Gold Nanocages:  Bioconjugation and Their Potential Use as Optical Imaging Contrast Agents

Gold nanocages of <40 nm in dimension have been synthesized using the galvanic replacement reaction between Ag nanocubes and HAuCl4 in an aqueous solution. By controlling the molar ratio between Ag and HAuCl4, the gold nanocages could be tuned to display surface plasmon resonance peaks around 800...

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Bibliographic Details
Published in:Nano letters Vol. 5; no. 3; pp. 473 - 477
Main Authors: Chen, Jingyi, Saeki, Fusayo, Wiley, Benjamin J., Cang, Hu, Cobb, Michael J., Li, Zhi-Yuan, Au, Leslie, Zhang, Hui, Kimmey, Michael B., Li, Xingde, Xia, Younan
Format: Journal Article
Language:English
Published: Washington, DC American Chemical Society 01.03.2005
Subjects:
Cell Line, Tumor
Chemical synthesis methods
Contrast Media
Cross-disciplinary physics: materials science; rheology
Crystallization - methods
Exact sciences and technology
Gold - chemistry
Humans
Immunoassay - methods
Materials science
Materials Testing
Methods of nanofabrication
Nanostructures - chemistry
Nanostructures - ultrastructure
Neoplasms - pathology
Particle Size
Phantoms, Imaging
Physics
Surface Plasmon Resonance - methods
Tomography, Optical Coherence - methods
Scanning electron microscopy
Gold
Inorganic compounds
Cage
Nanocage
Experimental study
Transmission electron microscopy
Near infrared spectrum
Transition elements
Tomography
Ultraviolet visible spectrum
Surface plasmon resonance
Nanostructured materials
ISSN:1530-6984, 1530-6992
Online Access:Get full text
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Summary:Gold nanocages of <40 nm in dimension have been synthesized using the galvanic replacement reaction between Ag nanocubes and HAuCl4 in an aqueous solution. By controlling the molar ratio between Ag and HAuCl4, the gold nanocages could be tuned to display surface plasmon resonance peaks around 800 nm, a wavelength commonly used in optical coherence tomography (OCT) imaging. OCT measurements on phantom samples indicate that these gold nanocages have a moderate scattering cross-section of ∼8.10 × 10-16 m2 but a very large absorption cross-section of ∼7.26 × 10-15 m2, suggesting their potential use as a new class of contrast agents for optical imaging. When bioconjugated with antibodies, the gold nanocages have also been demonstrated for specific targeting of breast cancer cells.
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ISSN:1530-6984
1530-6992
DOI:10.1021/nl047950t