Suchergebnisse - "van de Ven, Rieneke"

The Immune Microenvironment in Head and Neck Squamous Cell Carcinoma: on Subsets and Subsites von Wondergem, Niels E., Nauta, Irene H., Muijlwijk, Tara, Leemans, C. René, van de Ven, Rieneke

“… Purpose To understand why some patients respond to immunotherapy but many do not, a clear picture of the tumor microenvironment (TME) of head and neck squamous …”
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Targeting C‐type lectin receptors: a high‐carbohydrate diet for dendritic cells to improve cancer vaccines von Dinther, Dieke, Stolk, Dorian A., Ven, Rieneke, Kooyk, Yvette, Gruijl, Tanja D., Haan, Joke M. M.

“… Review of in vivo targeting of tumor antigens to lectin receptors on antigen‐presenting cells using antibodies or ligands may improve the antitumor efficacy of …”
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Commentary on differential impact of TIM-3 ligands on NK cell function von van de Ven, Rieneke

“… T-cell immunoglobin and mucin-domain containing molecule 3 (TIM-3) is an immune checkpoint receptor and a target for immune checkpoint blockers (ICBs) …”
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Immunotherapy Goes Local: The Central Role of Lymph Nodes in Driving Tumor Infiltration and Efficacy von van Pul, Kim M., Fransen, Marieke F., van de Ven, Rieneke, de Gruijl, Tanja D.

“… Immune checkpoint blockade (ICB) has changed the therapeutic landscape of oncology but its impact is limited by primary or secondary resistance. ICB resistance …”
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Hallmarks of a genomically distinct subclass of head and neck cancer von Muijlwijk, Tara, Nauta, Irene H., van der Lee, Anabel, Grünewald, Kari J. T., Brink, Arjen, Ganzevles, Sonja H., Baatenburg de Jong, Robert J., Atanesyan, Lilit, Savola, Suvi, van de Wiel, Mark A., Peferoen, Laura A. N., Bloemena, Elisabeth, van de Ven, Rieneke, Leemans, C. René, Poell, Jos B., Brakenhoff, Ruud H.

“… Cancer is caused by an accumulation of somatic mutations and copy number alterations (CNAs). Besides mutations, these copy number changes are key …”
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Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche von Kos, Kevin, Aslam, Muhammad A., van de Ven, Rieneke, Wellenstein, Max D., Pieters, Wietske, van Weverwijk, Antoinette, Duits, Danique E.M., van Pul, Kim, Hau, Cheei-Sing, Vrijland, Kim, Kaldenbach, Daphne, Raeven, Elisabeth A.M., Quezada, Sergio A., Beyaert, Rudi, Jacobs, Heinz, de Gruijl, Tanja D., de Visser, Karin E.

“… Breast cancer is accompanied by systemic immunosuppression, which facilitates metastasis formation, but how this shapes organotropism of metastasis is poorly …”
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Guidelines for preparation and flow cytometry analysis of human nonlymphoid tissue DC von Dudziak, Diana, Heger, Lukas, Agace, William W, Bakker, Joyce, Gruijl, Tanja D., Dress, Regine J., Dutertre, Charles‐Antoine, Fenton, Thomas M., Fransen, Marieke F., Ginhoux, Florent, Heyman, Oded, Horev, Yael, Hornsteiner, Florian, Kandiah, Vinitha, Kles, Paz, Lubin, Ruth, Mizraji, Gabriel, Prokopi, Anastasia, Saar, Or, Sopper, Sieghart, Stoitzner, Patrizia, Strandt, Helen, Sykora, Martina M, Toffoli, Elisa C., Tripp, Christoph H., Pul, Kim, Ven, Rieneke, Wilensky, Asaf, Yona, Simon, Zelle‐Rieser, Claudia

“… This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state‐of‐the‐art protocols for the preparation, phenotype …”
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Author Correction: Hallmarks of a genomically distinct subclass of head and neck cancer von Muijlwijk, Tara, Nauta, Irene H., van der Lee, Anabel, Grünewald, Kari J. T., Brink, Arjen, Ganzevles, Sonja H., Baatenburg de Jong, Robert J., Atanesyan, Lilit, Savola, Suvi, van de Wiel, Mark A., Peferoen, Laura A. N., Bloemena, Elisabeth, van de Ven, Rieneke, Leemans, C. René, Poell, Jos B., Brakenhoff, Ruud H.

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Glycan-Modified Melanoma-Derived Apoptotic Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination von Horrevorts, Sophie K, Stolk, Dorian A, Ven, Rieneke van de, Hulst, Myrthe, Hof, Bert van Het, Duinkerken, Sanne, Heineke, Marieke H, Ma, Wenbin, Dusoswa, Sophie A, Nieuwland, Rienk, Garcia-Vallejo, Juan J, Loosdrecht, Arjan A van de, de Gruijl, Tanja D, Vliet, Sandra J van, van Kooyk, Yvette

“… Tumors that lack T cell infiltration are less likely to respond to immune checkpoint inhibition and could benefit from cancer vaccination for the initiation of …”
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Lipo-Based Vaccines as an Approach to Target Dendritic Cells for Induction of T- and iNKT Cell Responses von Stolk, Dorian A., de Haas, Aram, Vree, Jana, Duinkerken, Sanne, Lübbers, Joyce, van de Ven, Rieneke, Ambrosini, Martino, Kalay, Hakan, Bruijns, Sven, van der Vliet, Hans J., de Gruijl, Tanja D., van Kooyk, Yvette

“… In this study we developed a liposome-based vaccine containing palmitoylated synthetic long peptides (SLP) and alpha galactosylceramide (αGC) to specifically …”
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Glycan-Modified Apoptotic Melanoma-Derived Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination von Horrevorts, Sophie K., Stolk, Dorian A., van de Ven, Rieneke, Hulst, Myrthe, van Het Hof, Bert, Duinkerken, Sanne, Heineke, Marieke H., Ma, Wenbin, Dusoswa, Sophie A., Nieuwland, Rienk, Garcia-Vallejo, Juan J., van de Loosdrecht, Arjan A., de Gruijl, Tanja D., van Vliet, Sandra J., van Kooyk, Yvette

“… Tumors that lack T cell infiltration are less likely to respond to immune checkpoint inhibition and could benefit from cancer vaccination for the initiation of …”
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Exploring the impact of tertiary lymphoid structures maturity in NSCLC: insights from TLS scoring von Berthe, Julie, Poudel, Pawan, Segerer, Felix J., Jennings, Emily C., Ng, Felicia, Surace, Michael, Andoni, Alma, Testori, Marco, Saraiya, Megha, Vuko, Miljenka, Hessel, Harald, Heininen-Brown, Mari, Blando, Jorge, Jones, Emma V., Willis, Sophie E., Galon, Jérôme, van de Ven, Rieneke, de Gruijl, Tanja D., Angell, Helen K.

“… Tertiary Lymphoid Structures (TLS) are lymphoid structures commonly associated with improved survival of cancer patients and response to immunotherapies …”
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Exposure of CD34+ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy von van de Ven, Rieneke, Reurs, Anneke W., Wijnands, Pepijn G. J. T. B., van Wetering, Sandra, Kruisbeek, Ada M., Hooijberg, Erik, Scheffer, George L., Scheper, Rik J., de Gruijl, Tanja D.

“… Appropriate activation of dendritic cells (DC) is essential for successful active vaccination and induction of cell-mediated immunity. The scarcity of …”
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Editorial: Mechanisms of Lymphocyte Exclusion in the Tumor Microenvironment von van de Ven, Rieneke, Bifulco, Carlo B., Luke, Jason J., Church, Sarah E.

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Comparative phenotypic and functional analysis of migratory dendritic cell subsets from human oral mucosa and skin von Kosten, Ilona Jennifer, van de Ven, Rieneke, Thon, Maria, Gibbs, Susan, de Gruijl, Tanja D.

“… Antigen exposure to oral mucosa is generally thought to lead to immune tolerance induction. However, very little is known about the subset composition and …”
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Comparative analysis of immune infiltrates in head and neck cancers across anatomical sites von Muijlwijk, Tara, Nijenhuis, Dennis N L M, Ganzevles, Sonja H, Brink, Arjen, Ke, Changlin, Fass, Joseph N, Rajamanickam, Venkatesh, Leemans, C René, Koguchi, Yoshinobu, Fox, Bernard A, Poell, Jos B, Brakenhoff, Ruud H, van de Ven, Rieneke

“… BackgroundThe response rate to immune checkpoint inhibitors targeting programmed cell death 1 (PD-1) receptor is 13%–18% for patients with recurrent or …”
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Richness for Tumor-Infiltrating B-Cells in the Oral Cancer Tumor Microenvironment Is a Prognostic Factor in Early-Stage Disease and Improves Outcome in Advanced-Stage Disease von Nauta, Irene H., Nijenhuis, Dennis N. L. M., Ganzevles, Sonja H., Raaff, Pamela I., Kloosterman, Jan, Bloemena, Elisabeth, Brakenhoff, Ruud H., Leemans, C. René, van de Ven, Rieneke

“… Background/Objectives: Most studies on the interaction between the immune system and cancer focus on T-cells, whereas studies on tumor-infiltrating …”
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NK Cell-Dependent Antibody-Mediated Immunotherapy Is Improved In Vitro and In Vivo When Combined with Agonists for Toll-like Receptor 2 in Head and Neck Cancer Models von Gruijs, Mandy, Ganzevles, Sonja H., Stigter-van Walsum, Marijke, van der Mast, Richard, van Ostaijen-ten Dam, Monique M., Tuk, Cornelis W., Schilham, Marco W., Leemans, C. René, Brakenhoff, Ruud H., van Egmond, Marjolein, van de Ven, Rieneke, Bakema, Jantine E.

“… The immunosuppressive character of head and neck cancers may explain the relatively low response rates to antibody therapy targeting a tumor antigen, such as …”
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Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node von van Pul, Kim M., Vuylsteke, Ronald J.C.L.M., van de Ven, Rieneke, te Velde, Elisabeth A., Rutgers, Emiel J. Th, van den Tol, Petrousjka M., Stockmann, Hein B.A.C., de Gruijl, Tanja D.

“… Background Immune regulated pathways influence both breast cancer (BrC) development and response to (neo)adjuvant chemotherapy. The sentinel lymph node (SLN), …”
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Immune cell topography of head and neck cancer von Muijlwijk, Tara, Nijenhuis, Dennis N L M, Ganzevles, Sonja H, Ekhlas, Fatima, Ballesteros-Merino, Carmen, Peferoen, Laura A N, Bloemena, Elisabeth, Fox, Bernard A, Poell, Jos B, Leemans, C René, Brakenhoff, Ruud H, van de Ven, Rieneke

“… BackgroundApproximately 50% of head and neck squamous cell carcinomas (HNSCC) recur after treatment with curative intent. Immune checkpoint inhibitors are …”
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