Process-Ready Nickel-Catalyzed Suzuki-Miyaura Coupling Enabled by tri -ProPhos

The synthesis of active pharmaceutical ingredients (APIs) containing heteroaromatic motifs often relies on palladium-catalyzed Suzuki-Miyaura coupling (Pd-SMC), a transformation that can account for a significant portion of the production costs for small-molecule drugs. Nickel-catalyzed SMC offers a...

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Bibliographic Details

Published in:	ACS catalysis Vol. 15; no. 22; p. 19302
Main Authors:	Yang, Jin, Zhao, Hengyuan, Schultz, Johnathan E, Wisniewski, Steven R, Simmons, Eric M, Diao, Tianning
Format:	Journal Article
Language:	English
Published:	United States 21.11.2025
Subjects:	green-solvent nickel Suzuki–Miyaura ProPhos heterocycles pharmaceutical process synthesis
ISSN:	2155-5435, 2155-5435
Online Access:	Get more information
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