Novel Soy β-Conglycinin Core-Shell Nanoparticles As Outstanding Ecofriendly Nanocarriers for Curcumin

The development of high-performance nanocarriers for nutraceuticals or drugs has become one of the topical research subjects in the functional food fields. In this work, we for the first time propose a novel and ecofriendly process to obtain a kind of nanostructured soy β-conglycinin (β-CG; a major...

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Published in:Journal of agricultural and food chemistry Vol. 67; no. 22; p. 6292
Main Authors: Liu, Ling-Ling, Liu, Peng-Zhan, Li, Xiu-Ting, Zhang, Ning, Tang, Chuan-He
Format: Journal Article
Language:English
Published: United States 05.06.2019
Subjects:
Antigens, Plant - chemistry
Curcumin - chemistry
Drug Carriers - chemistry
Drug Compounding
Drug Delivery Systems - instrumentation
Drug Delivery Systems - methods
Globulins - chemistry
Glycine max - chemistry
Hydrophobic and Hydrophilic Interactions
Nanoparticles - chemistry
Particle Size
Seed Storage Proteins - chemistry
Solubility
Soybean Proteins - chemistry
nanocarrier
soy β-conglycinin
core−shell nanostructure
reassembly
disassembly
curcumin
ISSN:1520-5118, 1520-5118
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Summary:The development of high-performance nanocarriers for nutraceuticals or drugs has become one of the topical research subjects in the functional food fields. In this work, we for the first time propose a novel and ecofriendly process to obtain a kind of nanostructured soy β-conglycinin (β-CG; a major soy storage globulin) as outstanding nanocarriers for poorly soluble bioactives (e.g., curcumin), by a urea-assisted disassembly and reassembly strategy. At urea concentrations > 4 M, the structure of β-CG gradually dissociated into its separate subunits (α, α', and β) and even denatured (depending on the type of subunits); after dialysis to remove urea, the dissociated subunits would reassemble into a kind of core-shell nanostructured particles, in which aggregated β-subunits acted as the core while the shell layer was mainly composed of α- and α'-subunits. The core-shell nanoparticles were favorably formed at protein concentrations of 1.0-2.0 wt %. Curcumin crystals were directly introduced into the β-CG solution at high urea concentrations (e.g., 8 M) and would preferentially interact with the denatured β-subunits. As a consequence, almost all of the curcumin molecules were encapsulated in the core part of the reassembled core-shell nanoparticles. The loading amount of curcumin in these nanoparticles could reach 18 g of curcumin per 100 g of protein, which far exceeds those reported previously. The encapsulated curcumin exhibited a high water solubility, extraordinary thermal stability, and improved bioaccessibility, as well as a sustained release behavior. The findings provide a novel strategy to fabricate a kind of high-encapsulation-performance, organic solvent-free, and biocompatible nanocarrier for hydrophobic nutraceuticals and drugs.
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ISSN:1520-5118
1520-5118
DOI:10.1021/acs.jafc.8b05822