Suchergebnisse - "van den Broek, Bram"

Parallel Nanometric 3D Tracking of Intracellular Gold Nanorods Using Multifocal Two-Photon Microscopy von van den Broek, Bram, Ashcroft, Brian, Oosterkamp, Tjerk H, van Noort, John

“… We report a novel technique for long-term parallel three dimensional (3D)-tracking of gold nanorods in live cells with nanometer resolution. Gold nanorods …”
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Optimizing Imaging Conditions for Demanding Multi-Color Super Resolution Localization Microscopy von Nahidiazar, Leila, Agronskaia, Alexandra V., Broertjes, Jorrit, van den Broek, Bram, Jalink, Kees

“… Single Molecule Localization super-resolution Microscopy (SMLM) has become a powerful tool to study cellular architecture at the nanometer scale. In SMLM, …”
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Sensitivity of CT, MRI, and EUS-FNA/B in the preoperative workup of histologically proven left-sided pancreatic lesions von Gorris, Myrte, Janssen, Quisette P., Besselink, Marc G., van den Broek, Bram L.J., van Eijck, Casper H.J., van Gils, Marjon J., Koerkamp, Bas Groot, Struik, Femke, van Driel, Lydi M.J.W., van Hooft, Jeanin E.

“… Left-sided pancreatic lesions are often treated surgically. Accurate diagnostic work-up is therefore essential to prevent futile major abdominal surgery. Large …”
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Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer von Prekovic, Stefan, Schuurman, Karianne, Mayayo-Peralta, Isabel, Manjón, Anna G., Buijs, Mark, Yavuz, Selçuk, Wellenstein, Max D., Barrera, Alejandro, Monkhorst, Kim, Huber, Anne, Morris, Ben, Lieftink, Cor, Chalkiadakis, Theofilos, Alkan, Ferhat, Silva, Joana, Győrffy, Balázs, Hoekman, Liesbeth, van den Broek, Bram, Teunissen, Hans, Debets, Donna O., Severson, Tesa, Jonkers, Jos, Reddy, Timothy, de Visser, Karin E., Faller, William, Beijersbergen, Roderick, Altelaar, Maarten, de Wit, Elzo, Medema, Rene, Zwart, Wilbert

“… The glucocorticoid receptor (GR) regulates gene expression, governing aspects of homeostasis, but is also involved in cancer. Pharmacological GR activation is …”
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Dynamic FRET-FLIM based screening of signal transduction pathways von Harkes, Rolf, Kukk, Olga, Mukherjee, Sravasti, Klarenbeek, Jeffrey, van den Broek, Bram, Jalink, Kees

“… Fluorescence Lifetime Imaging (FLIM) is an intrinsically quantitative method to screen for protein–protein interactions and is frequently used to record the …”
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Facilitated diffusion with DNA coiling von Lomholt, Michael A, van den Broek, Bram, Kalisch, Svenja-Marei J, Wuite, Gijs J L, Metzler, Ralf

“… When DNA-binding proteins search for their specific binding site on a DNA molecule they alternate between linear 1-dimensional diffusion along the DNA …”
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Nationwide outcomes of 1000 robotic pancreatoduodenectomies across the four phases of the learning curve von Emmen, Anouk M L H, van den Broek, Bram L J, Hendriks, Tessa E, Busch, Olivier R, Bonsing, Bert A, Cappelle, Marie L, Coene, Peter-Paul L O, Festen, Sebastiaan, van der Harst, Erwin, de Hingh, Ignace H J T, van Laarhoven, Cees J H M, Lips, Daan J, Sprakel, Joost, Luyer, Misha D P, Mieog, J Sven D, van Santvoort, Hjalmar C, van der Schelling, George, Wijsman, Jan H, Patijn, Gijs A, de Wilde, Roeland F, Zwart, Maurice J W, Derksen, Wouter J M, Molenaar, I Quintus, Groot Koerkamp, Bas, Besselink, Marc G

“… Abstract Background Robotic pancreatoduodenectomy (RPD) is increasingly being implemented to enhance patient recovery, but it is unclear what happens to …”
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WAPL-mediated removal of cohesin protects against segregation errors and aneuploidy von Haarhuis, Judith H I, Elbatsh, Ahmed M O, van den Broek, Bram, Camps, Daniel, Erkan, Hasan, Jalink, Kees, Medema, René H, Rowland, Benjamin D

“… The classical X shape of mitotic human chromosomes is the consequence of two distinct waves of cohesin removal. First, during prophase and prometaphase, the …”
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Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells von van Veen, Michiel, Matas-Rico, Elisa, van de Wetering, Koen, Leyton-Puig, Daniela, Kedziora, Katarzyna M, De Lorenzi, Valentina, Stijf-Bultsma, Yvette, van den Broek, Bram, Jalink, Kees, Sidenius, Nicolai, Perrakis, Anastassis, Moolenaar, Wouter H

“… The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and …”
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PFA fixation enables artifact-free super-resolution imaging of the actin cytoskeleton and associated proteins von Leyton-Puig, Daniela, Kedziora, Katarzyna M., Isogai, Tadamoto, van den Broek, Bram, Jalink, Kees, Innocenti, Metello

“… Super-resolution microscopy (SRM) allows precise localization of proteins in cellular organelles and structures, including the actin cytoskeleton. Yet sample …”
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Endoscopic ultrasonography as additional preoperative workup is valuable in half of the patients with a pancreatic body or tail lesion von Janssen, Quisette P, Gorris, Myrte, van den Broek, Bram L J, Besselink, Marc G, Busch, Olivier R, van Eijck, Casper H J, Groot Koerkamp, Bas, van Hooft, Jeanin E, van Driel, Lydi M J W

“… The management of pancreatic body and tail lesions is underexposed. It remains unclear whether endoscopic ultrasonography (EUS) increases the accuracy of the …”
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The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80 von Typas, Dimitris, Luijsterburg, Martijn S., Wiegant, Wouter W., Diakatou, Michaela, Helfricht, Angela, Thijssen, Peter E., van den Broek, Bram, Mullenders, Leon H., van Attikum, Haico

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Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality von Gogola, Ewa, Duarte, Alexandra A, de Ruiter, Julian R, Wiegant, Wouter W, Schmid, Jonas A, de Bruijn, Roebi, James, Dominic I, Guerrero Llobet, Sergi, Vis, Daniel J, Annunziato, Stefano, van den Broek, Bram, Barazas, Marco, Kersbergen, Ariena, van de Ven, Marieke, Tarsounas, Madalena, Ogilvie, Donald J, van Vugt, Marcel, Wessels, Lodewyk F A, Bartkova, Jirina, Gromova, Irina, Andújar-Sánchez, Miguel, Bartek, Jiri, Lopes, Massimo, van Attikum, Haico, Borst, Piet, Jonkers, Jos, Rottenberg, Sven

“… Inhibitors of poly(ADP-ribose) (PAR) polymerase (PARPi) have recently entered the clinic for the treatment of homologous recombination (HR)-deficient cancers …”
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Flat clathrin lattices are dynamic actin-controlled hubs for clathrin-mediated endocytosis and signalling of specific receptors von Leyton-Puig, Daniela, Isogai, Tadamoto, Argenzio, Elisabetta, van den Broek, Bram, Klarenbeek, Jeffrey, Janssen, Hans, Jalink, Kees, Innocenti, Metello

“… Clathrin lattices at the plasma membrane coat both invaginated and flat regions forming clathrin-coated pits and clathrin plaques, respectively. The function …”
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REV7 counteracts DNA double-strand break resection and affects PARP inhibition von Xu, Guotai, Chapman, J. Ross, Brandsma, Inger, Yuan, Jingsong, Mistrik, Martin, Bouwman, Peter, Bartkova, Jirina, Gogola, Ewa, Warmerdam, Daniël, Barazas, Marco, Jaspers, Janneke E., Watanabe, Kenji, Pieterse, Mark, Kersbergen, Ariena, Sol, Wendy, Celie, Patrick H. N., Schouten, Philip C., van den Broek, Bram, Salman, Ahmed, Nieuwland, Marja, de Rink, Iris, de Ronde, Jorma, Jalink, Kees, Boulton, Simon J., Chen, Junjie, van Gent, Dik C., Bartek, Jiri, Jonkers, Jos, Borst, Piet, Rottenberg, Sven

“… Loss of REV7 is shown to regulate end resection of double-stranded DNA breaks in BRCA1-deficient cells, leading to PARP inhibitor resistance and restoration of …”
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Tissue patrol by resident memory CD8+ T cells in human skin von Dijkgraaf, Feline E., Matos, Tiago R., Hoogenboezem, Mark, Toebes, Mireille, Vredevoogd, David W., Mertz, Marjolijn, van den Broek, Bram, Song, Ji-Ying, Teunissen, Marcel B. M., Luiten, Rosalie M., Beltman, Joost B., Schumacher, Ton N.

“… Emerging data show that tissue-resident memory T (T RM ) cells play an important protective role at murine and human barrier sites. T RM cells in the epidermis …”
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Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence von Lenain, Christelle, Gusyatiner, Olga, Douma, Sirith, van den Broek, Bram, Peeper, Daniel S

“… Cellular senescence is a largely irreversible form of cell cycle arrest triggered by various types of damage and stress, including oncogene expression (termed …”
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A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing von Vizoso, Miguel, E. J. Pritchard, Colin, Bombardelli, Lorenzo, van den Broek, Bram, Krimpenfort, Paul, Beijersbergen, Roderick L., Jalink, Kees, van Rheenen, Jacco

“… The experimental need to engineer the genome both in time and space, has led to the development of several photoactivatable Cre recombinase systems. However, …”
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IL-7Rα on CD4+ T cells is required for their survival and the pathogenesis of experimental autoimmune encephalomyelitis von Azizi, Gholamreza, Van den Broek, Bram, Ishikawa, Larissa Lumi Watanabe, Naziri, Hamed, Yazdani, Reza, Zhang, Guang-Xian, Ciric, Bogoljub, Rostami, Abdolmohamad

“… Background The IL-7 receptor alpha (IL-7Rα) binds both IL-7 and thymic stromal lymphopoietin (TSLP). IL-7Rα is essential for the development and survival of …”
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Video Grading of Pancreatic Anastomoses During Robotic Pancreatoduodenectomy to Assess both Learning Curve and the Risk of Pancreatic Fistula - A Post Hoc Analysis of the LAELAPS-3 Training Program von van den Broek, Bram L J, Zwart, Maurice J W, Bonsing, Bert A, Busch, Olivier R, van Dam, Jacob L, de Hingh, Ignace H J T, Hogg, Melissa E, Luyer, Misha D, Mieog, J S D, Stibbe, Luna A, Takagi, Kosei, Tran, T C K, de Wilde, Roeland F, Zeh, 3rd, Herbert J, Zureikat, Amer H, Groot Koerkamp, Bas, Besselink, Marc G

“… To assess the learning curve of pancreaticojejunostomy during robotic pancreatoduodenectomy(RPD) and to predict the risk of postoperative pancreatic …”
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