HiBiT-SpyTag: A Minimal Tag for Covalent Protein Capture and Degrader Development

The ability to rapidly and selectively modulate cellular protein levels using small molecules is essential for studying complex biological systems. Degradation tags, such as dTAG, allow for selective protein removal with a specific degrader molecule, but their utility is limited by the large tag siz...

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Veröffentlicht in:	ACS chemical biology Jg. 18; H. 4; S. 933
Hauptverfasser:	Tsang, Tiffany, Huerta, Fidel, Liu, Yingpeng, Che, Jianwei, Metivier, Rebecca J, Ferrao, Silas, Donovan, Katherine A, Jones, Lyn H, Zerfas, Breanna L, Nowak, Radosław P
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 21.04.2023
Schlagworte:	Chromatography, Affinity - methods Endoribonucleases Molecular Probes - chemistry Molecular Probes - metabolism Nuclear Proteins Peptides - chemistry Protein Serine-Threonine Kinases Proteolysis Proteolysis Targeting Chimera - chemistry Proteolysis Targeting Chimera - metabolism Transcription Factors
ISSN:	1554-8937, 1554-8937
Online-Zugang:	Weitere Angaben
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