A Magneto-Optical Nanoplatform for Multimodality Imaging of Tumors in Mice
Multimodality imaging involves the use of more imaging modes to image the same living subjects and is now generally preferred in clinics for cancer imaging. Here we present multimodalityMagnetic Particle Imaging (MPI), Magnetic Resonance Imaging (MRI), Photoacoustic, Fluorescentnanoparticles (term...
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| Veröffentlicht in: | ACS nano Jg. 13; H. 7; S. 7750 - 7758 |
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| Format: | Journal Article |
| Sprache: | Englisch |
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American Chemical Society
23.07.2019
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| ISSN: | 1936-0851, 1936-086X, 1936-086X |
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| Abstract | Multimodality imaging involves the use of more imaging modes to image the same living subjects and is now generally preferred in clinics for cancer imaging. Here we present multimodalityMagnetic Particle Imaging (MPI), Magnetic Resonance Imaging (MRI), Photoacoustic, Fluorescentnanoparticles (termed MMPF NPs) for imaging tumor xenografts in living mice. MMPF NPs provide long-term (more than 2 months), dynamic, and accurate quantification, in vivo, of NPs and in real time by MPI. Moreover, MMPF NPs offer ultrasensitive MPI imaging of tumors (the tumor ROI increased by 30.6 times over that of preinjection). Moreover, the nanoparticle possessed a long-term blood circulation time (half-life at 49 h) and high tumor uptake (18% ID/g). MMPF NPs have been demonstrated for imaging breast and brain tumor xenografts in both subcutaneous and orthotopic models in mice via simultaneous MPI, MRI, fluorescence, and photoacoustic imaging with excellent tumor contrast to normal tissues. |
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| AbstractList | Multimodality imaging involves the use of more imaging modes to image the same living subjects and is now generally preferred in clinics for cancer imaging. Here we present multimodality-Magnetic Particle Imaging (MPI), Magnetic Resonance Imaging (MRI), Photoacoustic, Fluorescent-nanoparticles (termed MMPF NPs) for imaging tumor xenografts in living mice. MMPF NPs provide long-term (more than 2 months), dynamic, and accurate quantification, in vivo, of NPs and in real time by MPI. Moreover, MMPF NPs offer ultrasensitive MPI imaging of tumors (the tumor ROI increased by 30.6 times over that of preinjection). Moreover, the nanoparticle possessed a long-term blood circulation time (half-life at 49 h) and high tumor uptake (18% ID/g). MMPF NPs have been demonstrated for imaging breast and brain tumor xenografts in both subcutaneous and orthotopic models in mice via simultaneous MPI, MRI, fluorescence, and photoacoustic imaging with excellent tumor contrast to normal tissues.Multimodality imaging involves the use of more imaging modes to image the same living subjects and is now generally preferred in clinics for cancer imaging. Here we present multimodality-Magnetic Particle Imaging (MPI), Magnetic Resonance Imaging (MRI), Photoacoustic, Fluorescent-nanoparticles (termed MMPF NPs) for imaging tumor xenografts in living mice. MMPF NPs provide long-term (more than 2 months), dynamic, and accurate quantification, in vivo, of NPs and in real time by MPI. Moreover, MMPF NPs offer ultrasensitive MPI imaging of tumors (the tumor ROI increased by 30.6 times over that of preinjection). Moreover, the nanoparticle possessed a long-term blood circulation time (half-life at 49 h) and high tumor uptake (18% ID/g). MMPF NPs have been demonstrated for imaging breast and brain tumor xenografts in both subcutaneous and orthotopic models in mice via simultaneous MPI, MRI, fluorescence, and photoacoustic imaging with excellent tumor contrast to normal tissues. Multimodality imaging involves the use of more imaging modes to image the same living subjects and is now generally preferred in clinics for cancer imaging. Here we present multimodality-Magnetic Particle Imaging (MPI), Magnetic Resonance Imaging (MRI), Photoacoustic, Fluorescent-nanoparticles (termed MMPF NPs) for imaging tumor xenografts in living mice. MMPF NPs provide long-term (more than 2 months), dynamic, and accurate quantification, , of NPs and in real time by MPI. Moreover, MMPF NPs offer ultrasensitive MPI imaging of tumors (the tumor ROI increased by 30.6 times over that of preinjection). Moreover, the nanoparticle possessed a long-term blood circulation time (half-life at 49 h) and high tumor uptake (18% ID/g). MMPF NPs have been demonstrated for imaging breast and brain tumor xenografts in both subcutaneous and orthotopic models in mice via simultaneous MPI, MRI, fluorescence, and photoacoustic imaging with excellent tumor contrast to normal tissues. Multimodality imaging involves the use of more imaging modes to image the same living subjects and is now generally preferred in clinics for cancer imaging. Here we present multimodalityMagnetic Particle Imaging (MPI), Magnetic Resonance Imaging (MRI), Photoacoustic, Fluorescentnanoparticles (termed MMPF NPs) for imaging tumor xenografts in living mice. MMPF NPs provide long-term (more than 2 months), dynamic, and accurate quantification, in vivo, of NPs and in real time by MPI. Moreover, MMPF NPs offer ultrasensitive MPI imaging of tumors (the tumor ROI increased by 30.6 times over that of preinjection). Moreover, the nanoparticle possessed a long-term blood circulation time (half-life at 49 h) and high tumor uptake (18% ID/g). MMPF NPs have been demonstrated for imaging breast and brain tumor xenografts in both subcutaneous and orthotopic models in mice via simultaneous MPI, MRI, fluorescence, and photoacoustic imaging with excellent tumor contrast to normal tissues. |
| Author | Wang, Youjuan Chu, Steven Zheng, Xianchuang Rao, Jianghong Song, Guosheng Xia, Xin |
| AuthorAffiliation | State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering Departments of Physics and Molecular & Cellular Physiology Molecular Imaging Program at Stanford, Department of Radiology |
| AuthorAffiliation_xml | – name: Departments of Physics and Molecular & Cellular Physiology – name: Molecular Imaging Program at Stanford, Department of Radiology – name: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering |
| Author_xml | – sequence: 1 givenname: Guosheng orcidid: 0000-0001-5628-6245 surname: Song fullname: Song, Guosheng organization: Molecular Imaging Program at Stanford, Department of Radiology – sequence: 2 givenname: Xianchuang surname: Zheng fullname: Zheng, Xianchuang organization: Molecular Imaging Program at Stanford, Department of Radiology – sequence: 3 givenname: Youjuan surname: Wang fullname: Wang, Youjuan organization: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering – sequence: 4 givenname: Xin surname: Xia fullname: Xia, Xin organization: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering – sequence: 5 givenname: Steven surname: Chu fullname: Chu, Steven organization: Departments of Physics and Molecular & Cellular Physiology – sequence: 6 givenname: Jianghong orcidid: 0000-0002-5143-9529 surname: Rao fullname: Rao, Jianghong email: jrao@stanford.edu organization: Molecular Imaging Program at Stanford, Department of Radiology |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31244043$$D View this record in MEDLINE/PubMed |
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| Keywords | multimodality imaging tumor imaging iron oxide nanoparticles semiconducting polymers magnetic particle imaging long blood circulation |
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