Search Results - Tissue Array Analysis - methods

Inter-tissue glycan heterogeneity: site-specific glycoform analysis of mouse tissue N-glycoproteomes using MS1-based glycopeptide detection method assisted by lectin microarray: Inter-tissue glycan heterogeneity: site-specific glycoform analysis of mouse tissue N-glycoproteomes using MS1-based glycopeptide detection method assisted by lectin microarray by Nagai-Okatani, Chiaki, Tomioka, Azusa, Tominaga, Daisuke, Sakaue, Hiroaki, Kuno, Atsushi, Kaji, Hiroyuki

“…” of samples, we previously introduced an MS1-based glycopeptide detection method, “Glyco-RIDGE.” Here, to elucidate inter-tissue glycan heterogeneities, this estimation…”
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Automated Gleason grading of prostate cancer tissue microarrays via deep learning by Arvaniti, Eirini, Fricker, Kim S., Moret, Michael, Rupp, Niels, Hermanns, Thomas, Fankhauser, Christian, Wey, Norbert, Wild, Peter J., Rüschoff, Jan H., Claassen, Manfred

“… grading of prostate cancer tissue microarrays with Hematoxylin and Eosin (H&E) staining. Our system was trained using detailed Gleason annotations on a discovery…”
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Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform by Skardal, Aleksander, Murphy, Sean V., Devarasetty, Mahesh, Mead, Ivy, Kang, Hyun-Wook, Seol, Young-Joon, Shrike Zhang, Yu, Shin, Su-Ryon, Zhao, Liang, Aleman, Julio, Hall, Adam R., Shupe, Thomas D., Kleensang, Andre, Dokmeci, Mehmet R., Jin Lee, Sang, Jackson, John D., Yoo, James J., Hartung, Thomas, Khademhosseini, Ali, Soker, Shay, Bishop, Colin E., Atala, Anthony

“… One reason for such poor translation from drug candidate to successful use is a lack of model systems that accurately recapitulate normal tissue function of human organs and their response to drug compounds…”
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Claudin-18 expression in oesophagogastric adenocarcinomas: a tissue microarray study of 523 molecularly profiled cases by Coati, Irene, Lotz, Gábor, Fanelli, Giuseppe Nicolò, Brignola, Stefano, Lanza, Cristiano, Cappellesso, Rocco, Pellino, Antonio, Pucciarelli, Salvatore, Spolverato, Gaya, Guzzardo, Vincenza, Munari, Giada, Zaninotto, Giovanni, Scarpa, Marco, Mastracci, Luca, Farinati, Fabio, Realdon, Stefano, Pilati, Pierluigi, Lonardi, Sara, Valeri, Nicola, Rugge, Massimo, Kiss, Andras, Loupakis, Fotios, Fassan, Matteo

“… Methods We investigated the immunohistochemical profile of CLDN18, p53, p16, E-cadherin, MSH2, MSH6, MLH1, PSM2, HER2, and PDL-1 in a large series of 523 primary gastric carcinomas (GCs; n  = 408…”
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Data-analysis strategies for image-based cell profiling by Caicedo, Juan C, Cooper, Sam, Heigwer, Florian, Warchal, Scott, Qiu, Peng, Molnar, Csaba, Vasilevich, Aliaksei S, Barry, Joseph D, Bansal, Harmanjit Singh, Kraus, Oren, Wawer, Mathias, Paavolainen, Lassi, Herrmann, Markus D, Rohban, Mohammad, Hung, Jane, Hennig, Holger, Concannon, John, Smith, Ian, Clemons, Paul A, Singh, Shantanu, Rees, Paul, Horvath, Peter, Linington, Roger G, Carpenter, Anne E

“… The general workflow for this technology involves image acquisition with high-throughput microscopy systems and subsequent image processing and analysis…”
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histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data by Schapiro, Denis, Jackson, Hartland W, Raghuraman, Swetha, Fischer, Jana R, Zanotelli, Vito R T, Schulz, Daniel, Giesen, Charlotte, Catena, Raúl, Varga, Zsuzsanna, Bodenmiller, Bernd

“…The histology topography cytometry analysis toolbox (histoCAT) enables quantitative analysis and exploration of highly multiplexed imaging data for better understanding of individual cells in the context of tissue architecture…”
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Simultaneous epitope and transcriptome measurement in single cells by Stoeckius, Marlon, Hafemeister, Christoph, Stephenson, William, Houck-Loomis, Brian, Chattopadhyay, Pratip K, Swerdlow, Harold, Satija, Rahul, Smibert, Peter

“… Here, we describe cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq), a method in which oligonucleotide-labeled antibodies are used…”
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Probing the binding specificities of human Siglecs by cell-based glycan arrays by Büll, Christian, Nason, Rebecca, Sun, Lingbo, Van Coillie, Julie, Madriz Sørensen, Daniel, Moons, Sam J, Yang, Zhang, Arbitman, Steven, Fernandes, Steve M, Furukawa, Sanae, McBride, Ryan, Nycholat, Corwin M, Adema, Gosse J, Paulson, James C, Schnaar, Ronald L, Boltje, Thomas J, Clausen, Henrik, Narimatsu, Yoshiki

“…Siglecs are a family of sialic acid-binding receptors expressed by cells of the immune system and a few other cell types capable of modulating immune cell…”
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Tissue microarray validation in cervical carcinoma studies. A methodological approach by Lovane, Lucília, Carrilho, Carla, Karlsson, Christina

“…Tissue microarrays (TMAs) are a cost-effective tool to study biomarkers in clinical research. Cervical cancer (CC…”
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Classification of colorectal tissue images from high throughput tissue microarrays by ensemble deep learning methods by Nguyen, Huu-Giao, Blank, Annika, Dawson, Heather E., Lugli, Alessandro, Zlobec, Inti

“…Tissue microarray (TMA) core images are a treasure trove for artificial intelligence applications…”
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Tissue Microarrays by Dancau, Ana-Maria, Simon, Ronald, Mirlacher, Martina, Sauter, Guido

“… The tissue microarray technology greatly facilitates such analysis. In this method minute tissue samples (typically 0.6 mm in diameter…”
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A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications by Phan, Duc T T, Wang, Xiaolin, Craver, Brianna M, Sobrino, Agua, Zhao, Da, Chen, Jerry C, Lee, Lilian Y N, George, Steven C, Lee, Abraham P, Hughes, Christopher C W

“…, such that survival of the surrounding tissue is entirely dependent on delivery of nutrients through the vessels. Here we describe an arrayed version of the platform…”
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Statistical characterization and classification of colon microarray gene expression data using multiple machine learning paradigms by Maniruzzaman, Md, Jahanur Rahman, Md, Ahammed, Benojir, Abedin, Md. Menhazul, Suri, Harman S., Biswas, Mainak, El-Baz, Ayman, Bangeas, Petros, Tsoulfas, Georgios, Suri, Jasjit S.

“… A colon microarray data is a repository of thousands of gene expressions with different strengths for each cancer cell…”
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Quantification of Alzheimer disease neuropathology using tissue microarrays by Nguyen-Hao, Hoang-Tuong, Liu, Jie, Novelli, Mario, Maskey, Dhiraj, Schwartz, Raymond S, Harari, Oscar, Sutherland, Greg T

“… As a rapid research method to quantify hallmark pathologies and their relationships with the surrounding cytoarchitecture across the brain, we trialed tissue microarrays (TMAs…”
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A lung/liver-on-a-chip platform for acute and chronic toxicity studies by Bovard, David, Sandoz, Antonin, Luettich, Karsta, Frentzel, Stefan, Iskandar, Anita, Marescotti, Diego, Trivedi, Keyur, Guedj, Emmanuel, Dutertre, Quentin, Peitsch, Manuel C, Hoeng, Julia

“…The merging of three-dimensional in vitro models with multi-organ-on-a-chip (MOC) technology has taken in vitro assessment of chemicals to an unprecedented…”
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Virtual Tissue Microarrays for Validating Digital Biomarker Analysis in Colorectal Carcinoma by Jørgensen, Margarita Melnikova, Hamilton-Dutoit, Stephen Jacques, Bramsen, Jesper Bertram, Andersen, Claus Lindbjerg, Holm, Ida Elisabeth

“…Tissue microarrays (TMAs) are used for high-throughput biomarker discovery and validation…”
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Flexible Micro Spring Array Device for High-Throughput Enrichment of Viable Circulating Tumor Cells by Harouaka, Ramdane A, Zhou, Ming-Da, Yeh, Yin-Ting, Khan, Waleed J, Das, Avisnata, Liu, Xin, Christ, Christine C, Dicker, David T, Baney, Tara S, Kaifi, Jussuf T, Belani, Chandra P, Truica, Cristina I, El-Deiry, Wafik S, Allerton, Jeffrey P, Zheng, Si-Yang

“… CTCs have been established as a cancer biomarker of known prognostic value. The enrichment of viable CTCs for ex vivo analysis could further improve cancer diagnosis and guide treatment selection…”
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Immune Biomarkers on Tissue Microarray Cores Support the Presence of Adjacent Tertiary Lymphoid Structures in Soft Tissue Sarcoma by Shenasa, Elahe, Thornton, Shelby, Gao, Dongxia, Kommoss, Felix K F, Nielsen, Torsten O

“… Although tissue microarrays (TMAs) could facilitate this assessment, it is unclear whether small microarray cores can represent and identify associated TLS responses…”
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Pooled CRISPR screens with imaging on microraft arrays reveals stress granule-regulatory factors by Wheeler, Emily C., Vu, Anthony Q., Einstein, Jaclyn M., DiSalvo, Matthew, Ahmed, Noorsher, Van Nostrand, Eric L., Shishkin, Alexander A., Jin, Wenhao, Allbritton, Nancy L., Yeo, Gene W.

“… However, many biologically relevant cell states involve cellular and subcellular changes that are only accessible by microscopic visualization, and are currently impossible to screen with pooled methods…”
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Microfluidic blood–brain barrier model provides in vivo‐like barrier properties for drug permeability screening by Wang, Ying I., Abaci, Hasan Erbil, Shuler, Michael L.

“…Efficient delivery of therapeutics across the neuroprotective blood–brain barrier (BBB) remains a formidable challenge for central nervous system drug…”
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