Nickel-Catalyzed Cascade Reaction of 2-Vinylanilines with gem-Dichloroalkenes
An efficient nickel-catalyzed cascade reaction of 2-vinylanilines with gem-dichloroalkenes has been developed to deliver diversely substituted quinolines in good to high yields. This protocol enables effective access to quinolines bearing various functional groups in the cascade process from readily...
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| Published in: | Organic letters Vol. 24; no. 27; pp. 4855 - 4859 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
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Amer Chemical Soc
15.07.2022
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| ISSN: | 1523-7060, 1523-7052, 1523-7052 |
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| Abstract | An efficient nickel-catalyzed cascade reaction of 2-vinylanilines with gem-dichloroalkenes has been developed to deliver diversely substituted quinolines in good to high yields. This protocol enables effective access to quinolines bearing various functional groups in the cascade process from readily available feedstock chemicals. Mechanistic studies suggest that two plausible pathways are involved in the IPr-nickel catalytic system. |
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| AbstractList | An efficient nickel-catalyzed cascade reaction of 2-vinylanilines with gem-dichloroalkenes has been developed to deliver diversely substituted quinolines in good to high yields. This protocol enables effective access to quinolines bearing various functional groups in the cascade process from readily available feedstock chemicals. Mechanistic studies suggest that two plausible pathways are involved in the IPr-nickel catalytic system. An efficient nickel-catalyzed cascade reaction of 2-vinylanilines with gem-dichloroalkenes has been developed to deliver diversely substituted quinolines in good to high yields. This protocol enables effective access to quinolines bearing various functional groups in the cascade process from readily available feedstock chemicals. Mechanistic studies suggest that two plausible pathways are involved in the IPr-nickel catalytic system.An efficient nickel-catalyzed cascade reaction of 2-vinylanilines with gem-dichloroalkenes has been developed to deliver diversely substituted quinolines in good to high yields. This protocol enables effective access to quinolines bearing various functional groups in the cascade process from readily available feedstock chemicals. Mechanistic studies suggest that two plausible pathways are involved in the IPr-nickel catalytic system. |
| Author | Lin, Jin Wu, Chaoyi Tian, Xu |
| Author_xml | – sequence: 1 givenname: Jin surname: Lin fullname: Lin, Jin organization: Guangzhou Med Univ, Guangzhou Municipal & Guangdong Prov Key Lab Mol T, NMPA, Guangzhou 511436, Guangdong, Peoples R China – sequence: 2 givenname: Chaoyi surname: Wu fullname: Wu, Chaoyi organization: Guangzhou Med Univ, Guangzhou Municipal & Guangdong Prov Key Lab Mol T, NMPA, Guangzhou 511436, Guangdong, Peoples R China – sequence: 3 givenname: Xu orcidid: 0000-0002-4508-8347 surname: Tian fullname: Tian, Xu email: xtian@gzhmu.edu.cn organization: Guangzhou Med Univ, Guangzhou Municipal & Guangdong Prov Key Lab Mol T, NMPA, Guangzhou 511436, Guangdong, Peoples R China |
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| CitedBy_id | crossref_primary_10_1021_acs_orglett_5c02308 crossref_primary_10_1016_j_tetlet_2023_154700 crossref_primary_10_1002_jhet_4838 crossref_primary_10_1016_j_tet_2024_134089 crossref_primary_10_1039_D2CC03007A crossref_primary_10_1080_08827508_2023_2214668 |
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| Keywords | QUINOLINE TANDEM ANTICANCER COUPLING REACTIONS ONE-POT EFFICIENT DERIVATIVES INDOLES |
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| Title | Nickel-Catalyzed Cascade Reaction of 2-Vinylanilines with gem-Dichloroalkenes |
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