Platinum(IV)-Estramustine Multiaction Prodrugs Are Effective Antiproliferative Agents against Prostate Cancer Cells

Herein, we describe the synthesis, characterization, and biological properties of Pt(IV) derivatives of cisplatin with estramustine at the first axial position, which is known to disrupt the microtubule assembly and act as an androgen antagonist, and varying the second axial position using an innoce...

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Veröffentlicht in:	Journal of medicinal chemistry Jg. 63; H. 22; S. 13861
Hauptverfasser:	Karmakar, Subhendu, Kostrhunova, Hana, Ctvrtlikova, Tereza, Novohradsky, Vojtech, Gibson, Dan, Brabec, Viktor
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 25.11.2020
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cisplatin - chemistry Drug Screening Assays, Antitumor Estramustine - chemistry Humans Male Prodrugs - chemistry Prodrugs - pharmacology Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Tumor Cells, Cultured
ISSN:	1520-4804, 1520-4804
Online-Zugang:	Weitere Angaben
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