Cu(II)-Catalyzed Decarboxylative (4+2) Annulation of Coumarin-3-Carboxylic Acids with In Situ Generated α,β-Unsaturated Carbonyl Compounds from tert-Propargylic Alcohols

Cu(II)-catalyzed decarboxylative oxidative (4 + 2) annulation of coumarin-3-carboxylic acids with tert-propargylic alcohols, via the in situ generated alpha,beta-unsaturated carbonyl compounds by the Meyer-Schuster rearrangement, has been developed. This protocol involving indirect C-H functionaliza...

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Veröffentlicht in:Organic letters Jg. 25; H. 19; S. 3397 - 3401
Hauptverfasser: Shankar, Mallepalli, Swamy, K. C. Kumara
Format: Journal Article
Sprache:Englisch
Veröffentlicht: WASHINGTON Amer Chemical Soc 19.05.2023
Schlagworte:
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
CATALYZED OXIDATIVE ANNULATION
INDOLIZINES
MICHAEL
ALKYNES
C-H ACTIVATION
DERIVATIVES
COUMARINS
BENZOIC-ACIDS
ISSN:1523-7060, 1523-7052, 1523-7052
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Zusammenfassung:Cu(II)-catalyzed decarboxylative oxidative (4 + 2) annulation of coumarin-3-carboxylic acids with tert-propargylic alcohols, via the in situ generated alpha,beta-unsaturated carbonyl compounds by the Meyer-Schuster rearrangement, has been developed. This protocol involving indirect C-H functionalization offers access to diverse naphthochromenone architectures with good to excellent yields.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/acs.orglett.3c00925