Suchergebnisse - "von Herrath, Matthias"

Type 1 diabetes: etiology, immunology, and therapeutic strategies von van Belle, Tom L, Coppieters, Ken T, von Herrath, Matthias G

“… Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of the beta-cells in the islets of Langerhans results in insulin …”
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Increased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes von Rodriguez-Calvo, Teresa, Ekwall, Olov, Amirian, Natalie, Zapardiel-Gonzalo, Jose, von Herrath, Matthias G

“… Type 1 diabetes (T1D) results from a complex interplay between genetic susceptibility and environmental factors that have been implicated in the pathogenesis …”
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HLA class I hyper-expression unmasks beta cells but not alpha cells to the immune system in pre-diabetes von Benkahla, Mehdi A., Sabouri, Somayeh, Kiosses, William B., Rajendran, Sakthi, Quesada-Masachs, Estefania, von Herrath, Matthias G.

“… Human leukocyte antigens of class-I (HLA-I) molecules are hyper-expressed in insulin-containing islets (ICI) of type 1 diabetic (T1D) donors. This study …”
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New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes von Bender, Christine, Rajendran, Sakthi, von Herrath, Matthias G.

“… Since the establishment of the network for pancreatic organ donors with diabetes (nPOD), we have gained unprecedented insight into the pathology of human type …”
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Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets von Van Belle, Tom L, Nierkens, Stefan, Arens, Ramon, von Herrath, Matthias G

“… It remains unclear how interleukin-21 receptor (IL-21R) contributes to type 1 diabetes. Here we have shown that dendritic cells (DCs) in the pancreas required …”
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α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes von Brissova, Marcela, Haliyur, Rachana, Saunders, Diane, Shrestha, Shristi, Dai, Chunhua, Blodgett, David M., Bottino, Rita, Campbell-Thompson, Martha, Aramandla, Radhika, Poffenberger, Gregory, Lindner, Jill, Pan, Fong Cheng, von Herrath, Matthias G., Greiner, Dale L., Shultz, Leonard D., Sanyoura, May, Philipson, Louis H., Atkinson, Mark, Harlan, David M., Levy, Shawn E., Prasad, Nripesh, Stein, Roland, Powers, Alvin C.

“… Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of C-peptide long after disease onset but develop an inadequate glucagon …”
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Pancreatic Tissue Transplanted in TheraCyte™ Encapsulation Devices Is Protected and Prevents Hyperglycemia in a Mouse Model of Immune-Mediated Diabetes von Boettler, Tobias, Schneider, Darius, Cheng, Yang, Kadoya, Kuniko, Brandon, Eugene P., Martinson, Laura, Von Herrath, Matthias

“… Type 1 diabetes (T1D) is characterized by destruction of glucose-responsive insulin-producing pancreatic β-cells and exhibits immune infiltration of pancreatic …”
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Potential viral pathogenic mechanism in human type 1 diabetes von Schneider, Darius A., von Herrath, Matthias G.

“… In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8 + T cells, together with a significant number of other inflammatory …”
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Resolution of a chronic viral infection after interleukin-10 receptor blockade von Ejrnaes, Mette, Filippi, Christophe M, Martinic, Marianne M, Ling, Eleanor M, Togher, Lisa M, Crotty, Shane, von Herrath, Matthias G

“… A defining characteristic of persistent viral infections is the loss and functional inactivation of antiviral effector T cells, which prevents viral clearance …”
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Enterovirus infection and type 1 diabetes: closing in on a link? von Rodriguez-Calvo, Teresa, von Herrath, Matthias G

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Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease von Fujinami, Robert S, von Herrath, Matthias G, Christen, Urs, Whitton, J Lindsay

“… Virus infections and autoimmune disease have long been linked. These infections often precede the occurrence of inflammation in the target organ. Several …”
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Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase von Rodriguez-Calvo, Teresa, Suwandi, Jessica S, Amirian, Natalie, Zapardiel-Gonzalo, Jose, Anquetil, Florence, Sabouri, Somayeh, von Herrath, Matthias G

“… Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells are destroyed in the islets of Langerhans. One of its main pathological …”
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Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions von Renard, Catherine B., Kramer, Farah, Johansson, Fredrik, Lamharzi, Najib, Tannock, Lisa R., Herrath, Matthias G. von, Chait, Alan, Bornfeldt, Karin E.

“… Diabetes in humans accelerates cardiovascular disease caused by atherosclerosis. The relative contributions of hyperglycemia and dyslipidemia to …”
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Regulatory Immune Mechanisms beyond Regulatory T Cells von Christoffersson, Gustaf, von Herrath, Matthias

“… In autoimmunity, aggressive immune responses are counteracted by suppressive rejoinders. For instance, FOXP3-expressing regulatory T cells (Tregs), have shown …”
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Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection von Holdener, Martin, Hintermann, Edith, Bayer, Monika, Rhode, Antje, Rodrigo, Evelyn, Hintereder, Gudrun, Johnson, Eric F, Gonzalez, Frank J, Pfeilschifter, Josef, Manns, Michael P, Herrath, Matthias von G, Christen, Urs

“… Autoimmune liver diseases, such as autoimmune hepatitis (AIH) and primary biliary cirrhosis, often have severe consequences for the patient. Because of a lack …”
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Viral infections and molecular mimicry in type 1 diabetes von Coppieters, Ken T., Wiberg, Anna, von Herrath, Matthias G.

“… Type 1 diabetes (T1D) is a disease characterized by inflammation of pancreatic islets associated with autoimmunity against insulin‐producing beta cells, …”
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Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 Diabetes von Pham, Minh N., von Herrath, Matthias G., Vela, Jose Luis

“… Regulatory T cells (Tregs) play an important role in preventing effector T-cell (Teff) targeting of self-antigens that can lead to tissue destruction in …”
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Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes? von Rodriguez-Calvo, Teresa, Christoffersson, Gustaf, Bender, Christine, von Herrath, Matthias G., Mallone, Roberto, Kent, Sally C., James, Eddie A.

“… In human type 1 diabetes and animal models of the disease, a diverse assortment of immune cells infiltrates the pancreatic islets. CD8 + T cells are well …”
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Recent advances in understanding Type 1 Diabetes [version 1; peer review: 2 approved] von Christoffersson, Gustaf, Rodriguez-Calvo, Teresa, von Herrath, Matthias

“… Type 1 diabetes is a multifactorial disease in which genetic and environmental factors play a key role. The triggering event is still obscure, and so are many …”
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OX40 Facilitates Control of a Persistent Virus Infection von Boettler, Tobias, Moeckel, Friedrich, Cheng, Yang, Heeg, Maximilian, Salek-Ardakani, Shahram, Crotty, Shane, Croft, Michael, von Herrath, Matthias G.

“… During acute viral infections, clearance of the pathogen is followed by the contraction of the anti-viral T cell compartment. In contrast, T cell responses …”
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