Base-Dependent Divergent Annulation of 4-Chloro-3-formylcoumarin and Tetrahydroisoquinoline: Application to the Synthesis of Isolamellarins and Hydroxypyrrolones

A series of pyrrolo[2,1-a]isoquinoline and coumarin-fused pentacyclic derivatives were synthesized via base-mediated divergent annulation of 4-chloro-3-formylcoumarin and tetrahydroisoquinoline as a key step. This method was then extended to the preparation of isolamellarins A and B (isolamellarin G...

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Bibliographic Details

Published in:	Journal of organic chemistry Vol. 84; no. 6; pp. 3662 - 3670
Main Authors:	Vyasamudri, Sameer, Yang, Ding-Yah
Format:	Journal Article
Language:	English
Published:	WASHINGTON Amer Chemical Soc 15.03.2019
Subjects:	Chemistry Chemistry, Organic Physical Sciences Science & Technology LAMELLARIN-ALPHA 20-SULFATE CHILENINE INHIBITORS DERIVATIVES ALKALOIDS
ISSN:	0022-3263, 1520-6904, 1520-6904
Online Access:	Get more information
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