Synthesis of Best-Seller Drugs
This book is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the m...
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| Format: | eBook Book |
| Language: | English |
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Amsterdam
Elsevier
2016
Academic Press Elsevier Science & Technology |
| Edition: | 1 |
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| ISBN: | 9780124114920, 012411492X |
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| Abstract | This book is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. |
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| AbstractList | Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs.Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type.Each chapter reviews the main drugs in each of nearly. Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areasReviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation This book is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. |
| Author | Vardanyan Ruben Hruby Victor |
| Author_xml | – sequence: 1 fullname: Vardanyan, R. S. (Ruben S.) – sequence: 2 fullname: Hruby, Victor J. |
| BackLink | https://cir.nii.ac.jp/crid/1130000793942796160$$DView record in CiNii |
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| Copyright | 2016 |
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| DOI | 10.1016/C2012-0-07004-4 |
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| Discipline | Pharmacy, Therapeutics, & Pharmacology Medicine |
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| Notes | Includes bibliographical references and index |
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| PublicationPlace | Amsterdam |
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| Snippet | This book is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book... Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs.Designed for... Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for... |
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| SubjectTerms | Drugs Drugs -- Synthesis Pharmaceuticals Pharmaceuticals, Cosmetics & Toiletries |
| TableOfContents | Title Page
Preface
Table of Contents
1. General Anesthetics
2. Local Anesthetics
3. Analgesics
4. Soporific Agents (Hypnotics and Sedative Drugs)
5. Anxiolytics (Tranquilizers)
6. Antipsychotics
7. Antidepressants
8. Central Nervous System Stimulants
9. Antiepileptic Drugs
10. Antiparkinsonian Drugs
11. Adrenergic (Sympathomimetic) Drugs
12. Adrenoblockers
13. Cholinomimetics
14. Anticholinergic Drugs
15. Centrally Acting Skeletal Muscle Relaxants
16. Antihistamine Drugs
17. Cardiotonic Inotropic Drugs
18. Antiarrhythmic Drugs
19. Antianginal Drugs
20. Hypolipidemic and Antihyperlipidemic Drugs
21. Diuretics
22. Antihypertensive Drugs
23. Drugs for Treating Respiratory System Diseases
24. Antithrombotic Drugs (Anticoagulants, Antiplatelets, and Thrombolytics)
25. Thyroid and Antithyroid Drugs
26. Hyperglycemic and Hypoglycemic Drugs
27. Steroid Hormones
28. Antineoplastic Agents
29. Immunopharmacological Drugs
30. Antibiotics
31. Antibacterial Drugs
32. Antimicobacterial Drugs
33. Antifungal Drugs
34. Antiviral Drugs
35. Drugs for Treating Protozoan Infections
36. Anthelmintics
37. Proton Pump Inhibitors
38. Drugs for Treatment of Erectile Dysfunction
Drugs Index
Subject Index 7.3 SELECTIVE SEROTONIN REUPTAKE INHIBITORS -- Fluoxetine-Prozac -- Paroxetine-Paxil -- Sertraline-Zoloft -- Fluvoxamine-Luvox -- Citalopram-Celexa and Escitalopram-Lexapro -- Vilazodone-Viibryd -- 7.4 SELECTIVE NOREPINEPHRINE (NORADRENALINE) REUPTAKE INHIBITORS -- Atomoxetine-Strattera -- 7.5 DUAL UPTAKE INHIBITORS (SSRI/SNRI) -- Duloxetine-Cymbalta -- Venlafaxine-Effexor -- 7.6 DUAL UPTAKE INHIBITORS (SNRI/SDARI) -- 7.7 TRIPLE UPTAKE INHIBITORS (SSRI/SNRI/SDARI) -- REFERENCES -- 8 - Central Nervous System Stimulants -- Lisdexamfetamine-Vyvanse -- Methylphenidate-Ritalin (Concerta, an Extended-Release Form of Ritalin) -- Dexmethylphenidate-Focalin (D-Threo-Methylphenidate) -- Armodafinil-Nuvigil -- REFERENCES -- 9 - Antiepileptic Drugs -- Pregabalin-Lyrica -- Lamotrigine-Lamictal -- Levetiracetam-Keppra -- Topiramate-Topamax -- REFERENCES -- 10 - Antiparkinsonian Drugs -- 10.1 LEVODOPA (LEVODOPA-CARBIDOPA) -- 10.2 DOPAMINE AGONISTS -- 10.3 ANTICHOLINERGICS -- 10.4 MAO INHIBITORS -- 10.5 CATECHOL-O-METHYLTRANSFERASE INHIBITORS -- 10.6 AMANTADINE -- 10.7 NEW DRUGS IN DEVELOPMENT FOR PARKINSON DISEASE -- REFERENCES -- 11 - Adrenergic (Sympathomimetic) Drugs -- 11.1 α1-RECEPTOR ACTIVATING DRUGS -- 11.2 α2-RECEPTOR ACTIVATING DRUGS -- 11.3 β1-RECEPTOR ACTIVATING DRUGS -- 11.4 β2-RECEPTOR ACTIVATING DRUGS -- 11.5 DOPAMINE-RECEPTOR ACTIVATING DRUGS -- 11.6 MULTIPLE ADRENORECEPTOR ACTIVATION -- 11.7 DOPAMINE-RECEPTOR AGONIST BESTSELL -- Guanfacine-Intuniv -- Albuterol-Salbutamol -- 12 - Adrenoblockers -- 12.1 α ADRENOBLOCKERS -- Nonselective α Adrenoblockers -- Selective α1 Adrenoblockers -- Selective α2 Adrenoblockers -- Alfuzosin-Uroxatral -- Tamsulosin-Flomax -- 12.2 Β ADRENOBLOCKERS -- Nonselective β Adrenoblockers (First-Generation β Blockers) -- Cardioselective β1 Blockers (Second-Generation β Blockers) Direct Renin Inhibitors Front Cover -- Synthesis of Best-Seller Drugs -- Copyright -- Dedication -- Contents -- Preface -- 1 - General Anesthetics -- 1.1 NONINHALATION COMPONENTS FOR GENERAL ANESTHESIA -- Tranquilizers -- Central Nervous System Depressants (Barbiturates and Hypnotic Agents) -- Opioid Analgesics -- Ketamine -- Muscle Relaxants -- Reversible Acetylcholinesterase Inhibitors -- 1.2 INHALATION ANESTHETICS -- REFERENCES -- 2 - Local Anesthetics -- 2.1 AMINOESTER ANESTHETICS -- 2.2 AMINOAMIDE ANESTHETICS -- REFERENCES -- 3 - Analgesics -- 3.1 NONSTEROIDAL ANTIINFLAMMATORY DRUGS -- p-Aminophenol Derivatives -- Salicylic Acid Derivatives -- Asacol-Mesalazine -- Anthranilic Acid Derivatives -- Arylpropionic Acid Derivatives -- Arylacetic Acid Derivatives -- Indolyl-/Indoleacetic Acid Derivatives -- Oxicames -- Pyrazolones -- Selective COX-2 Inhibitors -- Celecoxib-Celebrex -- 3.2 OPIOID ANALGESICS -- 4,5-Epoxyorphinan Opium Alkaloids -- Morphine-Kadian-MS Contin -- Semisynthetic 4,5-Epoxyorphinan Derivatives (Agonists) -- Hydrocodone-Tussionex -- Oxycodone-OxyContin -- Oxymorphone-Opana -- Buprenorphine-Suboxone -- Semisynthetic 4,5-Epoxymorphinan Derivatives (Antagonists) -- Morphinans -- Decahydroisoquinolines -- Benzomorphans -- 4-Phenylpiperidines -- 4-Anylinopiperidines -- Fentanyl-Fentora -- δ-Opioid Ligands -- κ-Opioid Ligands -- ORL-1-Opioid Ligands -- 3.3 ADJUNCTIVE AGENTS IN THE MANAGEMENT OF PAIN, OR "NONANALGESIC" PAIN KILLERS -- Antidepressants as Analgesics -- Miscellaneous Antidepressants -- Serotonin Norepinephrine Reuptake Inhibitors Combination with μ-Opioid Receptor Agonist (Tapentadol) -- Gabapentinoids (Calcium Channel α2δ Ligands) -- Pregabalin-Lyrica -- Calcium Channel Blockers -- Sodium Channel Blockers -- Potassium Channel Modulators -- Glutamate Receptor Modulators -- N-Methyl-d-Aspartate Antagonists α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Antagonists -- Kainate Receptor Antagonists -- TRPV1 Antagonists (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 Antagonists) -- α2-Adrenergic Agonists -- Modulators of Nicotinic Acetylcholine Receptors -- Neurokinin-1 Antagonists -- Cannabinoid Receptor Modulators -- Glial Inhibitors -- Cholecystokinin Antagonists -- Triptans -- Eletriptan-Relpax -- Rizatriptan-Maxalt -- REFERENCES -- 4 - Soporific Agents (Hypnotics and Sedative Drugs) -- 4.1 BARBITURATES -- 4.2 HISTAMINE H1 RECEPTOR ANTAGONISTS -- 4.3 BENZODIAZEPINES -- 4.4 Z-DRUGS -- Zolpidem-Ambien -- Eszopiclone-Lunesta -- 4.5 NEW GABA RECEPTOR AGONISTS -- 4.6 MELATONERGIC (MT1/MT2) AGONISTS -- 4.7 5-HT ANTAGONISTS AND ANTAGONISTS/INVERSE AGONISTS -- 4.8 NK1-RECEPTOR ANTAGONISTS -- 4.9 OREXIN RECEPTOR (OX1/OX2) ANTAGONISTS -- 4.10 SODIUM OXYBATE -- REFERENCES -- 5 - Anxiolytics (Tranquilizers) -- 5.1 BENZODIAZEPINES -- 5.2 ANXIOLYTIC DRUGS ACTING ON SEROTONIN RECEPTORS -- 5.3 ANXIOLYTIC DRUGS ACTING ON ADRENORECEPTORS -- 5.4 ANXIOLYTIC DRUGS ACTING ON GLUTAMATE RECEPTORS -- 5.5 ANXIOLYTIC COMPOUNDS ACTING ON OTHER RECEPTORS -- REFERENCES -- 6 - Antipsychotics -- 6.1 FIRST-GENERATION ANTIPSYCHOTICS -- Phenothiazines -- Thioxanthenes -- Butyrophenones -- Diphenylbutylpiperidines -- 6.2 SECOND-GENERATION ANTIPSYCHOTICS -- Dibenzodiazepines, Dibenzoxazepines, Dibenzothiazepines, and Benzothienodiazepines -- Quetiapine-Seroquel -- Olanzapine-Zyprexa -- Piperidinyl Isoxazoles, Piperazinyl Benzoisothiazoles, Piperidinylindoles -- Risperidone-Risperdal -- Sertindole-Serdolect -- Ziprasidone-Geodon -- Benzamides Sulpiride, Amisulpride -- 6.3 THIRD-GENERATION ANTIPSYCHOTICS -- Aripiprazole-Abilify -- REFERENCES -- 7 - Antidepressants -- 7.1 TRICYCLIC ANTIDEPRESSANTS -- 7.2 MONOAMINE OXIDASE INHIBITORS β Blockers with Vasodilator Action (Third-Generation β Blockers) -- β2 Adrenoblockers -- β3 Adrenoblockers -- Carvedilol-Coreg -- Nebivolol-Bystolic -- REFERENCES -- 13 - Cholinomimetics -- 13.1 DIRECT-ACTING CHOLINOMIMETICS -- Mixed AChR Agonists -- Nicotinic AChR Agonists -- Muscarinic AChR Agonists -- 13.2 CHOLINESTERASE INHIBITORS (INDIRECT-ACTING CHOLINOMIMETICS) -- Donepezil-Aricept -- REFERENCES -- 14 - Anticholinergic Drugs -- 14.1 ANTINICOTINIC AGENTS (NEUROMUSCULAR BLOCKING DRUGS) -- 14.2 GANGLIONIC BLOCKERS -- 14.3 ANTIMUSCARINIC AGENTS -- Tiotropium Bromide-Spiriva -- Darifenacin-Enablex -- Solifenacin-VESIcare -- Tolterodine-Detrol -- REFERENCES -- 15 - Centrally Acting Skeletal Muscle Relaxants -- Metaxalone-Skelaxin -- REFERENCES -- 16 - Antihistamine Drugs -- 16.1 H1 ANTIHISTAMINES -- Olopatadine-Patanol -- Levocetirizine-Xyzal -- 16.2 H2 ANTIHISTAMINES -- 16.3 H3 ANTIHISTAMINES -- 16.4 H4 ANTIHISTAMINES -- REFERENCES -- 17 - Cardiotonic Inotropic Drugs -- 17.1 CLASS I CARDIOTONIC INOTROPIC AGENTS (DRUGS THAT INCREASE THE CYCLIC ADENOSINE MONOPHOSPHATE LEVEL) -- Drugs That Increase Cyclic Adenosine Monophosphate Level By β-Receptor Stimulation -- Drugs That Increase Cyclic Adenosine Monophosphate Level By Stimulating Adenylyl Cyclase -- Phosphodiesterase Inhibitors -- 17.2 CLASS II CARDIOTONIC INOTROPIC AGENTS (DRUGS THAT REGULATE ION CHANNELS OR PUMPS IN THE MYOCARDIAL CELL MEMBRANE) -- 17.3 CLASS III CARDIOTONIC INOTROPIC AGENTS (DRUGS THAT MODULATE INTRACELLULAR CALCIUM REGULATION) -- 17.4 CLASS IV DRUGS THAT MODULATE INTRACELLULAR CALCIUM REGULATION AGENTS (DRUGS THAT AUGMENT CONTRACTILITY THROUGH VARIOUS MECH... -- REFERENCES -- 18 - Antiarrhythmic Drugs -- 18.1 CLASS I -- Class Ia (Sodium Channel Blockers with Intermediate Association/Dissociation Kinetics and Action Potential Duration) Class Ib (Sodium Channel Blockers with Rapid Association/Dissociation Kinetics) -- Class Ic (Sodium Channel Blockers with Slow Association/Dissociation Kinetics) -- 18.2 CLASS II -- 18.3 CLASS III -- 18.4 CLASS IV -- 18.5 CLASS V -- REFERENCES -- 19 - Antianginal Drugs -- 19.1 NITRATES -- 19.2 CALCIUM-CHANNEL BLOCKERS -- 19.3 Β-ADRENERGIC BLOCKERS -- 19.4 NOVEL ANTIANGINAL DRUGS -- Ranolazine-Ranexa -- REFERENCES -- 20 - Hypolipidemic and Antihyperlipidemic Drugs -- 20.1 STATINS -- Atorvastatin-Lipitor -- Rosuvastatin-Crestor -- 20.2 FIBRATES -- Fenofibrate-Tricor -- 20.3 BILE ACID SEQUESTRANTS -- Colesevelam-Welchol -- 20.4 EZETIMIBE-VYTORIN -- 20.5 NIACIN -- 20.6 OMEGA-3 FATTY ACIDS (FISH OILS) -- 20.7 NEW AGENTS FOR THE PHARMACOTHERAPY OF DYSLIPIDEMIA -- Microsomal Triglyceride Transfer Protein Inhibitors -- Squalene Synthase Inhibitors -- Preprotein Convertase Subtilisin Kexin-9 Inhibitors -- Antisense Oligonucleotide Therapies -- Cholesterol Ester Transfer Protein Inhibitors -- Peroxisomal Proliferator Activating Receptor-α and -γ Agonists -- REFERENCES -- 21 - Diuretics -- 21.1 CARBONIC ANHYDRASE INHIBITORS -- 21.2 LOOP DIURETICS (HIGH-CEILING DIURETICS) -- 21.3 DIURETICS ACTING AT THE DISTAL CONVOLUTED TUBULE -- Thiazides and Thiazide-Like Diuretics -- Thiazides -- Thiazide-Like Diuretics -- 21.4 DIURETICS ACTING AT THE COLLECTING DUCT SYSTEM -- Epithelial Sodium Channel Blockers -- Aldosterone Antagonists -- Vasopressin Antagonists -- 21.5 OSMOTIC DIURETICS -- 21.6 NOVEL DIURETIC TARGETS -- REFERENCES -- 22 - Antihypertensive Drugs -- 22.1 DIURETICS -- 22.2 Β BLOCKERS -- 22.3 CALCIUM-CHANNEL BLOCKERS -- 22.4 RENIN-ANGIOTENSIN SYSTEM BLOCKERS -- Angiotensin-Converting Enzyme Blockers -- Angiotensin II Receptor Blockers -- Losartan-Cozaar -- Olmesartan-Benicar -- Valsartan-Diovan -- Irbesartan-Avapro -- Telmisartan-Micardis |
| Title | Synthesis of Best-Seller Drugs |
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