Suchergebnisse - "van den Berk, Paul C. M."

Differential Programming of B Cells in AID Deficient Mice von Hogenbirk, Marc A., Heideman, Marinus R., Velds, Arno, van den Berk, Paul CM, Kerkhoven, Ron M., van Steensel, Bas, Jacobs, Heinz

“… The Aicda locus encodes the activation induced cytidine deaminase (AID) and is highly expressed in germinal center (GC) B cells to initiate somatic …”
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Molecular dependencies and genomic consequences of a global DNA damage tolerance defect von de Groot, Daniel, Spanjaard, Aldo, Shah, Ronak, Kreft, Maaike, Morris, Ben, Lieftink, Cor, Catsman, Joyce J. I., Ormel, Shirley, Ayidah, Matilda, Pilzecker, Bas, Buoninfante, Olimpia Alessandra, van den Berk, Paul C. M., Beijersbergen, Roderick L., Jacobs, Heinz

“… Background DNA damage tolerance (DDT) enables replication to continue in the presence of fork stalling lesions. In mammalian cells, DDT is regulated by two …”
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A C57BL/6J Fancg-KO Mouse Model Generated by CRISPR/Cas9 Partially Captures the Human Phenotype von Shah, Ronak, van den Berk, Paul C. M., Pritchard, Colin E. J., Song, Ji-Ying, Kreft, Maaike, Pilzecker, Bas, Jacobs, Heinz

“… Fanconi anemia (FA) develops due to a mutation in one of the FANC genes that are involved in the repair of interstrand crosslinks (ICLs). FANCG, a member of …”
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HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: Existence of an alternative E3 ligase von Krijger, Peter H.L., Lee, Kyoo-Young, Wit, Niek, van den Berk, Paul C.M., Wu, Xiaoli, Roest, Henk P., Maas, Alex, Ding, Hao, Hoeijmakers, Jan H.J., Myung, Kyungjae, Jacobs, Heinz

“… DNA damage tolerance is regulated at least in part at the level of proliferating cell nuclear antigen (PCNA) ubiquitination. Monoubiquitination (PCNA-Ub) at …”
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PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance von Krijger, Peter H.L., van den Berk, Paul C.M., Wit, Niek, Langerak, Petra, Jansen, Jacob G., Reynaud, Claude-Agnès, de Wind, Niels, Jacobs, Heinz

“… ► Polη can be activated dependent and independent of PCNA-Ub during both SHM and DDT. ► PCNA-Ub and Polη are necessary, but not essential, for efficient DDT of …”
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Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine von Spanjaard, Aldo, Shah, Ronak, de Groot, Daniël, Buoninfante, Olimpia Alessandra, Morris, Ben, Lieftink, Cor, Pritchard, Colin, Zürcher, Lisa M, Ormel, Shirley, Catsman, Joyce J I, de Korte-Grimmerink, Renske, Siteur, Bjørn, Proost, Natalie, Boadum, Terry, van de Ven, Marieke, Song, Ji-Ying, Kreft, Maaike, van den Berk, Paul C M, Beijersbergen, Roderick L, Jacobs, Heinz

“… Crosslink repair depends on the Fanconi anemia pathway and translesion synthesis polymerases that replicate over unhooked crosslinks. Translesion synthesis is …”
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PrimPol prevents APOBEC/AID family mediated DNA mutagenesis von Pilzecker, Bas, Buoninfante, Olimpia Alessandra, Pritchard, Colin, Blomberg, Olga S., Huijbers, Ivo J., van den Berk, Paul C.M., Jacobs, Heinz

“… PrimPol is a DNA damage tolerant polymerase displaying both translesion synthesis (TLS) and (re)-priming properties. This led us to study the consequences of a …”
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The Fanconi Anemia Core Complex Is Dispensable during Somatic Hypermutation and Class Switch Recombination von Krijger, Peter H. L., Wit, Niek, van den Berk, Paul C. M., Jacobs, Heinz

“… To generate high affinity antibodies during an immune response, B cells undergo somatic hypermutation (SHM) of their immunoglobulin genes. Error-prone …”
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Lysine Residue 185 of Rad1 Is a Topological but Not a Functional Counterpart of Lysine Residue 164 of PCNA von Wit, Niek, Krijger, Peter H. L., van den Berk, Paul C. M., Jacobs, Heinz

“… Monoubiquitylation of the homotrimeric DNA sliding clamp PCNA at lysine residue 164 (PCNA(K164)) is a highly conserved, DNA damage-inducible process that is …”
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Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells von Lancini, Cesare, van den Berk, Paul C M, Vissers, Joseph H A, Gargiulo, Gaetano, Song, Ji-Ying, Hulsman, Danielle, Serresi, Michela, Tanger, Ellen, Blom, Marleen, Vens, Conchita, van Lohuizen, Maarten, Jacobs, Heinz, Citterio, Elisabetta

“… Histone ubiquitination at DNA breaks is required for activation of the DNA damage response (DDR) and DNA repair. How the dynamic removal of this modification …”
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Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation von Spanjaard, Aldo, Stratigopoulou, Maria, de Groot, Daniël, Aslam, Muhammad, van den Berk, Paul C. M., Stappenbelt, Chantal, Ayidah, Matilda, Catsman, Joyce J. I., Pardieck, Iris N., Kreft, Maaike, Arens, Ramon, Guikema, Jeroen E. J., Jacobs, Heinz

“… The development and differentiation of B cells is intimately linked to cell proliferation and the generation of diverse immunoglobulin gene ( Ig ) repertoires …”
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Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage von Wit, Niek, Buoninfante, Olimpia Alessandra, van den Berk, Paul C.M., Jansen, Jacob G., Hogenbirk, Marc A., de Wind, Niels, Jacobs, Heinz

“… Translesion synthesis (TLS) provides a highly conserved mechanism that enables DNA synthesis on a damaged template. TLS is performed by specialized DNA …”
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The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity von Will Castro, Luiza S. E. P., Pieters, Wietske, Alemdehy, Mir Farshid, Aslam, Muhammad A., Buoninfante, Olimpia Alessandra, Raaijmakers, Jonne A., Pilzecker, Bas, van den Berk, Paul C. M., te Riele, Hein, Medema, René H., Pedrosa, Rozangela C., Jacobs, Heinz

“… The antihelmintic drug ABZ and its metabolites belong to the chemical family of benzimidazoles (BZM) that act as potent tubulin polymerization inhibitors, …”
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Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair von Shah, Ronak, Aslam, Muhammad Assad, Spanjaard, Aldo, de Groot, Daniel, Zürcher, Lisa M, Altelaar, Maarten, Hoekman, Liesbeth, Pritchard, Colin E J, Pilzecker, Bas, van den Berk, Paul C M, Jacobs, Heinz

“… Abstract The Fanconi anemia (FA) repair pathway governs repair of highly genotoxic DNA interstrand crosslinks (ICLs) and relies on translesion synthesis (TLS) …”
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Mammalian life depends on two distinct pathways of DNA damage tolerance von Buoninfante, Olimpia Alessandra, Pilzecker, Bas, Spanjaard, Aldo, de Groot, Daniël, Prekovic, Stefan, Song, Ji-Ying, Lieftink, Cor, Ayidah, Matilda, Pritchard, Colin E J, Vivié, Judith, Mcgrath, Kathleen E, Huijbers, Ivo J, Philipsen, Sjaak, von Lindern, Marieke, Zwart, Wilbert, Beijersbergen, Roderick L, Palis, James, van den Berk, Paul C M, Jacobs, Heinz

“… DNA damage threatens genomic integrity and instigates stem cell failure. To bypass genotoxic lesions during replication, cells employ DNA damage tolerance …”
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The Ig heavy chain protein but not its message controls early B cell development von Aslam, Muhammad Assad, Alemdehy, Mir Farshid, Hao, Bingtao, Krijger, Peter H L, Pritchard, Colin E J, de Rink, Iris, Muhaimin, Fitriari Izzatunnisa, Nurzijah, Ika, van Baalen, Martijn, Kerkhoven, Ron M, van den Berk, Paul C M, Skok, Jane A, Jacobs, Heinz

“… Development of progenitor B cells (ProB cells) into precursor B cells (PreB cells) is dictated by immunoglobulin heavy chain checkpoint (IgHCC), where the IgHC …”
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Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation von Krijger, Peter H L, Langerak, Petra, van den Berk, Paul C M, Jacobs, Heinz

“… During somatic hypermutation (SHM), B cells introduce mutations into their immunoglobulin genes to generate high affinity antibodies. Current models suggest a …”
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Immunogenicity, including vitiligo, and feasibility of vaccination with autologous GM-CSF-transduced tumor cells in metastatic melanoma patients von Luiten, Rosalie M, Kueter, Esther W M, Mooi, Wolter, Gallee, Maarten P W, Rankin, Elaine M, Gerritsen, Winald R, Clift, Shirley M, Nooijen, Willem J, Weder, Pauline, van de Kasteele, Willeke F, Sein, Johan, van den Berk, Paul C M, Nieweg, Omgo E, Berns, Anton M, Spits, Hergen, de Gast, Gijsbert C

“… To determine the feasibility, toxicity, and immunologic effects of vaccination with autologous tumor cells retrovirally transduced with the GM-CSF gene, we …”
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Quantitative analysis by next generation sequencing of hematopoietic stem and progenitor cells (LSK) and of splenic B cells transcriptomes from wild-type and Usp3-knockout mice von Lancini, Cesare, Gargiulo, Gaetano, van den Berk, Paul C.M., Citterio, Elisabetta

“… The data described here provide genome-wide expression profiles of murine primitive hematopoietic stem and progenitor cells (LSK) and of B cell populations, …”
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Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system von Buoninfante, Olimpia Alessandra, Pilzecker, Bas, Aslam, Muhammad Assad, Zavrakidis, Ioannis, van der Wiel, Rianne, van de Ven, Marieke, van den Berk, Paul C M, Jacobs, Heinz

“… DNA damage tolerance (DDT) enables replication to continue in the presence of a damaged template and constitutes a key step in DNA interstrand crosslink …”
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