Nickel-Catalyzed Cascade Reaction of 2-Vinylanilines with gem-Dichloroalkenes

An efficient nickel-catalyzed cascade reaction of 2-vinylanilines with gem-dichloroalkenes has been developed to deliver diversely substituted quinolines in good to high yields. This protocol enables effective access to quinolines bearing various functional groups in the cascade process from readily...

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Bibliographic Details
Published in:Organic letters Vol. 24; no. 27; pp. 4855 - 4859
Main Authors: Lin, Jin, Wu, Chaoyi, Tian, Xu
Format: Journal Article
Language:English
Published: WASHINGTON Amer Chemical Soc 15.07.2022
Subjects:
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
QUINOLINE
TANDEM
ANTICANCER
COUPLING REACTIONS
ONE-POT
EFFICIENT
DERIVATIVES
INDOLES
ISSN:1523-7060, 1523-7052, 1523-7052
Online Access:Get more information
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Summary:An efficient nickel-catalyzed cascade reaction of 2-vinylanilines with gem-dichloroalkenes has been developed to deliver diversely substituted quinolines in good to high yields. This protocol enables effective access to quinolines bearing various functional groups in the cascade process from readily available feedstock chemicals. Mechanistic studies suggest that two plausible pathways are involved in the IPr-nickel catalytic system.
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ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/acs.orglett.2c01492