A multiple hydrogen-bond scaffold based on dipyrimidin-2-ylamine

[GRAPHICS] A multiple hydrogen-bond array based on dipyrimidin-2-ylamine is presented, which is easily accessible. The influence of a preorganizing intramolecular hydrogen bond, tautomeric equilibria, and steric effects on the association behavior were investigated. X-ray diffraction shows that the...

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Vydáno v:Organic letters Ročník 3; číslo 24; s. 3887 - 3889
Hlavní autoři: Sontjens, SHM, Meijer, JT, Kooijman, H, Spek, AL, van Genderen, MHP, Sijbesma, RP, Meijer, EW
Médium: Journal Article
Jazyk:angličtina
Vydáno: WASHINGTON Amer Chemical Soc 29.11.2001
Témata:
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ISSN:1523-7060, 1523-7052
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Shrnutí:[GRAPHICS] A multiple hydrogen-bond array based on dipyrimidin-2-ylamine is presented, which is easily accessible. The influence of a preorganizing intramolecular hydrogen bond, tautomeric equilibria, and steric effects on the association behavior were investigated. X-ray diffraction shows that the molecules feature an ADA (acceptor-donor-acceptor) array of hydrogen-bonding sites in the solid state. The array persists in solution, and H-1 NMR titrations show that molecules with sterically nondemanding DAD arrays are selectively bound.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol016750a