Defect Engineering Enables Synergistic Action of Enzyme-Mimicking Active Centers for High-Efficiency Tumor Therapy

Perusing redox nanozymes capable of disrupting cellular homeostasis offers new opportunities to develop cancer-specific therapy, but remains challenging, because most artificial enzymes lack enzyme-like scale and configuration. Herein, for the first time, we leverage a defect engineering strategy to...

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Bibliographic Details
Published in:Journal of the American Chemical Society Vol. 143; no. 23; p. 8855
Main Authors: Yu, Bin, Wang, Wei, Sun, Wenbo, Jiang, Chunhuan, Lu, Lehui
Format: Journal Article
Language:English
Published: United States 16.06.2021
Subjects:
Humans
Iron - chemistry
Iron - metabolism
Lasers
Molybdenum - chemistry
Molybdenum - metabolism
Neoplasms - metabolism
Neoplasms - therapy
Oxidation-Reduction
Oxides - chemistry
Oxides - metabolism
Particle Size
ISSN:1520-5126, 1520-5126
Online Access:Get more information
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Summary:Perusing redox nanozymes capable of disrupting cellular homeostasis offers new opportunities to develop cancer-specific therapy, but remains challenging, because most artificial enzymes lack enzyme-like scale and configuration. Herein, for the first time, we leverage a defect engineering strategy to develop a simple yet efficient redox nanozyme by constructing enzyme-mimicking active centers and investigated its formation and catalysis mechanism thoroughly. Specifically, the partial Fe doping in MoO (donated as Fe-MoO ) was demonstrated to activate structure reconstruction with abundant defect site generation, including Fe substitution and oxygen vacancy (OV) defects, which significantly enable the binding capacity and catalytic activity of Fe-MoO nanozymes in a synergetic fashion. More intriguingly, plenty of delocalized electrons appear due to Fe-facilitated band structure reconstruction, directly contributing to the remarkable surface plasmon resonance effect in the near-infrared (NIR) region. Under NIR-II laser irradiation, the designed Fe-MoO nanozymes are able to induce substantial disruption of redox and metabolism homeostasis in the tumor region via enzyme-mimicking cascade reactions, thus significantly augmenting therapeutic effects. This study that takes advantage of defect engineering offers new insights into developing high-efficiency redox nanozymes.
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ISSN:1520-5126
1520-5126
DOI:10.1021/jacs.1c03510