Nickel-Catalyzed Cascade Reaction of 2-Vinylanilines with gem-Dichloroalkenes

An efficient nickel-catalyzed cascade reaction of 2-vinylanilines with gem-dichloroalkenes has been developed to deliver diversely substituted quinolines in good to high yields. This protocol enables effective access to quinolines bearing various functional groups in the cascade process from readily...

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Vydané v:Organic letters Ročník 24; číslo 27; s. 4855 - 4859
Hlavní autori: Lin, Jin, Wu, Chaoyi, Tian, Xu
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: WASHINGTON Amer Chemical Soc 15.07.2022
Predmet:
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
QUINOLINE
TANDEM
ANTICANCER
COUPLING REACTIONS
ONE-POT
EFFICIENT
DERIVATIVES
INDOLES
ISSN:1523-7060, 1523-7052, 1523-7052
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Popis
Shrnutí:An efficient nickel-catalyzed cascade reaction of 2-vinylanilines with gem-dichloroalkenes has been developed to deliver diversely substituted quinolines in good to high yields. This protocol enables effective access to quinolines bearing various functional groups in the cascade process from readily available feedstock chemicals. Mechanistic studies suggest that two plausible pathways are involved in the IPr-nickel catalytic system.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/acs.orglett.2c01492