Nested Russian Doll-Like Genetic Mobility Drives Rapid Dissemination of the Carbapenem Resistance Gene blaKPC

The recent widespread emergence of carbapenem resistance in Enterobacteriaceae is a major public health concern, as carbapenems are a therapy of last resort against this family of common bacterial pathogens. Resistance genes can mobilize via various mechanisms, including conjugation and transpositio...

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Bibliographic Details
Published in:	Antimicrobial agents and chemotherapy Vol. 60; no. 6; pp. 3767 - 3778
Main Authors:	Sheppard, Anna E, Stoesser, Nicole, Wilson, Daniel J, Sebra, Robert, Kasarskis, Andrew, Anson, Luke W, Giess, Adam, Pankhurst, Louise J, Vaughan, Alison, Grim, Christopher J, Cox, Heather L, Yeh, Anthony J, Sifri, Costi D, Walker, A Sarah, Peto, Tim E, Crook, Derrick W, Mathers, Amy J
Format:	Journal Article
Language:	English
Published:	United States 01.06.2016
Subjects:	Anti-Bacterial Agents - pharmacology Bacterial Typing Techniques beta-Lactam Resistance - genetics beta-Lactamases - genetics beta-Lactamases - metabolism Carbapenems - pharmacology Conjugation, Genetic DNA Transposable Elements Enterobacteriaceae - classification Enterobacteriaceae - drug effects Enterobacteriaceae - genetics Enterobacteriaceae - isolation & purification Enterobacteriaceae Infections - drug therapy Enterobacteriaceae Infections - epidemiology Enterobacteriaceae Infections - microbiology Gene Expression Gene Transfer, Horizontal High-Throughput Nucleotide Sequencing Homologous Recombination Humans Phylogeny Plasmids - chemistry Plasmids - metabolism Public Health Surveillance Tertiary Care Centers Virginia - epidemiology
ISSN:	1098-6596
Online Access:	Get more information
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