Výsledky vyhledávání - (integrative OR integration) computational algorithm

Principles for Integrative Structural Biology Studies Autor Rout, Michael P, Sali, Andrej

“…Integrative structure determination is a powerful approach to modeling the structures of biological systems based on data produced by multiple experimental and theoretical methods, with implications…”
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Pan-cancer integrative histology-genomic analysis via multimodal deep learning Autor Chen, Richard J, Lu, Ming Y, Williamson, Drew F K, Chen, Tiffany Y, Lipkova, Jana, Noor, Zahra, Shaban, Muhammad, Shady, Maha, Williams, Mane, Joo, Bumjin, Mahmood, Faisal

“…The rapidly emerging field of computational pathology has demonstrated promise in developing objective prognostic models from histology images…”
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Machine Learning and Integrative Analysis of Biomedical Big Data Autor Mirza, Bilal, Wang, Wei, Wang, Jie, Choi, Howard, Chung, Neo Christopher, Ping, Peipei

“… However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies…”
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IGCN: integrative graph convolution networks for patient level insights and biomarker discovery in multi-omics integration Autor Ozdemir, Cagri, Vashishath, Yashu, Bozdag, Serdar, Ozdemir, Cagri, Vashishath, Yashu, Bozdag, Serdar

“…Developing computational tools for integrative analysis across multiple types of omics data has been of immense importance in cancer molecular biology and precision medicine research…”
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Computational Approaches for Integrative Analysis of the Metabolome and Microbiome Autor Chong, Jasmine, Xia, Jianguo

“… In this review, we provide an overview of different computational approaches that have been used in recent years for integrative…”
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MINT: a multivariate integrative method to identify reproducible molecular signatures across independent experiments and platforms Autor Rohart, Florian, Eslami, Aida, Matigian, Nicholas, Bougeard, Stéphanie, Lê Cao, Kim-Anh

“… One solution is to combine independent studies into a single integrative analysis, additionally increasing sample size…”
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Effective Integration of Single-Cell Multi-Omics Data Using Improved Network-Based Integrative Clustering with Multigraph Regularization Autor Zhang, Shunqin, Kong, Wei, Wang, Shuaiqun, Wei, Kai, Liu, Kun, Wen, Gen, Yu, Yaling

“… and reveal the pathogenesis of Alzheimer's disease (AD) from two perspectives. However, implementing such algorithms faces challenges such as high data noise levels, increased dimensionality, and computational complexity…”
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scGRNom: a computational pipeline of integrative multi-omics analyses for predicting cell-type disease genes and regulatory networks Autor Jin, Ting, Rehani, Peter, Ying, Mufang, Huang, Jiawei, Liu, Shuang, Roussos, Panagiotis, Wang, Daifeng

“… To address this, we developed a computational pipeline, scGRNom ( s ingle- c ell G ene R egulatory N etwork prediction from multi- om ics…”
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fuseMLR: an R package for integrative prediction modeling of multi-omics data Autor Fouodo, Césaire J. K., Bleskina, Marina, Szymczak, Silke

“…, different types or modalities of molecular data. Integrative predictive modeling of such data is particularly challenging…”
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An integrative Bayesian Dirichlet-multinomial regression model for the analysis of taxonomic abundances in microbiome data Autor Wadsworth, W. Duncan, Argiento, Raffaele, Guindani, Michele, Galloway-Pena, Jessica, Shelburne, Samuel A., Vannucci, Marina

“…, allergy and cancer. Integrative approaches which aim at associating the composition of the human microbiome with other available information, such as clinical covariates and environmental predictors, are paramount…”
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Why imaging data alone is not enough: AI-based integration of imaging, omics, and clinical data Autor Holzinger, Andreas, Haibe-Kains, Benjamin, Jurisica, Igor

“… to provide the best possible treatment. In addition to the need for sufficient computing resources, suitable algorithms, models, and data infrastructure, three important aspects are often neglected: (1…”
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Comparative analysis of integrative classification methods for multi-omics data Autor Novoloaca, Alexei, Broc, Camilo, Beloeil, Laurent, Yu, Wen-Han, Becker, Jérémie

“… In this work, we present a thorough comparison of a selection of six methods, representative of the main families of intermediate integrative approaches…”
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Probabilistic integrative modeling of genome-scale metabolic and regulatory networks in Escherichia coli and Mycobacterium tuberculosis Autor Chandrasekaran, Sriram, Price, Nathan D

“… A cardinal challenge in obtaining accurate predictions is the integration of transcriptional regulatory networks with the corresponding metabolic network…”
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An integrative knowledge graph for rare diseases, derived from the Genetic and Rare Diseases Information Center (GARD) Autor Zhu, Qian, Nguyen, Dac-Trung, Grishagin, Ivan, Southall, Noel, Sid, Eric, Pariser, Anne

“… have not been able to keep pace. Through determining the applicability of computational approaches to enhance or replace manual curation tasks, we aim to both improve the sustainability and relevance of consumer health information…”
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G-DOC Plus – an integrative bioinformatics platform for precision medicine Autor Bhuvaneshwar, Krithika, Belouali, Anas, Singh, Varun, Johnson, Robert M., Song, Lei, Alaoui, Adil, Harris, Michael A., Clarke, Robert, Weiner, Louis M., Gusev, Yuriy, Madhavan, Subha

“…Background G-DOC Plus is a data integration and bioinformatics platform that uses cloud computing and other advanced computational tools to handle a variety of biomedical BIG DATA including gene…”
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MultiGATE: integrative analysis and regulatory inference in spatial multi-omics data via graph representation learning Autor Miao, Jishuai, Li, Jinzhao, Xin, Jingxue, Tu, Jiajuan, Ge, Muyang, Qi, Ji, Zhou, Xiaocheng, Zhu, Ying, Yang, Can, Lin, Zhixiang

“… The key feature of MultiGATE is that it simultaneously performs embedding of the spatial pixels and infers the cross-modality regulatory relationship, which allows deeper data integration…”
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Unveiling hidden connections in omics data via pyPARAGON: an integrative hybrid approach for disease network construction Autor Arici, Muslum Kaan, Tuncbag, Nurcan

“…Abstract Network inference or reconstruction algorithms play an integral role in successfully analyzing and identifying causal relationships between omics hits for detecting dysregulated and altered…”
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Network-based multi-omics integrative analysis methods in drug discovery: a systematic review Autor Jiang, Wei, Ye, Weicai, Tan, Xiaoming, Bao, Yun-Juan

“…The integration of multi-omics data from diverse high-throughput technologies has revolutionized drug discovery…”
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Genome structure determination via 3C-based data integration by the Integrative Modeling Platform Autor Bau, Davide, Marti-Renom, Marc A

“… Here we describe a computational module of the Integrative Modeling Platform (IMP, http://www.integrativemodeling.org) that uses chromosome conformation capture…”
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SpaOmicsVAE: A deep learning framework for integrative analysis of spatial multi-omics data Autor Zhang, Zhiwei, Wang, Mengqiu, Zhang, Xinxin, Dai, Ruoyan, Wang, Zhenghui, Lei, Lixin, Li, Zhenxing, Han, Kaitai, Wang, Zijun, Shi, Chaojing, Guo, Qianjin

“… However, the effective integration and analysis of these complex datasets remain challenging…”
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