Development of carbohydrate-based scaffolds for restricted presentation of recognition groups. Extension to divalent ligands and implications for the structure of dimerized receptors

The solution structure of glycosyl amides has been studied by using NMR. A strong preference is displayed by tertiary aromatic glycosyl amides for E-anti structures in contrast with secondary aromatic glycosyl amides where Z-anti structures predominate. The structural diversity displayed by these cl...

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Bibliographic Details
Published in:	Journal of organic chemistry Vol. 68; no. 14; pp. 5692 - 5704
Main Authors:	Murphy, PV, Bradley, H, Tosin, M, Pitt, N, Fitzpatrick, GM, Glass, WK
Format:	Journal Article
Language:	English
Published:	WASHINGTON Amer Chemical Soc 11.07.2003
Subjects:	Amides - chemical synthesis Amides - pharmacology Amino Sugars - chemical synthesis Amino Sugars - pharmacology Carbohydrates - chemistry Chemistry Chemistry, Organic Dimerization Drug Design Ligands Magnetic Resonance Spectroscopy Molecular Structure Physical Sciences Protein Binding - drug effects Science & Technology GLYCOSYL AZIDES DESIGN PEPTIDOMIMETICS POTENT LECTIN BETA-D-GLUCOSE BIOLOGICAL EVALUATION INHIBITORS BINDING AMIDES
ISSN:	0022-3263, 1520-6904
Online Access:	Get more information
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