Výsledky vyhľadávania - Research Network of Computational and Structural Biotechnology

Unlocking COVID therapeutic targets: A structure-based rationale against SARS-CoV-2, SARS-CoV and MERS-CoV Spike Autor Trigueiro-Louro, João, Correia, Vanessa, Figueiredo-Nunes, Inês, Gíria, Marta, Rebelo-de-Andrade, Helena

“…[Display omitted] •Human SARSr-CoV Spike protein is highly conserved in both S1 and S2 subunits.•The S1-RBD, -SD1; S2-CR, -HR1 and -CH are the most promising…”
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Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer Autor Győrffy, Balázs

“…[Display omitted] Extensive research is directed to uncover new biomarkers capable to stratify breast cancer patients into clinically relevant cohorts…”
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UCell: Robust and scalable single-cell gene signature scoring Autor Andreatta, Massimo, Carmona, Santiago J.

“…UCell is an R package for evaluating gene signatures in single-cell datasets. UCell signature scores, based on the Mann-Whitney U statistic, are robust to…”
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Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model Autor Beck, Bo Ram, Shin, Bonggun, Choi, Yoonjung, Park, Sungsoo, Kang, Keunsoo

“…•The MT-DTI deep learning model was used to identify potent drugs for SARS-CoV-2.•Atazanavir, remdesivir, and Kaletra were predicted to inhibit…”
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The DisGeNET cytoscape app: Exploring and visualizing disease genomics data Autor Piñero, Janet, Saüch, Josep, Sanz, Ferran, Furlong, Laura I.

“…Thanks to the unbiased exploration of genomic variants at large scale, hundreds of thousands of disease-associated loci have been uncovered. In parallel,…”
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Integration strategies of multi-omics data for machine learning analysis Autor Picard, Milan, Scott-Boyer, Marie-Pier, Bodein, Antoine, Périn, Olivier, Droit, Arnaud

“…Schematic representation of the main strategies for multi-omics datasets integration. A) Early integration concatenates all omics datasets into a single matrix…”
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From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways Autor Wang, Yaqiu, Kanneganti, Thirumala-Devi

“…[Display omitted] Pyroptosis, apoptosis and necroptosis are the most genetically well-defined programmed cell death (PCD) pathways, and they are intricately…”
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The oralome and its dysbiosis: New insights into oral microbiome-host interactions Autor Radaic, Allan, Kapila, Yvonne L.

“…[Display omitted] The oralome is the summary of the dynamic interactions orchestrated between the ecological community of oral microorganisms (comprised of up…”
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The language of proteins: NLP, machine learning & protein sequences Autor Ofer, Dan, Brandes, Nadav, Linial, Michal

“…Natural language processing (NLP) is a field of computer science concerned with automated text and language analysis. In recent years, following a series of…”
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Review on circular RNAs and new insights into their roles in cancer Autor Tang, Xiaozhu, Ren, Hongyan, Guo, Mengjie, Qian, Jinjun, Yang, Ye, Gu, Chunyan

“…[Display omitted] Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA molecules derived from exonic or intronic sequences by…”
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Machine Learning Methods for Histopathological Image Analysis Autor Komura, Daisuke, Ishikawa, Shumpei

“…Abundant accumulation of digital histopathological images has led to the increased demand for their analysis, such as computer-aided diagnosis using machine…”
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Multi-omics approaches in cancer research with applications in tumor subtyping, prognosis, and diagnosis Autor Menyhárt, Otília, Győrffy, Balázs

“…•Single-level data analysis produced by high-throughput technologies is limited by showing only a narrow window of cellular functions.•Data integration across…”
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Prediction of HER2-positive breast cancer recurrence and metastasis risk from histopathological images and clinical information via multimodal deep learning Autor Yang, Jialiang, Ju, Jie, Guo, Lei, Ji, Binbin, Shi, Shufang, Yang, Zixuan, Gao, Songlin, Yuan, Xu, Tian, Geng, Liang, Yuebin, Yuan, Peng

“…[Display omitted] HER2-positive breast cancer is a highly heterogeneous tumor, and about 30% of patients still suffer from recurrence and metastasis after…”
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Fates of CD8+ T cells in Tumor Microenvironment Autor Maimela, Nomathamsanqa Resegofetse, Liu, Shasha, Zhang, Yi

“…Studies have reported a positive correlation between elevated CD8+ T cells in the tumor microenvironment (TME) and good prognosis in cancer. However, the…”
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Benchmarking of Nanopore R10.4 and R9.4.1 flow cells in single-cell whole-genome amplification and whole-genome shotgun sequencing Autor Ni, Ying, Liu, Xudong, Simeneh, Zemenu Mengistie, Yang, Mengsu, Li, Runsheng

“…Third-generation sequencing can be used in human cancer genomics and epigenomic research. Oxford Nanopore Technologies (ONT) recently released R10.4 flow cell,…”
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Machine learning applications in cancer prognosis and prediction Autor Kourou, Konstantina, Exarchos, Themis P., Exarchos, Konstantinos P., Karamouzis, Michalis V., Fotiadis, Dimitrios I.

“…Cancer has been characterized as a heterogeneous disease consisting of many different subtypes. The early diagnosis and prognosis of a cancer type have become…”
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Farnesoid X receptor (FXR): Structures and ligands Autor Jiang, Longying, Zhang, Huajun, Xiao, Desheng, Wei, Hudie, Chen, Yongheng

“…[Display omitted] Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly expressed in the liver and intestine. Upon ligand…”
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CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy Autor Xu, Yuanyuan, Li, Zhanjun

“…Genome editing is the modification of genomic DNA at a specific target site in a wide variety of cell types and organisms, including insertion, deletion and…”
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Constructing knowledge graphs and their biomedical applications Autor Nicholson, David N., Greene, Casey S.

“…Knowledge graphs can support many biomedical applications. These graphs represent biomedical concepts and relationships in the form of nodes and edges. In this…”
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Chemokines and chemokine receptors during COVID-19 infection Autor Khalil, Bariaa A., Elemam, Noha Mousaad, Maghazachi, Azzam A.

“…[Display omitted] Chemokines are crucial inflammatory mediators needed during an immune response to clear pathogens. However, their excessive release is the…”
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