Nested Russian Doll-Like Genetic Mobility Drives Rapid Dissemination of the Carbapenem Resistance Gene blaKPC

The recent widespread emergence of carbapenem resistance in Enterobacteriaceae is a major public health concern, as carbapenems are a therapy of last resort against this family of common bacterial pathogens. Resistance genes can mobilize via various mechanisms, including conjugation and transpositio...

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Vydáno v:	Antimicrobial agents and chemotherapy Ročník 60; číslo 6; s. 3767 - 3778
Hlavní autoři:	Sheppard, Anna E, Stoesser, Nicole, Wilson, Daniel J, Sebra, Robert, Kasarskis, Andrew, Anson, Luke W, Giess, Adam, Pankhurst, Louise J, Vaughan, Alison, Grim, Christopher J, Cox, Heather L, Yeh, Anthony J, Sifri, Costi D, Walker, A Sarah, Peto, Tim E, Crook, Derrick W, Mathers, Amy J
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.06.2016
Témata:	Anti-Bacterial Agents - pharmacology Bacterial Typing Techniques beta-Lactam Resistance - genetics beta-Lactamases - genetics beta-Lactamases - metabolism Carbapenems - pharmacology Conjugation, Genetic DNA Transposable Elements Enterobacteriaceae - classification Enterobacteriaceae - drug effects Enterobacteriaceae - genetics Enterobacteriaceae - isolation & purification Enterobacteriaceae Infections - drug therapy Enterobacteriaceae Infections - epidemiology Enterobacteriaceae Infections - microbiology Gene Expression Gene Transfer, Horizontal High-Throughput Nucleotide Sequencing Homologous Recombination Humans Phylogeny Plasmids - chemistry Plasmids - metabolism Public Health Surveillance Tertiary Care Centers Virginia - epidemiology
ISSN:	1098-6596
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