Platinum(IV)-Estramustine Multiaction Prodrugs Are Effective Antiproliferative Agents against Prostate Cancer Cells

Herein, we describe the synthesis, characterization, and biological properties of Pt(IV) derivatives of cisplatin with estramustine at the first axial position, which is known to disrupt the microtubule assembly and act as an androgen antagonist, and varying the second axial position using an innoce...

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Vydané v:	Journal of medicinal chemistry Ročník 63; číslo 22; s. 13861
Hlavní autori:	Karmakar, Subhendu, Kostrhunova, Hana, Ctvrtlikova, Tereza, Novohradsky, Vojtech, Gibson, Dan, Brabec, Viktor
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 25.11.2020
Predmet:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cisplatin - chemistry Drug Screening Assays, Antitumor Estramustine - chemistry Humans Male Prodrugs - chemistry Prodrugs - pharmacology Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Tumor Cells, Cultured
ISSN:	1520-4804, 1520-4804
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