Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-analysis

Immune checkpoint inhibitors (ICIs) are now a mainstay of cancer treatment. Although rare, fulminant and fatal toxic effects may complicate these otherwise transformative therapies; characterizing these events requires integration of global data. To determine the spectrum, timing, and clinical featu...

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Veröffentlicht in:	JAMA oncology Jg. 4; H. 12; S. 1721
Hauptverfasser:	Wang, Daniel Y, Salem, Joe-Elie, Cohen, Justine V, Chandra, Sunandana, Menzer, Christian, Ye, Fei, Zhao, Shilin, Das, Satya, Beckermann, Kathryn E, Ha, Lisa, Rathmell, W Kimryn, Ancell, Kristin K, Balko, Justin M, Bowman, Caitlin, Davis, Elizabeth J, Chism, David D, Horn, Leora, Long, Georgina V, Carlino, Matteo S, Lebrun-Vignes, Benedicte, Eroglu, Zeynep, Hassel, Jessica C, Menzies, Alexander M, Sosman, Jeffrey A, Sullivan, Ryan J, Moslehi, Javid J, Johnson, Douglas B
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.12.2018
Schlagworte:	Antineoplastic Agents, Immunological - adverse effects Databases, Factual - statistics & numerical data Drug-Related Side Effects and Adverse Reactions - epidemiology Drug-Related Side Effects and Adverse Reactions - mortality Genes, cdc - drug effects Genes, cdc - immunology Humans Immunologic Factors - adverse effects Immunotherapy - adverse effects Incidence Neoplasms - drug therapy Neoplasms - mortality Neoplasms - therapy Pharmacovigilance Protein Kinase Inhibitors - adverse effects Retrospective Studies
ISSN:	2374-2445, 2374-2445
Online-Zugang:	Weitere Angaben
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