Clinicopathological investigations on mice envenomed with scorpion venom (Androctonus amoreuxi)

The present study assessed the toxicity of Androctonus amoreuxi crude venom on blood and biochemical serum parameters of mice. Adult male Albino mice were divided into three groups, in the control group mice were injected S.C. with saline solution. The second group and the third were injected with t...

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Published in:Journal of the Egyptian Society of Parasitology Vol. 42; no. 3; p. 515
Main Authors: Hamedy, A F, Kilany, Omnia E, Mohallal, Mahmoud E, Soliman, Belal A, Shoukry, Nahla M, Khaled, Howayda S
Format: Journal Article
Language:English
Published: Egypt 01.12.2012
Subjects:
Alanine Transaminase - blood
Alkaline Phosphatase - blood
Animals
Aspartate Aminotransferases - blood
Blood Chemical Analysis
Blood Proteins - analysis
Blood Proteins - drug effects
Creatinine - blood
Hematologic Tests
Kidney - drug effects
Kidney - physiology
Lethal Dose 50
Liver - drug effects
Liver - enzymology
Male
Mice
Scorpion Venoms - toxicity
Scorpions
Urea - blood
ISSN:1110-0583
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Abstract The present study assessed the toxicity of Androctonus amoreuxi crude venom on blood and biochemical serum parameters of mice. Adult male Albino mice were divided into three groups, in the control group mice were injected S.C. with saline solution. The second group and the third were injected with the venom S.C. in mice in the following doses 1/4 and 1/2 dose of LD50 respectively. Blood and serum samples were taken after 3 hours, 6 hours, 9 hours, 12 hours, 4 days and 7 days. Hematocrit (Ht), red blood cells (RBC) count, hemoglobin, MCV, MCH & MCHC were performed. Serum biochemical parameters, the levels of total proteins, albumin, globulin, glucose, cholesterol, triglycerides, ALT, AST, ALP, creatinine, uric acid and urea were measured. RBCs, Hob, PCV, MCV, MCH & MCHC showed significant increase, and increase in total protein, albumin and globulin within the experiment. Glucose and cholesterol levels were significantly increase from the beginning. Triglycerides showed significant decrease after 6 hours. Liver enzymes and kidney functions revealed significant changes post-injection.
AbstractList The present study assessed the toxicity of Androctonus amoreuxi crude venom on blood and biochemical serum parameters of mice. Adult male Albino mice were divided into three groups, in the control group mice were injected S.C. with saline solution. The second group and the third were injected with the venom S.C. in mice in the following doses 1/4 and 1/2 dose of LD50 respectively. Blood and serum samples were taken after 3 hours, 6 hours, 9 hours, 12 hours, 4 days and 7 days. Hematocrit (Ht), red blood cells (RBC) count, hemoglobin, MCV, MCH & MCHC were performed. Serum biochemical parameters, the levels of total proteins, albumin, globulin, glucose, cholesterol, triglycerides, ALT, AST, ALP, creatinine, uric acid and urea were measured. RBCs, Hob, PCV, MCV, MCH & MCHC showed significant increase, and increase in total protein, albumin and globulin within the experiment. Glucose and cholesterol levels were significantly increase from the beginning. Triglycerides showed significant decrease after 6 hours. Liver enzymes and kidney functions revealed significant changes post-injection.
The present study assessed the toxicity of Androctonus amoreuxi crude venom on blood and biochemical serum parameters of mice. Adult male Albino mice were divided into three groups, in the control group mice were injected S.C. with saline solution. The second group and the third were injected with the venom S.C. in mice in the following doses 1/4 and 1/2 dose of LD50 respectively. Blood and serum samples were taken after 3 hours, 6 hours, 9 hours, 12 hours, 4 days and 7 days. Hematocrit (Ht), red blood cells (RBC) count, hemoglobin, MCV, MCH & MCHC were performed. Serum biochemical parameters, the levels of total proteins, albumin, globulin, glucose, cholesterol, triglycerides, ALT, AST, ALP, creatinine, uric acid and urea were measured. RBCs, Hob, PCV, MCV, MCH & MCHC showed significant increase, and increase in total protein, albumin and globulin within the experiment. Glucose and cholesterol levels were significantly increase from the beginning. Triglycerides showed significant decrease after 6 hours. Liver enzymes and kidney functions revealed significant changes post-injection.The present study assessed the toxicity of Androctonus amoreuxi crude venom on blood and biochemical serum parameters of mice. Adult male Albino mice were divided into three groups, in the control group mice were injected S.C. with saline solution. The second group and the third were injected with the venom S.C. in mice in the following doses 1/4 and 1/2 dose of LD50 respectively. Blood and serum samples were taken after 3 hours, 6 hours, 9 hours, 12 hours, 4 days and 7 days. Hematocrit (Ht), red blood cells (RBC) count, hemoglobin, MCV, MCH & MCHC were performed. Serum biochemical parameters, the levels of total proteins, albumin, globulin, glucose, cholesterol, triglycerides, ALT, AST, ALP, creatinine, uric acid and urea were measured. RBCs, Hob, PCV, MCV, MCH & MCHC showed significant increase, and increase in total protein, albumin and globulin within the experiment. Glucose and cholesterol levels were significantly increase from the beginning. Triglycerides showed significant decrease after 6 hours. Liver enzymes and kidney functions revealed significant changes post-injection.
Author Mohallal, Mahmoud E
Hamedy, A F
Soliman, Belal A
Shoukry, Nahla M
Kilany, Omnia E
Khaled, Howayda S
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  givenname: Omnia E
  surname: Kilany
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  givenname: Howayda S
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  fullname: Khaled, Howayda S
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Snippet The present study assessed the toxicity of Androctonus amoreuxi crude venom on blood and biochemical serum parameters of mice. Adult male Albino mice were...
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SubjectTerms Alanine Transaminase - blood
Alkaline Phosphatase - blood
Animals
Aspartate Aminotransferases - blood
Blood Chemical Analysis
Blood Proteins - analysis
Blood Proteins - drug effects
Creatinine - blood
Hematologic Tests
Kidney - drug effects
Kidney - physiology
Lethal Dose 50
Liver - drug effects
Liver - enzymology
Male
Mice
Scorpion Venoms - toxicity
Scorpions
Urea - blood
Title Clinicopathological investigations on mice envenomed with scorpion venom (Androctonus amoreuxi)
URI https://www.ncbi.nlm.nih.gov/pubmed/23469627
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