Arabinoxylan from Mucilage of Tomatoes (Solanum lycopersicum L.): Structure and Antinociceptive Effect in Mouse Models

Tomato is a known functional food due to its content of bioactive compounds. Herein, polysaccharides were extracted from mucilage of tomatoes, and a purified fraction (PTOK) was analyzed by sugar composition, methylation, and NMR spectroscopy analysis. The results showed the presence of an arabinoxy...

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Vydané v:Journal of agricultural and food chemistry Ročník 64; číslo 6; s. 1239 - 1244
Hlavní autori: do Nascimento, Georgia Erdmann, Baggio, Cristiane H, Werner, Maria Fernanda de Paula, Iacomini, Marcello, Cordeiro, Lucimara M C
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 17.02.2016
Predmet:
Analgesics - administration & dosage
Analgesics - chemistry
Animals
Disease Models, Animal
Humans
Lycopersicon esculentum - chemistry
Mice
Pain - drug therapy
Plant Extracts - administration & dosage
Plant Extracts - chemistry
Polysaccharides - administration & dosage
Polysaccharides - chemistry
Xylans - administration & dosage
Xylans - chemistry
arabinoxylan
Solanum lycopersicum L
tomato mucilage
antinociceptive activity
ISSN:1520-5118
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Abstract Tomato is a known functional food due to its content of bioactive compounds. Herein, polysaccharides were extracted from mucilage of tomatoes, and a purified fraction (PTOK) was analyzed by sugar composition, methylation, and NMR spectroscopy analysis. The results showed the presence of an arabinoxylan, having (1→4)-linked β-d-Xylp units in the main chain, which carried a low proportion of branching (∼5.6%), at O-2 and O-3 position, with side chains constituted by single Araf or Xylp units. Intraperitoneal administration of the arabinoxylan in mice significantly reduced the number of abdominal constrictions induced by 0.6% acetic acid and the inflammatory phase of nociception induced by 2.5% formalin, indicating that it had an antinociceptive effect on inflammatory pain models, amplifying the biological role displayed by arabinoxylans in the diet. Furthermore, this study reports the presence of an arabinoxylan in a dicotyledon plant, and also it is the first study of polysaccharides from mucilage of tomatoes.
AbstractList Tomato is a known functional food due to its content of bioactive compounds. Herein, polysaccharides were extracted from mucilage of tomatoes, and a purified fraction (PTOK) was analyzed by sugar composition, methylation, and NMR spectroscopy analysis. The results showed the presence of an arabinoxylan, having (1→4)-linked β-d-Xylp units in the main chain, which carried a low proportion of branching (∼5.6%), at O-2 and O-3 position, with side chains constituted by single Araf or Xylp units. Intraperitoneal administration of the arabinoxylan in mice significantly reduced the number of abdominal constrictions induced by 0.6% acetic acid and the inflammatory phase of nociception induced by 2.5% formalin, indicating that it had an antinociceptive effect on inflammatory pain models, amplifying the biological role displayed by arabinoxylans in the diet. Furthermore, this study reports the presence of an arabinoxylan in a dicotyledon plant, and also it is the first study of polysaccharides from mucilage of tomatoes.
Author Baggio, Cristiane H
Werner, Maria Fernanda de Paula
do Nascimento, Georgia Erdmann
Iacomini, Marcello
Cordeiro, Lucimara M C
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  surname: Iacomini
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  fullname: Cordeiro, Lucimara M C
  organization: Departamento de Bioquı́mica e Biologia Molecular, Universidade Federal do Paraná , CP 19.046, CEP 81.531-980 Curitiba, PR, Brazil
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Solanum lycopersicum L
tomato mucilage
antinociceptive activity
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SubjectTerms Analgesics - administration & dosage
Analgesics - chemistry
Animals
Disease Models, Animal
Humans
Lycopersicon esculentum - chemistry
Mice
Pain - drug therapy
Plant Extracts - administration & dosage
Plant Extracts - chemistry
Polysaccharides - administration & dosage
Polysaccharides - chemistry
Xylans - administration & dosage
Xylans - chemistry
Title Arabinoxylan from Mucilage of Tomatoes (Solanum lycopersicum L.): Structure and Antinociceptive Effect in Mouse Models
URI https://www.ncbi.nlm.nih.gov/pubmed/26824871
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