Synthesis of Best-Seller Drugs

This book is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the m...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Vardanyan, R. S. (Ruben S.), Hruby, Victor J.
Format: E-Book Buch
Sprache:Englisch
Veröffentlicht: Amsterdam Elsevier 2016
Academic Press
Elsevier Science & Technology
Ausgabe:1
Schlagworte:
Drugs
Drugs > Synthesis
Pharmaceuticals
Pharmaceuticals, Cosmetics & Toiletries
ISBN:9780124114920, 012411492X
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Inhaltsangabe:
  • Title Page Preface Table of Contents 1. General Anesthetics 2. Local Anesthetics 3. Analgesics 4. Soporific Agents (Hypnotics and Sedative Drugs) 5. Anxiolytics (Tranquilizers) 6. Antipsychotics 7. Antidepressants 8. Central Nervous System Stimulants 9. Antiepileptic Drugs 10. Antiparkinsonian Drugs 11. Adrenergic (Sympathomimetic) Drugs 12. Adrenoblockers 13. Cholinomimetics 14. Anticholinergic Drugs 15. Centrally Acting Skeletal Muscle Relaxants 16. Antihistamine Drugs 17. Cardiotonic Inotropic Drugs 18. Antiarrhythmic Drugs 19. Antianginal Drugs 20. Hypolipidemic and Antihyperlipidemic Drugs 21. Diuretics 22. Antihypertensive Drugs 23. Drugs for Treating Respiratory System Diseases 24. Antithrombotic Drugs (Anticoagulants, Antiplatelets, and Thrombolytics) 25. Thyroid and Antithyroid Drugs 26. Hyperglycemic and Hypoglycemic Drugs 27. Steroid Hormones 28. Antineoplastic Agents 29. Immunopharmacological Drugs 30. Antibiotics 31. Antibacterial Drugs 32. Antimicobacterial Drugs 33. Antifungal Drugs 34. Antiviral Drugs 35. Drugs for Treating Protozoan Infections 36. Anthelmintics 37. Proton Pump Inhibitors 38. Drugs for Treatment of Erectile Dysfunction Drugs Index Subject Index
  • 7.3 SELECTIVE SEROTONIN REUPTAKE INHIBITORS -- Fluoxetine-Prozac -- Paroxetine-Paxil -- Sertraline-Zoloft -- Fluvoxamine-Luvox -- Citalopram-Celexa and Escitalopram-Lexapro -- Vilazodone-Viibryd -- 7.4 SELECTIVE NOREPINEPHRINE (NORADRENALINE) REUPTAKE INHIBITORS -- Atomoxetine-Strattera -- 7.5 DUAL UPTAKE INHIBITORS (SSRI/SNRI) -- Duloxetine-Cymbalta -- Venlafaxine-Effexor -- 7.6 DUAL UPTAKE INHIBITORS (SNRI/SDARI) -- 7.7 TRIPLE UPTAKE INHIBITORS (SSRI/SNRI/SDARI) -- REFERENCES -- 8 - Central Nervous System Stimulants -- Lisdexamfetamine-Vyvanse -- Methylphenidate-Ritalin (Concerta, an Extended-Release Form of Ritalin) -- Dexmethylphenidate-Focalin (D-Threo-Methylphenidate) -- Armodafinil-Nuvigil -- REFERENCES -- 9 - Antiepileptic Drugs -- Pregabalin-Lyrica -- Lamotrigine-Lamictal -- Levetiracetam-Keppra -- Topiramate-Topamax -- REFERENCES -- 10 - Antiparkinsonian Drugs -- 10.1 LEVODOPA (LEVODOPA-CARBIDOPA) -- 10.2 DOPAMINE AGONISTS -- 10.3 ANTICHOLINERGICS -- 10.4 MAO INHIBITORS -- 10.5 CATECHOL-O-METHYLTRANSFERASE INHIBITORS -- 10.6 AMANTADINE -- 10.7 NEW DRUGS IN DEVELOPMENT FOR PARKINSON DISEASE -- REFERENCES -- 11 - Adrenergic (Sympathomimetic) Drugs -- 11.1 α1-RECEPTOR ACTIVATING DRUGS -- 11.2 α2-RECEPTOR ACTIVATING DRUGS -- 11.3 β1-RECEPTOR ACTIVATING DRUGS -- 11.4 β2-RECEPTOR ACTIVATING DRUGS -- 11.5 DOPAMINE-RECEPTOR ACTIVATING DRUGS -- 11.6 MULTIPLE ADRENORECEPTOR ACTIVATION -- 11.7 DOPAMINE-RECEPTOR AGONIST BESTSELL -- Guanfacine-Intuniv -- Albuterol-Salbutamol -- 12 - Adrenoblockers -- 12.1 α ADRENOBLOCKERS -- Nonselective α Adrenoblockers -- Selective α1 Adrenoblockers -- Selective α2 Adrenoblockers -- Alfuzosin-Uroxatral -- Tamsulosin-Flomax -- 12.2 Β ADRENOBLOCKERS -- Nonselective β Adrenoblockers (First-Generation β Blockers) -- Cardioselective β1 Blockers (Second-Generation β Blockers)
  • Direct Renin Inhibitors
  • Front Cover -- Synthesis of Best-Seller Drugs -- Copyright -- Dedication -- Contents -- Preface -- 1 - General Anesthetics -- 1.1 NONINHALATION COMPONENTS FOR GENERAL ANESTHESIA -- Tranquilizers -- Central Nervous System Depressants (Barbiturates and Hypnotic Agents) -- Opioid Analgesics -- Ketamine -- Muscle Relaxants -- Reversible Acetylcholinesterase Inhibitors -- 1.2 INHALATION ANESTHETICS -- REFERENCES -- 2 - Local Anesthetics -- 2.1 AMINOESTER ANESTHETICS -- 2.2 AMINOAMIDE ANESTHETICS -- REFERENCES -- 3 - Analgesics -- 3.1 NONSTEROIDAL ANTIINFLAMMATORY DRUGS -- p-Aminophenol Derivatives -- Salicylic Acid Derivatives -- Asacol-Mesalazine -- Anthranilic Acid Derivatives -- Arylpropionic Acid Derivatives -- Arylacetic Acid Derivatives -- Indolyl-/Indoleacetic Acid Derivatives -- Oxicames -- Pyrazolones -- Selective COX-2 Inhibitors -- Celecoxib-Celebrex -- 3.2 OPIOID ANALGESICS -- 4,5-Epoxyorphinan Opium Alkaloids -- Morphine-Kadian-MS Contin -- Semisynthetic 4,5-Epoxyorphinan Derivatives (Agonists) -- Hydrocodone-Tussionex -- Oxycodone-OxyContin -- Oxymorphone-Opana -- Buprenorphine-Suboxone -- Semisynthetic 4,5-Epoxymorphinan Derivatives (Antagonists) -- Morphinans -- Decahydroisoquinolines -- Benzomorphans -- 4-Phenylpiperidines -- 4-Anylinopiperidines -- Fentanyl-Fentora -- δ-Opioid Ligands -- κ-Opioid Ligands -- ORL-1-Opioid Ligands -- 3.3 ADJUNCTIVE AGENTS IN THE MANAGEMENT OF PAIN, OR "NONANALGESIC" PAIN KILLERS -- Antidepressants as Analgesics -- Miscellaneous Antidepressants -- Serotonin Norepinephrine Reuptake Inhibitors Combination with μ-Opioid Receptor Agonist (Tapentadol) -- Gabapentinoids (Calcium Channel α2δ Ligands) -- Pregabalin-Lyrica -- Calcium Channel Blockers -- Sodium Channel Blockers -- Potassium Channel Modulators -- Glutamate Receptor Modulators -- N-Methyl-d-Aspartate Antagonists
  • α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Antagonists -- Kainate Receptor Antagonists -- TRPV1 Antagonists (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 Antagonists) -- α2-Adrenergic Agonists -- Modulators of Nicotinic Acetylcholine Receptors -- Neurokinin-1 Antagonists -- Cannabinoid Receptor Modulators -- Glial Inhibitors -- Cholecystokinin Antagonists -- Triptans -- Eletriptan-Relpax -- Rizatriptan-Maxalt -- REFERENCES -- 4 - Soporific Agents (Hypnotics and Sedative Drugs) -- 4.1 BARBITURATES -- 4.2 HISTAMINE H1 RECEPTOR ANTAGONISTS -- 4.3 BENZODIAZEPINES -- 4.4 Z-DRUGS -- Zolpidem-Ambien -- Eszopiclone-Lunesta -- 4.5 NEW GABA RECEPTOR AGONISTS -- 4.6 MELATONERGIC (MT1/MT2) AGONISTS -- 4.7 5-HT ANTAGONISTS AND ANTAGONISTS/INVERSE AGONISTS -- 4.8 NK1-RECEPTOR ANTAGONISTS -- 4.9 OREXIN RECEPTOR (OX1/OX2) ANTAGONISTS -- 4.10 SODIUM OXYBATE -- REFERENCES -- 5 - Anxiolytics (Tranquilizers) -- 5.1 BENZODIAZEPINES -- 5.2 ANXIOLYTIC DRUGS ACTING ON SEROTONIN RECEPTORS -- 5.3 ANXIOLYTIC DRUGS ACTING ON ADRENORECEPTORS -- 5.4 ANXIOLYTIC DRUGS ACTING ON GLUTAMATE RECEPTORS -- 5.5 ANXIOLYTIC COMPOUNDS ACTING ON OTHER RECEPTORS -- REFERENCES -- 6 - Antipsychotics -- 6.1 FIRST-GENERATION ANTIPSYCHOTICS -- Phenothiazines -- Thioxanthenes -- Butyrophenones -- Diphenylbutylpiperidines -- 6.2 SECOND-GENERATION ANTIPSYCHOTICS -- Dibenzodiazepines, Dibenzoxazepines, Dibenzothiazepines, and Benzothienodiazepines -- Quetiapine-Seroquel -- Olanzapine-Zyprexa -- Piperidinyl Isoxazoles, Piperazinyl Benzoisothiazoles, Piperidinylindoles -- Risperidone-Risperdal -- Sertindole-Serdolect -- Ziprasidone-Geodon -- Benzamides Sulpiride, Amisulpride -- 6.3 THIRD-GENERATION ANTIPSYCHOTICS -- Aripiprazole-Abilify -- REFERENCES -- 7 - Antidepressants -- 7.1 TRICYCLIC ANTIDEPRESSANTS -- 7.2 MONOAMINE OXIDASE INHIBITORS
  • β Blockers with Vasodilator Action (Third-Generation β Blockers) -- β2 Adrenoblockers -- β3 Adrenoblockers -- Carvedilol-Coreg -- Nebivolol-Bystolic -- REFERENCES -- 13 - Cholinomimetics -- 13.1 DIRECT-ACTING CHOLINOMIMETICS -- Mixed AChR Agonists -- Nicotinic AChR Agonists -- Muscarinic AChR Agonists -- 13.2 CHOLINESTERASE INHIBITORS (INDIRECT-ACTING CHOLINOMIMETICS) -- Donepezil-Aricept -- REFERENCES -- 14 - Anticholinergic Drugs -- 14.1 ANTINICOTINIC AGENTS (NEUROMUSCULAR BLOCKING DRUGS) -- 14.2 GANGLIONIC BLOCKERS -- 14.3 ANTIMUSCARINIC AGENTS -- Tiotropium Bromide-Spiriva -- Darifenacin-Enablex -- Solifenacin-VESIcare -- Tolterodine-Detrol -- REFERENCES -- 15 - Centrally Acting Skeletal Muscle Relaxants -- Metaxalone-Skelaxin -- REFERENCES -- 16 - Antihistamine Drugs -- 16.1 H1 ANTIHISTAMINES -- Olopatadine-Patanol -- Levocetirizine-Xyzal -- 16.2 H2 ANTIHISTAMINES -- 16.3 H3 ANTIHISTAMINES -- 16.4 H4 ANTIHISTAMINES -- REFERENCES -- 17 - Cardiotonic Inotropic Drugs -- 17.1 CLASS I CARDIOTONIC INOTROPIC AGENTS (DRUGS THAT INCREASE THE CYCLIC ADENOSINE MONOPHOSPHATE LEVEL) -- Drugs That Increase Cyclic Adenosine Monophosphate Level By β-Receptor Stimulation -- Drugs That Increase Cyclic Adenosine Monophosphate Level By Stimulating Adenylyl Cyclase -- Phosphodiesterase Inhibitors -- 17.2 CLASS II CARDIOTONIC INOTROPIC AGENTS (DRUGS THAT REGULATE ION CHANNELS OR PUMPS IN THE MYOCARDIAL CELL MEMBRANE) -- 17.3 CLASS III CARDIOTONIC INOTROPIC AGENTS (DRUGS THAT MODULATE INTRACELLULAR CALCIUM REGULATION) -- 17.4 CLASS IV DRUGS THAT MODULATE INTRACELLULAR CALCIUM REGULATION AGENTS (DRUGS THAT AUGMENT CONTRACTILITY THROUGH VARIOUS MECH... -- REFERENCES -- 18 - Antiarrhythmic Drugs -- 18.1 CLASS I -- Class Ia (Sodium Channel Blockers with Intermediate Association/Dissociation Kinetics and Action Potential Duration)
  • Class Ib (Sodium Channel Blockers with Rapid Association/Dissociation Kinetics) -- Class Ic (Sodium Channel Blockers with Slow Association/Dissociation Kinetics) -- 18.2 CLASS II -- 18.3 CLASS III -- 18.4 CLASS IV -- 18.5 CLASS V -- REFERENCES -- 19 - Antianginal Drugs -- 19.1 NITRATES -- 19.2 CALCIUM-CHANNEL BLOCKERS -- 19.3 Β-ADRENERGIC BLOCKERS -- 19.4 NOVEL ANTIANGINAL DRUGS -- Ranolazine-Ranexa -- REFERENCES -- 20 - Hypolipidemic and Antihyperlipidemic Drugs -- 20.1 STATINS -- Atorvastatin-Lipitor -- Rosuvastatin-Crestor -- 20.2 FIBRATES -- Fenofibrate-Tricor -- 20.3 BILE ACID SEQUESTRANTS -- Colesevelam-Welchol -- 20.4 EZETIMIBE-VYTORIN -- 20.5 NIACIN -- 20.6 OMEGA-3 FATTY ACIDS (FISH OILS) -- 20.7 NEW AGENTS FOR THE PHARMACOTHERAPY OF DYSLIPIDEMIA -- Microsomal Triglyceride Transfer Protein Inhibitors -- Squalene Synthase Inhibitors -- Preprotein Convertase Subtilisin Kexin-9 Inhibitors -- Antisense Oligonucleotide Therapies -- Cholesterol Ester Transfer Protein Inhibitors -- Peroxisomal Proliferator Activating Receptor-α and -γ Agonists -- REFERENCES -- 21 - Diuretics -- 21.1 CARBONIC ANHYDRASE INHIBITORS -- 21.2 LOOP DIURETICS (HIGH-CEILING DIURETICS) -- 21.3 DIURETICS ACTING AT THE DISTAL CONVOLUTED TUBULE -- Thiazides and Thiazide-Like Diuretics -- Thiazides -- Thiazide-Like Diuretics -- 21.4 DIURETICS ACTING AT THE COLLECTING DUCT SYSTEM -- Epithelial Sodium Channel Blockers -- Aldosterone Antagonists -- Vasopressin Antagonists -- 21.5 OSMOTIC DIURETICS -- 21.6 NOVEL DIURETIC TARGETS -- REFERENCES -- 22 - Antihypertensive Drugs -- 22.1 DIURETICS -- 22.2 Β BLOCKERS -- 22.3 CALCIUM-CHANNEL BLOCKERS -- 22.4 RENIN-ANGIOTENSIN SYSTEM BLOCKERS -- Angiotensin-Converting Enzyme Blockers -- Angiotensin II Receptor Blockers -- Losartan-Cozaar -- Olmesartan-Benicar -- Valsartan-Diovan -- Irbesartan-Avapro -- Telmisartan-Micardis