Effects of Food and Omeprazole on a Novel Formulation of Super Bioavailability Itraconazole in Healthy Subjects

To address the limited bioavailability and intolerance of the conventional itraconazole (ITZ) formulations, a new formulation labeled per io vailability (SUBA) itraconazole has been developed; however, the specific effects of food and gastric pH are unknown. This study evaluated the pharmacokinetic...

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Vydáno v:	Antimicrobial agents and chemotherapy Ročník 62; číslo 12
Hlavní autoři:	Lindsay, Julian, Mudge, Stuart, Thompson, 3rd, George R
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.12.2018
Témata:	Adult Antifungal Agents - blood Antifungal Agents - pharmacokinetics Area Under Curve Biological Availability Capsules Cross-Over Studies Drug Administration Schedule Eating Fasting Food-Drug Interactions Half-Life Healthy Volunteers Humans Itraconazole - blood Itraconazole - pharmacokinetics Omeprazole - administration & dosage Patient Safety Proton Pump Inhibitors - administration & dosage pharmacokinetics itraconazole antifungal agents
ISSN:	1098-6596, 1098-6596
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