Extreme Basicity of Biguanide Drugs in Aqueous Solutions: Ion Transfer Voltammetry and DFT Calculations

Ion transfer voltammetry is used to estimate the acid dissociation constants Ka1 and Ka2 of the mono- and diprotonated forms of the biguanide drugs metformin (MF), phenformin (PF), and 1-phenylbiguanide (PB) in an aqueous solution. Measurements gave the pKa1 values for MFH(+), PFH(+), and PBH(+) cha...

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Vydané v:	The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory Ročník 120; číslo 37; s. 7344
Hlavní autori:	Langmaier, Jan, Pižl, Martin, Samec, Zdeněk, Záliš, Stanislav
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 22.09.2016
Predmet:	Biguanides - chemistry Hydrogen-Ion Concentration Metformin - chemistry Models, Molecular Phenformin - chemistry Quantum Theory Solutions - chemistry Water - chemistry
ISSN:	1520-5215, 1520-5215
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