 UnBBayes -- Conclusion -- References -- Chapter 3 -- Hepatocellular Carcinoma and Patient Assessment -- 3.1 Introduction -- 3.1.1 Pathology of Hepatocellular Carcinoma -- 3.1.2 Clinical Liver Cancer Center -- 3.1.3 Screening for Hepatocellular Carcinoma -- 3.1.4 Diagnosis of Hepatocellular Carcinoma -- 3.1.4.1 Liver Lesions &gt -- 2 cm in Diameter -- 3.1.4.2 Liver Lesions 1-2 cm in Diameter -- 3.1.4.3 Liver Lesions &lt -- 1 cm in Diameter -- 3.1.5 Staging of Hepatocellular Carcinoma -- 3.1.6 Functional Assessment -- 3.1.7 Construction of Database -- Conclusion -- References -- Chapter 4 -- Imaging in Hepatocellular Carcinoma: Radiologic Assessment -- 4.1 Introduction -- 4.1.1 Diagnosis of HCC -- 4.1.2 New Diagnostic Tools -- 4.1.2.1 Diffusion-Weighted Imaging (DWI) -- 4.1.2.2 Hepatospecific Contrast Agents for MR -- 4.1.3 Therapeutic Algorithm and Treatment Planning -- 4.1.3.1 Very Early Stage -- 4.1.3.2 Early Stage -- 4.1.3.3 Intermediate Stage -- 4.1.3.4 Advanced Stage
9.1.1 Mechanisms and Instrumentation for RFA -- 9.1.2 Pre-Procedure Requirements -- 9.1.3 The Procedure -- 9.1.4 Applicability -- 9.1.5 Complications -- 9.1.6 Follow-Up -- 9.1.7 Results of RFA and Other Forms of Ablation Therapy -- Conclusion -- References -- Chapter 10 -- Minimally Invasive Therapies for Hepatocellular Cancer: Catheter-Directed Therapies -- 10.1 Introduction -- 10.1.1 Transarterial Chemoembolization forHepatocellular Carcinoma -- 10.1.1.1 Iodized Poppy Seed Oil -- 10.1.1.2 Drug-Eluting Beads -- 10.1.2 Indications for TACE -- 10.1.3 Combination of RFA and TACE -- 10.1.4 Chemoembolization and Portal Vein Embolization Prior to Surgical resection -- 10.1.5 Sorafenib and DEB-TACE -- Conclusion -- References -- Chapter 11 -- Radiation Oncology in the Treatment of Hepatocellular Carcinoma -- 11.1 Introduction -- 11.1.1 External Beam Radiotherapy in the Treatment of Hepatocellular Carcinoma -- 11.1.2 Stereotactic Body Radiotherapy -- 11.1.3 Radioembolization -- Conclusion -- References -- Chapter 12 -- Design of an IT System for Hepatocellular Carcinoma -- 12.1 Introduction -- 12.1.1 ITS-PM: Organization and Architecture -- 12.1.1.1 Requirements for an ITS-PM -- 12.1.2 Clinical and Research Components -- 12.1.2.1 Defining the Requirements of the ITS-PM -- Conclusion -- References -- Chapter 13 -- Outlook and Expert Recommendations for Predictive, Preventive and Personalized Medicine and Hepatocellular Carcinoma -- 13.1 Introduction -- 13.2 Building on the Barcelona Clinic Liver Cancer Staging System -- 13.2.1 Enhanced Screening and "Shift to the Left" -- 13.2.2 Possible Expanded Role of Targeted Therapies -- 13.2.3 Improved Outcomes with Further Personalized Approach -- 13.3 New Algorithms -- Conclusion -- References -- Index
4.1.4 Post-Treatment Evaluation -- 4.1.5 Electronic Medical Records and Radiological Data -- Conclusion -- References -- Chapter 5 -- Imaging in Hepatocellular Carcinoma: PET/CT -- 5.1 Introduction -- 5.1.1 Pharmacology -- 5.1.2 Role of PET Imaging in Oncology -- 5.1.2.1 Diagnosis -- 5.1.2.2 Response to Treatment -- 5.1.3 PET/CT in Guiding Ablation Therapies to the Liver -- 5.1.3.1 Metastatic Liver Disease -- 5.1.3.2 Hepatocellular Cancer -- 5.1.3.3 Pre-Operative Evaluation -- 5.1.3.4 Response to Treatment -- Conclusion -- References -- Chapter 6 -- Personalized Chemotherapy for Hepatocellular Carcinoma -- 6.1 Introduction -- 6.1.1 Preventative Risk Factors in Hepatocellular Carcinoma -- 6.1.2 Discussion of Molecular/Genetic Etiology of HCC -- 6.1.3 Staging and Personalized Patient Evaluation in Hepatocellular Carcinoma -- 6.1.4 Targeted and Predictive Treatment in Hepatocellular Carcinoma -- 6.1.4.1 Monotherapy: Doxorubicin -- 6.1.4.2 Molecular Targeted Therapy: Sorafenib -- 6.1.5 Personalized Recommendations-Chemotherapy for Hepatocellular Carcinoma -- Conclusion -- References -- Chapter 7 -- Surgical Treatment for Hepatocellular Carcinoma -- 7.1 Introduction -- 7.1.1 Surgical Resection -- 7.1.2 Surgical Resection Techniques -- 7.1.3 Liver Transplantation -- 7.1.4 Down-staging and Bridging Therapies -- 7.1.5 Living vs. Deceased Liver Donor -- Conclusion -- References -- Chapter 8 -- Minimally Invasive Therapies for Hepatocellular Cancer: Ablation Technologies -- 8.1 Introduction -- 8.1.1 Introduction to Tumor Ablation -- 8.1.2 Forms of Ablation -- 8.1.3 Radiofrequency Ablation -- 8.1.4 Electromagnetic Radiation -- 8.1.4.1 Laser Therapy -- 8.1.4.2 Microwave Ablation -- 8.1.5 Cryoablation -- 8.1.6 Irreversible Electroporation -- Conclusion -- Chapter 9 -- Minimally Invasive Therapies for Hepatocellular Cancer: Ablation Therapies -- 9.1 Introduction
Title An Information Technology Framework for Predictive, Preventive and Personalised Medicine
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