Medical Immunology, 7th Edition
This seventh edition of Medical Immunology, now in a full-color presentation, continues to provide a succinct clinical review of the human response to infection while being firmly grounded in science. The authors, distinguished and experienced educators, have been able to anticipate readers’ concept...
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| Format: | E-Book |
| Sprache: | Englisch |
| Veröffentlicht: |
Milton
CRC Press
08.10.2019
Taylor & Francis Group |
| Ausgabe: | 7 |
| Schlagworte: | |
| ISBN: | 9780367224882, 1032087773, 9781032087771, 0367224887 |
| Online-Zugang: | Volltext |
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Inhaltsangabe:
- Bibliography -- 25. Transplantation immunology -- Introduction -- Donor-recipient matching -- Graft rejection -- Immunosuppression -- Graft-versus-host disease -- Road to tolerance: Stem cells and chimerism -- Bibliography -- 26. Tumor immunology -- Introduction -- Closing remarks -- Bibliography -- 27. Lymphocyte and plasma cell malignancies -- Introduction -- B-Cell dyscrasias -- Leukemias and lymphomas -- Bibliography -- 28. Diagnosis of immune deficiency diseases -- Introduction -- Clinical and laboratory diagnosis of immune disorders -- Laboratory assessment of immunity -- Diagnostic testing using molecular genetics -- Bibliography -- 29. Primary immunodeficiency diseases -- Introduction -- Immunodeficiencies affecting cellular and humoral immunity -- Combined immunodeficiency with associated or syndromic features -- Predominantly antibody deficiencies -- Gammaglobulin replacement therapy -- Diseases of immune dysregulation -- Congenital phagocytic defects -- Defects in intrinsic and innate immunity -- Phenocopies of primary immune deficiency -- Bibliography -- 30. AIDS and other acquired immunodeficiencies -- Introduction -- Secondary immunodeficiencies -- HIV infection and AIDS -- Bibliography -- Index
- Introduction -- Innate immunity -- Natural antibodies -- Adaptive immunity -- Immune deficiency syndromes for study of immune defenses against human infections -- Escape from immune response -- Abnormal consequences of the immune response -- Epilogue -- Bibliography -- 15. Diagnostic applications of immunology -- Introduction -- Serological assays -- Classical assays -- Tests based on Immunofluorescence -- Monoclonal antibody-based assays -- Flow cytometry -- Cell isolation -- Immunohistochemistry -- Highly sensitive immunoassays -- Enzyme immunoassay -- Evaluation of cellular immune responses -- Laboratory tests for assessment of lymphocyte function ex vivo -- Laboratory tests for assessment of lymphocyte function in vivo -- Laboratory tests for assessment of phagocytic cell function -- Bibliography -- 16. Tolerance and autoimmunity -- Definition and general characteristics of tolerance -- Mechanisms of tolerance: Clonal deletion -- Mechanisms of tolerance: Clonal anergy -- Acquired tolerance -- Experimental approaches to definition of mechanisms of lymphocyte tolerance -- T-lymphocyte tolerance models -- Mucosal tolerance -- Termination of tolerance -- Autoimmunity -- Classification of autoimmune diseases -- Pathophysiology of autoimmune diseases -- Pathogenic factors involved in onset of autoimmune diseases -- Environmental factors -- Animal models of autoimmunity -- Immunomodulation in treatment of autoimmune diseases -- Bibliography -- 17. Organ-specific autoimmune diseases -- Introduction -- Autoimmune diseases of the thyroid gland -- Addison's disease (chronic primary hypoadrenalism) -- Autoimmune polyglandular syndromes -- Autoimmune diabetes mellitus -- Acanthosis nigricans -- Autoimmune diseases of the gastrointestinal tract and liver -- Autoimmune diseases of the neuromuscular systems -- Bibliography -- 18. Systemic lupus erythematosus
- Cover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Contents -- Preface -- Acknowledgments -- Editor -- Contributors -- 1. Introduction -- Historical overview -- General concepts -- Cells of immune system -- Antigens and antibodies -- Lymphocytes and cell-mediated immunity -- Self versus non-self keep non-self discrimination -- General overview -- Immunology and medicine -- 2. Leukocytes and lymphoid tissues: The framework of the immune system -- Introduction -- Cells of immune system -- Lymphoid organs and tissues -- Lymphocyte traffic -- Bibliography -- 3. Major histocompatibility complex -- Introduction -- Major histocompatibility complex genes -- MHC protein structure -- MHC protein functions -- HLA disease associations -- Bibliography -- 4. Adaptive immune response: Antigens, lymphocytes, and accessory cells -- Introduction -- Antigenicity and immunogenicity -- Activation of humoral immune system -- T-dependent and T-independent antigens -- Induction of immune response -- Bibliography -- 5. Immunoglobulins: Structure and diversity -- Introduction -- Structure of immunoglobulin G -- Structural and antigenic heterogeneity of heavy and light chains -- Immunoglobulin regions and domains -- Antibody-combining site -- Immunoglobulin M: A polymeric molecule -- Immunoglobulin A: A molecularly heterogeneous immunoglobulin -- Minor immunoglobulin classes: IgD and IgE -- Bibliography -- 6. Immunoglobulins: Metabolism and biological properties -- Immunoglobulin biosynthesis -- Immunoglobulin synthetic and catabolic rates -- Biological properties of immunoglobulins -- Bibliography -- 7. Genetics of immunoglobulins: Ontogenic, biological, and clinical implications -- Introduction -- Immunoglobulin gene rearrangement -- Genetic basis of antibody diversity -- Antigenic determinants of immunoglobulin molecules -- Allelic exclusion
- GM allotypes and Igg subclass concentrations -- Immunoglobulin allotypes, immune response, and diseases -- Bibliography -- 8. Antigen-antibody reactions -- General characteristics of the antigen-antibody reaction -- Specific types of antigen-antibody reactions -- Biological consequences of the antigen-antibody reaction -- Bibliography -- 9. The complement system in health and disease -- Introduction -- Complement activation mechanisms and pathways -- Alternative complement pathway -- Lectin pathway of complement activation -- Late steps of complement activation -- Complement receptors -- Regulation of complement activation -- Functions of the complement system -- Complement and disease -- Complement levels in disease -- Microbial anticomplementary mechanisms -- Bibliography -- 10. Monocyte and lymphocyte membrane markers: Ontogeny and clinical significance -- Introduction -- Hematopoietic stem cells -- Monocytes -- Dendritic cells -- Lymphocytes -- NK-cell inhibitory markers -- Unconventional T cells -- T lymphocyte markers -- B cells -- Bibliography -- 11. Cell-mediated immunity -- Introduction -- T-cell activation -- Immune memory -- Regulation of the immune response -- Concluding remarks -- Bibliography -- 12. Adaptive humoral immunity and immunoprophylaxis -- Introduction -- Overview of induction of humoral immune response -- Primary immune response -- Secondary or anamnestic response -- Fate of antigens on primary and secondary responses -- Mucosal humoral immune response -- Passive immunization -- Immunoprophylaxis -- Bibliography -- 13. Phagocytic cells and their functions -- Introduction -- Physiology of polymorphonuclear leukocytes -- Physiology of monocyte/macrophage -- Phagocytic cell activation and inflammation -- Laboratory evaluation of phagocytic function -- Bibliography -- 14. Anti-infectious innate and adaptive immune responses
- Introduction -- Clinical manifestations -- Immunological abnormalities in systemic lupus erythematosus -- Pathogenesis of SLE -- Treatment -- Bibliography -- 19. Rheumatoid arthritis -- Introduction -- Clinical and pathological aspects of rheumatoid arthritis -- Autoantibodies in rheumatoid arthritis -- Genetic factors in rheumatoid arthritis -- Immunological factors in pathogenesis of rheumatoid arthritis -- Summary overview of pathogenesis of rheumatoid arthritis -- Therapy -- Bibliography -- 20. Overview of hypersensitivity -- Introduction -- Type I hypersensitivity reactions (IgE-mediated hypersensitivity, immediate hypersensitivity) -- Cytotoxic reactions (type II hypersensitivity) -- Immune complex-induced hypersensitivity reactions (type III hypersensitivity) -- Delayed (type IV) hypersensitivity reactions -- Bibliography -- 21. IgE-mediated (immediate) hypersensitivity -- Introduction -- Major clinical expressions -- Pathogenesis -- Diagnostic tests for immediate hypersensitivity -- Prevention and therapy -- Bibliography -- 22. Immunohematology -- Introduction: Blood groups -- Serological principles of blood transfusion -- Blood transfusion reactions -- Hemolytic anemias -- Autoimmune hematological disorders (AIHDs) -- Autoimmune thrombocytopenias -- Autoimmune neutropenia -- Autoimmune coagulopathies -- Bibliography -- 23. Pathogenic role of antigen-antibody complexes -- Introduction -- Host factors that influence development of immune complex disease -- Detection of soluble immune complexes -- Role of immune complexes in human disease -- Therapeutic approaches to immune complex disease -- Bibliography -- 24. Immune system modulators -- Introduction -- Immunosuppression -- Immunosuppressive drugs: Pharmacological and immunological aspects -- Adverse effects of prolonged immunosuppression -- Immunopotentiation -- Cancer immunotherapy