BoostDILI: Extreme Gradient Boost-Powered Drug-Induced Liver Injury Prediction and Structural Alerts Generation

Over the past 60 years, drug-induced liver injury (DILI) has played a key role in the withdrawal of marketed drugs due to safety concerns. Early prediction of DILI is crucial for developing safer pharmaceuticals, yet current and testing methods are complex and cumbersome. In this study, we developed...

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Vydáno v:	Chemical research in toxicology Ročník 38; číslo 5; s. 865
Hlavní autoři:	Chutia, Hillul, Borah, Gori Sankar, Mahanta, Hridoy Jyoti, Nagamani, Selvaraman
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 19.05.2025
Témata:	Boosting Machine Learning Algorithms Chemical and Drug Induced Liver Injury Humans Machine Learning Pharmaceutical Preparations - chemistry United States Food and Drug Administration
ISSN:	1520-5010, 1520-5010
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