Výsledky vyhľadávania - 생화학분자생물학회

Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes Autor Luong Dai Ly, Shanhua Xu, 최성경, 하채명, THOUDAMTHEMIS, 차승규, Andreas Wiederkehr, Claes B. Wollheim, 이인규, 박규상

“…Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and ATP synthesis but also cause serious stress to various tissues,…”
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Pluripotent stem cell-derived chimeric antigen receptor-natural killer cells targeting epidermal growth factor receptor 2 for cancer immunotherapy Autor Han, Jongsuk, Jin, Chaeyeon, Hwang, Sae-Byeok, Lee, In Jee, Baek, Young Seok, Jung, Daun, Kim, Ki Yeon, Mitalipov, Shoukhrat, Kim, Ji Hyang, An, Hee Jung, Lee, Yeonmi, Kang, Eunju

“…Chimeric antigen receptor-natural killer (CAR-NK) cells are emerging as a promising platform for allogeneic, cell-based immunotherapy. Among available sources,…”
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Toward unraveling molecular grammars for dsRNA-binding proteins: substrate recognition to binding mechanisms Autor Jeon, Jaemin, Kim, Yoosik

“…Long double-stranded RNAs (dsRNAs) are recognized by innate immune response proteins, thereby initiating the integrated stress response. As these RNAs adopt an…”
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Alloxan attenuates glucosamine-induced NF-κB activation and proinflammatory gene expression under normoglycemic conditions Autor Kim, Sang-Min, Lee, Chanhaeng, Kim, Dong Yeol, Han, Inn-Oc

“…Glucosamine (GlcN), a critical substrate in the hexosamine biosynthetic pathway, is known to modulate inflammatory responses in macrophages depending on…”
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Systems memory consolidation during sleep: oscillations, neuromodulators, and synaptic remodeling Autor Jaekyung Kim, Minjeong Park

“…Memory consolidation transforms newly acquired experiences into stable long-term memories essential for learning and cognition. This process involves systems…”
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Functional analysis of secreted tissue inhibitor of metalloproteinases-1 from adult human neural stem cells (ahNSCs) for regeneration and neuroprotection Autor Kyeung Min Joo, Ki Hoon Kim, Dong Geun Hong, Hye Yun Chae, Dong Oh Kim, So Heun Lee, Chung Kwon Kim, Geun-hyoung Ha

“…The adult human neural stem cell (ahNSC)-conditioned medium (CM) contains various secreted factors that promote tissue repair and neuroprotection. This study…”
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N-acetyl-L-alanine ameliorates atopic dermatitis-like symptoms by suppressing Th2 differentiation in DNFB-induced NC/Nga mice Autor Uyanga Tsogt, Seung-gook Kim, Suhong Duan, Hyung-jin Lim, Jiaying Bao, Hwa-ryung Song, Jong-suk Kim, Myung-kwan Han

“…Atopic dermatitis (AD) is a chronic dermatological disorder characterized by intense pruritus and eczematous lesions. Repeated topical application of…”
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Ubiquitination and ubiquitin-like modifications in metabolic dysfunction-associated steatotic liver disease: mechanisms and implications Autor Hyunjin Rho, Uijin Kim, Jaewhan Song

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is a complex metabolic disorder that encompasses a spectrum of conditions, from simple hepatic…”
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Roles of RNA modifications in aging and age-related diseases Autor Eunseok Kang, Rosa Haque, Hanseul Lee, Seung-jae V. Lee

“…RNA modifications are key epigenetic alterations that play regulatory functions in RNA biology, including RNA stability and translation. Emerging evidence…”
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Erratum to: Decoding tau acetylation in Alzheimer’s disease and tauopathies: from site-specific mechanisms to therapeutic horizons Autor Yoonah R. Oh, Min-kyoo Shin

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Metal-stabilized G-quadruplexes: biological insights and sensing applications Autor Seongmin Kim, Dahoon Kim, Yoori Kim

“…Repeat sequences account for approximately 45% of the human genome, and can produce noncanonical DNA secondary structures that include G-quadruplexes (G4s)…”
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The antioxidant effects of decursin inhibit EndMT progression through PI3K/AKT/NF-kB and Smad signaling pathways Autor Ran Kim, Sejin Kim, Hojin Kim, Seongtae Jeong, Hanbyeol Moon, Jongmin Kim, Byeong-wook Song, Woochul Chang

“…Endothelial cells (ECs) undergo endothelial-to-mesenchymal transition (EndMT) during the pathophysiology of cardiovascular diseases, a complex cellular…”
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Decoding tau acetylation in Alzheimer’s disease and tauopathies: from site-specific mechanisms to therapeutic horizons Autor Yoonah R. Oh, Min-kyoo Shin

“…Tau acetylation has been recognized as a pivotal post-translational modification associated with the pathogenesis of Alzheimer’s disease (AD) and other…”
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Contribution of histone deacetylases (HDACs) to the regulation of histone and non-histone proteins: implications for fibrotic diseases Autor Sunyoung Jang, Nayun Choi, Jong Hoon Park, Kyung Hyun Yoo

“…Histone deacetylases (HDACs) are essential enzymes that play a pivotal role in the epigenetic regulation of gene expression by catalyzing the removal of acetyl…”
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Erratum to: Modulating CD226 and PD-(L)1 pathways improves CMV-specific CD8 ＋ T cell responses in the absence of IL-2 Autor Hye-in Sim, Yunju Jo, Hyejin Ahn, Juyeon Hong, Hye-bin Kim, Bohwan Yun, Haeun Son, Yeonjun Jeong, Jibaek Kim, Chan-sik Park, Yoon Park, Hyung-seung Jin

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Cannabidiol as a therapeutic agent for rosacea through simultaneous inhibition of multiple inflammatory pathways Autor Chandani Shrestha, Eun Hee Yoo, Barsha Deshar, Min Hwang, Shinwon Kang, Bum-ho Bin, Ji Hyun Lee, Jiyoon Kim

“…Rosacea is a chronic inflammatory skin disorder characterized by facial erythema, papules, pustules, and telangiectasia, affecting approximately 5.5% of the…”
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In vivo exosome imaging: applications of diverse visualization techniques Autor Seongje Hong, Hyun Chul Jo, Hye-lin Kim, Hyeonah Kim, Jangwoo Lee, Juhyeong Jeon, Jiho Rhim, Siyeon Rhee, Jinbong Park, Yoon Hee Chung, Kyung Oh Jung

“…Exosomes―nanoscale extracellular vesicles secreted by various cell types―play a crucial role in intercellular communication by delivering biologically active…”
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Kinetic basis for Cas12a off-target discrimination Autor Yuyoung Kim, You Hee Choi, Minji Kim, Yunsu Jang, Sanghwa Lee

“…CRISPR-Cas12a proteins are RNA-guided endonucleases classified as type V-A effectors that function similarly to Cas9, but possess distinct biochemical…”
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Ubiquitin specific protease 7 deubiquitinates and regulates Aurora B-mediated cytokinesis Autor Kamini Kaushal, Ainsley Mike Antao, Soumyadip Das, Sammy L. Kim, Girish Birappa, Sripriya Rajkumar, D. A. Ayush Gowda, C. Bindu Ajaykumar, Vijai Singh, Keesung Kim, Bharathi Suresh, Suresh Ramakrishna

“…Aurora B is a widely studied mitotic checkpoint kinase that forms a part of the chromosomal passenger complex. The entry to and exit from mitosis are…”
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Auranofin, an antirheumatic drug, shows anticancer stem cell potential via suppression of the Stat3 signal Autor Seung-yeon Ko, Yuna Kim, Jin Sun Chung, Young Bin Kim, Su-lim Kim, Dong-sun Lee, Kyung-hee Chun, Hack Sun Choi

“…Accumulating data have shown that targeting breast cancer stem cells (CSCs) is an auspicious way for anticancer therapies. This study demonstrated that the…”
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