Real-Time Biosensor Platform Based on Novel Sandwich Graphdiyne for Ultrasensitive Detection of Tumor Marker

Realization of a highly sensitive analysis and sensing platform is important for early-stage tumor diagnosis. In this work, a self-powered biosensor with a novel sandwich graphdiyne (SGDY) combined with an aptamer-specific recognition function was developed to sensitively and accurately detect tumor...

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Bibliographic Details
Published in:Analytical chemistry (Washington) Vol. 94; no. 49; p. 16980
Main Authors: Xu, Jing, Liu, Yinbing, Huang, Ke-Jing, Hou, Yang-Yang, Sun, Xiaoxuan, Li, Jiaqiang
Format: Journal Article
Language:English
Published: United States 13.12.2022
Subjects:
Biomarkers, Tumor
Biosensing Techniques - methods
Electrochemical Techniques
Humans
Limit of Detection
MicroRNAs - analysis
Neoplasms - diagnosis
ISSN:1520-6882, 1520-6882
Online Access:Get more information
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Summary:Realization of a highly sensitive analysis and sensing platform is important for early-stage tumor diagnosis. In this work, a self-powered biosensor with a novel sandwich graphdiyne (SGDY) combined with an aptamer-specific recognition function was developed to sensitively and accurately detect tumor markers. Results indicated that the detection limits of microRNA (miRNA)-21 and miRNA-141 were 0.15 and 0.30 fM (S/N = 3) in the linear range of 0.05-10000 and 1-10000 fM, respectively. The newly designed platform has great promise for early-stage tumor diagnosis.
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ISSN:1520-6882
1520-6882
DOI:10.1021/acs.analchem.2c04278