Suchergebnisse - "van der Poll, Tom"

Ultrafast long-range charge separation in organic semiconductor photovoltaic diodes von Gélinas, Simon, Rao, Akshay, Kumar, Abhishek, Smith, Samuel L, Chin, Alex W, Clark, Jenny, van der Poll, Tom S, Bazan, Guillermo C, Friend, Richard H

“… Understanding the charge-separation mechanism in organic photovoltaic cells (OPVs) could facilitate optimization of their overall efficiency. Here we report …”
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Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo von van Zoelen, Marieke A D, Yang, Huan, Florquin, Sandrine, Meijers, Joost C M, Akira, Shizuo, Arnold, Bernd, Nawroth, Peter P, Bierhaus, Angelika, Tracey, Kevin J, van der Poll, Tom

“… High-mobility group box 1 (HMGB-1) has been reported as a "late" proinflammatory mediator in sepsis. In vitro data have shown that HMGB-1 can induce activation …”
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Pathogenesis and pathophysiology of pneumococcal meningitis von Mook-Kanamori, Barry B, Geldhoff, Madelijn, van der Poll, Tom, van de Beek, Diederik

“… Pneumococcal meningitis continues to be associated with high rates of mortality and long-term neurological sequelae. The most common route of infection starts …”
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The coagulation system and its function in early immune defense von van der Poll, Tom, Herwald, Heiko

“… Blood coagulation has a Janus-faced role in infectious diseases. When systemically activated, it can cause serious complications associated with high morbidity …”
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The role of platelets in sepsis von de Stoppelaar, Sacha F, van 't Veer, Cornelis, van der Poll, Tom

“… Platelets are small circulating anucleate cells that are of crucial importance in haemostasis. Over the last decade, it has become increasingly clear that …”
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Critically ill patients demonstrate large interpersonal variation in intestinal microbiota dysregulation: a pilot study von Lankelma, Jacqueline M., van Vught, Lonneke A., Belzer, Clara, Schultz, Marcus J., van der Poll, Tom, de Vos, Willem M., Wiersinga, W. Joost

“… Purpose The intestinal microbiota has emerged as a virtual organ with essential functions in human physiology. Antibiotic-induced disruption of the microbiota …”
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A short contemporary history of disseminated intravascular coagulation von Levi, Marcel, van der Poll, Tom

“… Disseminated intravascular coagulation (DIC) is a syndrome characterized by systemic intravascular activation of coagulation, leading to a widespread …”
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Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia von van der Sluijs, Koenraad F, Nijhuis, Monique, Levels, Johannes H M, Florquin, Sandrine, Mellor, Andrew L, Jansen, Henk M, van der Poll, Tom, Lutter, René

“… Airway infection with influenza virus induces local expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO), which has been shown to …”
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Asthma and coagulation von de Boer, J Daan, Majoor, Christof J, van 't Veer, Cornelis, Bel, Elisabeth H D, van der Poll, Tom

“… Asthma is a chronic airway disease characterized by paroxysmal airflow obstruction evoked by irritative stimuli on a background of allergic lung inflammation …”
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Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis von Brouwer, Matthijs C, de Gans, Jan, Heckenberg, Sebastiaan GB, Zwinderman, Aeilko H, van der Poll, Tom, van de Beek, Diederik

“… Streptococcus pneumoniae and Neisseria meningitidis can cause sepsis and meningitis. Several risk factors for pneumococcal and meningococcal disease have been …”
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Severe Sepsis and Septic Shock von Angus, Derek C, van der Poll, Tom

“… Sepsis, a complex physiological and metabolic response to infection, is a common reason for admission to an intensive care unit. This review examines the …”
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Ventilator-induced lung injury is mediated by the NLRP3 inflammasome von Kuipers, Maria T, Aslami, Hamid, Janczy, John R, van der Sluijs, Koenraad F, Vlaar, Alexander P J, Wolthuis, Esther K, Choi, Goda, Roelofs, Joris J T H, Flavell, Richard A, Sutterwala, Fayyaz S, Bresser, Paul, Leemans, Jaklien C, van der Poll, Tom, Schultz, Marcus J, Wieland, Catharina W

“… The innate immune response is important in ventilator-induced lung injury (VILI) but the exact pathways involved are not elucidated. The authors studied the …”
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Proteomic profiling of neutrophils and plasma in community-acquired pneumonia reveals crucial proteins in diverse biological pathways linked to clinical outcome von Michels, Erik H. A., Chouchane, Osoul, de Brabander, Justin, de Vos, Alex F., Faber, Daniël R., Douma, Renée A., Smit, Eva R., Wiersinga, W. Joost, Biggelaar, Maartje van den, Poll, Tom van der, Hoogendijk, Arie J.

“… Neutrophils play a dichotomous role in community-acquired pneumonia (CAP), providing protection and potentially causing damage. Existing research on neutrophil …”
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Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia von Schuurman, Alex R, Reijnders, Tom DY, Saris, Anno, Ramirez Moral, Ivan, Schinkel, Michiel, de Brabander, Justin, van Linge, Christine, Vermeulen, Louis, Scicluna, Brendon P, Wiersinga, W Joost, Vieira Braga, Felipe A, van der Poll, Tom

“… The exact immunopathophysiology of community-acquired pneumonia (CAP) caused by SARS-CoV-2 (COVID-19) remains clouded by a general lack of relevant disease …”
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Burkholderia pseudomallei tropism and the melioidosis road map von Wiersinga, W Joost, van der Poll, Tom

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Sepsis: deriving biological meaning and clinical applications from high-dimensional data von Schuurman, Alex R., Reijnders, Tom D. Y., Kullberg, Robert F. J., Butler, Joe M., van der Poll, Tom, Wiersinga, W. Joost

“… The pathophysiology of sepsis is multi-facetted and highly complex. As sepsis is a leading cause of global mortality that still lacks targeted therapies, …”
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The gut microbiota as a modulator of innate immunity during melioidosis von Lankelma, Jacqueline M., Birnie, Emma, Weehuizen, Tassili A. F., Scicluna, Brendon P., Belzer, Clara, Houtkooper, Riekelt H., Roelofs, Joris J. T. H., de Vos, Alex F., van der Poll, Tom, Budding, Andries E., Wiersinga, W. Joost

“… Melioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is an emerging cause of pneumonia-derived sepsis in the tropics. The gut …”
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Coagulation and sepsis von Levi, Marcel, van der Poll, Tom

“… Severe sepsis is almost invariably associated with systemic activation of coagulation. There is ample evidence that demonstrates a wide-ranging cross-talk …”
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Expression profile and function of triggering receptor expressed on myeloid cells-1 during melioidosis von Wiersinga, W Joost, Veer, Cees van T, Wieland, Catharina W, Gibot, Sebastien, Hooibrink, Berend, Day, Nicholas P, Peacock, Sharon J, van der Poll, Tom

“… Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies Toll-like receptor-initiated responses against pathogens. We aimed to characterize TREM-1 …”
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The Long Non-Coding Antisense RNA JHDM1D-AS1 Regulates Inflammatory Responses in Human Monocytes von Malmström, Erik, Khan, Hina N., Veer, Cornelis van ‘t, Stunnenberg, Melissa, Meijer, Mariska T., Matsumoto, Hisatake, Otto, Natasja A., Geijtenbeek, Teunis B. H., de Vos, Alex F., Poll, Tom van der, Scicluna, Brendon P.

“… Monocytes are key players in innate immunity, with their ability to regulate inflammatory responses and combat invading pathogens. There is a growing body of …”
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