Suchergebnisse - "van der Poll, T"

The impact of diabetes on the pathogenesis of sepsis von Koh, G. C. K. W., Peacock, S. J., van der Poll, T., Wiersinga, W. J.

“… Diabetes is associated with an increased susceptibility to infection and sepsis. Conflicting data exist on whether the mortality of patients with sepsis is …”
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Endothelial barrier dysfunction in septic shock von Opal, S. M., Poll, T.

“… The endothelium provides an essential and selective membrane barrier that regulates the movement of water, solutes, gases, macromolecules and the cellular …”
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The influence of corticosteroids on hemostasis in healthy subjects von Majoor, C. J., Sneeboer, M. M. S., Kievit, A., Meijers, J. C. M., Poll, T., Lutter, R., Bel, E. H., Kamphuisen, P. W.

“… Essentials Corticosteroids are associated with venous thromboembolism in patients with inflammatory diseases. Healthy subjects received 0.5 mg kg−1 of …”
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Thrombin contributes to protective immunity in pneumonia‐derived sepsis via fibrin polymerization and platelet–neutrophil interactions von Claushuis, T. A. M., Stoppelaar, S. F., Stroo, I., Roelofs, J. J. T. H., Ottenhoff, R., Poll, T., Veer, C.

“… Essentials Immunity and coagulation are linked during sepsis but the role of thrombin is not fully elucidated. We investigated the effect of thrombin …”
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The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice von van Westerloo, David J, Giebelen, Ilona A, Florquin, Sandrine, Bruno, Marco J, Larosa, Gregory J, Ulloa, Luis, Tracey, Kevin J, van der Poll, T

“… The nervous system, through the vagus nerve, controls inflammation by decreasing the release of tumor necrosis factor-alpha from endotoxin stimulated …”
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New insights into pathways that determine the link between infection and thrombosis von Levi, M, van der Poll, T, Schultz, M

“… Severe infection is often linked to prothrombotic events. Indeed, haemostatic abnormalities are encountered in most cases of infection, ranging from an …”
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mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin von Ramirez-Moral, I., Yu, X., Butler, J.M., van Weeghel, M., Otto, N.A., Ferreira, B. Lima, Maele, L. Van, Sirard, J.C., de Vos, A.F., de Jong, M.D., Houtkooper, R.H., van der Poll, T.

“… Human bronchial epithelial (HBE) cells play an essential role during bacterial infections of the airways by sensing pathogens and orchestrating protective …”
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Rage signalling promotes intestinal tumourigenesis von Heijmans, J, Büller, N V J A, Hoff, E, Dihal, A A, van der Poll, T, van Zoelen, M A D, Bierhaus, A, Biemond, I, Hardwick, J C H, Hommes, D W, Muncan, V, van den Brink, G R

“… Development of colon cancer is a multistep process that is regulated by intrinsic and extrinsic cellular signals. Extrinsic factors include molecular patterns …”
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Rapid outer-surface protein C DNA tattoo vaccination protects against Borrelia afzelii infection von Wagemakers, A, Mason, L M K, Oei, A, de Wever, B, van der Poll, T, Bins, A D, Hovius, J W R

“… Borrelia afzelii is the predominant Borrelia species causing Lyme borreliosis in Europe. Currently there is no human vaccine against Lyme borreliosis, and most …”
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Coagulation and inflammation in scrub typhus and murine typhus—a prospective comparative study from Laos von Paris, D.H., Chansamouth, V., Nawtaisong, P., Löwenberg, E.C., Phetsouvanh, R., Blacksell, S.D., Lee, S.J., Dondorp, A.M., Newton, P.N., van der Poll, T., Levi, M., Day, N. P.J.

“… Scrub typhus (caused by Orientia tsutsugamushi) and murine typhus (caused by Rickettsia typhi) cause up to 28% of febrile episodes in Thailand and Laos. The …”
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Effect of acute hyperglycaemia and/or hyperinsulinaemia on proinflammatory gene expression, cytokine production and neutrophil function in humans von Stegenga, M. E., Crabben, S. N. van der, Dessing, M. C., Pater, J. M., Van Den Pangaart, P. S., De Vos, A. F., Tanck, M. W., Roos, D., Sauerwein, H. P., Van Der Poll, T.

“… Aims  Type 2 diabetes is frequently associated with infectious complications. Swift activation of leucocytes is important for an adequate immune response. We …”
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Lung Microbiota Predict Clinical Outcomes in Critically Ill Patients von Dickson, Robert P, Schultz, Marcus J, van der Poll, Tom, Schouten, Laura R, Falkowski, Nicole R, Luth, Jenna E, Sjoding, Michael W, Brown, Christopher A, Chanderraj, Rishi, Huffnagle, Gary B, Bos, Lieuwe D J

“… Recent studies have revealed that, in critically ill patients, lung microbiota are altered and correlate with alveolar inflammation. The clinical significance …”
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Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis von Bos, L D, Schouten, L R, van Vught, L A, Wiewel, M A, Ong, D S Y, Cremer, O, Artigas, A, Martin-Loeches, I, Hoogendijk, A J, van der Poll, T, Horn, J, Juffermans, N, Calfee, C S, Schultz, M J

“… RationaleWe hypothesised that patients with acute respiratory distress syndrome (ARDS) can be clustered based on concentrations of plasma biomarkers and that …”
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Vagus nerve stimulation inhibits activation of coagulation and fibrinolysis during endotoxemia in rats von VAN WESTERLOO, D. J., GIEBELEN, I. A. J., MEIJERS, J. C. M., DAALHUISEN, J., DE VOS, A. F., LEVI, M., VAN DER POLL, T.

“… Background: Sepsis and endotoxemia are associated with concurrent activation of inflammation and the hemostatic mechanism, which both contribute to organ …”
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Toll-like receptor mRNA levels in alveolar macrophages after inhalation of endotoxin von Maris, N A, Dessing, M C, de Vos, A F, Bresser, P, van der Zee, J S, Jansen, H M, Spek, C A, van der Poll, T

“… Toll-like receptors (TLRs) are pattern-recognition receptors that have been implicated in the initiation of innate immune responses upon the first encounter …”
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Antiinflammatory effects of reconstituted high-density lipoprotein during human endotoxemia von Pajkrt, D, Doran, J E, Koster, F, Lerch, P G, Arnet, B, van der Poll, T, ten Cate, J W, van Deventer, S J

“… High-density lipoprotein (HDL) has been found to neutralize LPS activity in vitro and in animals in vivo. We sought to determine the effects of reconstituted …”
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Non-conventional immunomodulation in the management of sepsis von Slim, M.A., Turgman, O., van Vught, L.A., van der Poll, T., Wiersinga, W.J.

“… Sepsis remains a critical global health issue, demanding novel therapeutic strategies. Traditional immunomodulation treatments such as corticosteroids, …”
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Characteristics of AIDS patients in Dutch intensive care units von Huson, M.A.M., Bakhshi-Raiez, F., Grobusch, M.P., de Jonge, E., de Keizer, N.F., van der Poll, T.

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The influence of HIV infection on coagulation activation during sepsis von Huson, M.A.M., Kalkman, R., Alabi, A.S., Beyeme, J.O., Grobusch, M.P., Meijers, J.C.M., van der Poll, T.

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The role of plasminogen activator inhibitor type 1 in the inflammatory response to local tissue injury von RENCKENS, R., ROELOFS, J. J. T. H., DE WAARD, V., FLORQUIN, S., LIJNEN, H. R., CARMELIET, P., VAN DER POLL, T.

“… Background: The plasma levels of the plasminogen activator‐inhibitor type 1 (PAI‐1) are consistently elevated in patients with sterile tissue injury, often …”
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