Poison ivy/oak dermatitis. Use of polyamine salts of a linoleic acid dimer for topical prophylaxis

Closed patch tests were used to evaluate the ability of 156 different preparations (based on 22 different chemicals) to prevent poison ivy dermatitis. Several polyamine salts of a linoleic acid dimer were identified that were totally able to prevent the usual dermatitis in approximately 70% of subje...

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Vydané v:Archives of dermatology (1960) Ročník 122; číslo 7; s. 783
Hlavní autori: Orchard, S, Fellman, J H, Storrs, F J
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.07.1986
Predmet:
Adult
Dermatitis, Toxicodendron - prevention & control
Drug Combinations
Humans
Linoleic Acid
Linoleic Acids - therapeutic use
Middle Aged
Polyamines - therapeutic use
Polymers - therapeutic use
Propylene Glycols - therapeutic use
Skin Tests
ISSN:0003-987X
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Abstract Closed patch tests were used to evaluate the ability of 156 different preparations (based on 22 different chemicals) to prevent poison ivy dermatitis. Several polyamine salts of a linoleic acid dimer were identified that were totally able to prevent the usual dermatitis in approximately 70% of subjects. The effectiveness of the preparations improved when the antigen and the protectant were washed off within eight to 12 hours, instead of remaining on the skin for 48 hours. When washed off, and depending on the protectant, concentration, and vehicle used, several of the preparations were totally able to prevent a dermatitis in a range of 56% to 100% of subjects tested. Further work with these compounds may greatly benefit the many people currently plagued by their allergy to poison ivy and poison oak.
AbstractList Closed patch tests were used to evaluate the ability of 156 different preparations (based on 22 different chemicals) to prevent poison ivy dermatitis. Several polyamine salts of a linoleic acid dimer were identified that were totally able to prevent the usual dermatitis in approximately 70% of subjects. The effectiveness of the preparations improved when the antigen and the protectant were washed off within eight to 12 hours, instead of remaining on the skin for 48 hours. When washed off, and depending on the protectant, concentration, and vehicle used, several of the preparations were totally able to prevent a dermatitis in a range of 56% to 100% of subjects tested. Further work with these compounds may greatly benefit the many people currently plagued by their allergy to poison ivy and poison oak.
Author Storrs, F J
Fellman, J H
Orchard, S
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Snippet Closed patch tests were used to evaluate the ability of 156 different preparations (based on 22 different chemicals) to prevent poison ivy dermatitis. Several...
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SubjectTerms Adult
Dermatitis, Toxicodendron - prevention & control
Drug Combinations
Humans
Linoleic Acid
Linoleic Acids - therapeutic use
Middle Aged
Polyamines - therapeutic use
Polymers - therapeutic use
Propylene Glycols - therapeutic use
Skin Tests
Title Poison ivy/oak dermatitis. Use of polyamine salts of a linoleic acid dimer for topical prophylaxis
URI https://www.ncbi.nlm.nih.gov/pubmed/2942115
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