A reproducible and high-throughput HPLC/MS method to separate sarcosine from α- and β-alanine and to quantify sarcosine in human serum and urine

While sarcosine was recently identified as a potential urine biomarker for prostate cancer, further studies have cast doubt on its utility to diagnose this condition. The inconsistent results may be due to the fact that alanine and sarcosine coelute on an HPLC reversed-phase column and the mass spec...

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Vydáno v:	Analytical chemistry (Washington) Ročník 83; číslo 14; s. 5735
Hlavní autoři:	Meyer, Tamra E, Fox, Stephen D, Issaq, Haleem J, Xu, Xia, Chu, Lisa W, Veenstra, Timothy D, Hsing, Ann W
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 15.07.2011
Témata:	Aged Alanine - isolation & purification beta-Alanine - isolation & purification Chromatography, High Pressure Liquid - methods Humans Male Mass Spectrometry - methods Middle Aged Reproducibility of Results Sarcosine - blood Sarcosine - isolation & purification Sarcosine - urine Sensitivity and Specificity
ISSN:	1520-6882, 1520-6882
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