A Magneto-Optical Nanoplatform for Multimodality Imaging of Tumors in Mice

Multimodality imaging involves the use of more imaging modes to image the same living subjects and is now generally preferred in clinics for cancer imaging. Here we present multimodalityMagnetic Particle Imaging (MPI), Magnetic Resonance Imaging (MRI), Photoacoustic, Fluorescentnanoparticles (term...

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Bibliographic Details
Published in:ACS nano Vol. 13; no. 7; pp. 7750 - 7758
Main Authors: Song, Guosheng, Zheng, Xianchuang, Wang, Youjuan, Xia, Xin, Chu, Steven, Rao, Jianghong
Format: Journal Article
Language:English
Published: United States American Chemical Society 23.07.2019
Subjects:
multimodality imaging
tumor imaging
iron oxide nanoparticles
semiconducting polymers
magnetic particle imaging
long blood circulation
ISSN:1936-0851, 1936-086X, 1936-086X
Online Access:Get full text
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Summary:Multimodality imaging involves the use of more imaging modes to image the same living subjects and is now generally preferred in clinics for cancer imaging. Here we present multimodalityMagnetic Particle Imaging (MPI), Magnetic Resonance Imaging (MRI), Photoacoustic, Fluorescentnanoparticles (termed MMPF NPs) for imaging tumor xenografts in living mice. MMPF NPs provide long-term (more than 2 months), dynamic, and accurate quantification, in vivo, of NPs and in real time by MPI. Moreover, MMPF NPs offer ultrasensitive MPI imaging of tumors (the tumor ROI increased by 30.6 times over that of preinjection). Moreover, the nanoparticle possessed a long-term blood circulation time (half-life at 49 h) and high tumor uptake (18% ID/g). MMPF NPs have been demonstrated for imaging breast and brain tumor xenografts in both subcutaneous and orthotopic models in mice via simultaneous MPI, MRI, fluorescence, and photoacoustic imaging with excellent tumor contrast to normal tissues.
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ISSN:1936-0851
1936-086X
1936-086X
DOI:10.1021/acsnano.9b01436