Search Results - "van Pul, Kim"

Immunotherapy Goes Local: The Central Role of Lymph Nodes in Driving Tumor Infiltration and Efficacy by van Pul, Kim M., Fransen, Marieke F., van de Ven, Rieneke, de Gruijl, Tanja D.

“…Immune checkpoint blockade (ICB) has changed the therapeutic landscape of oncology but its impact is limited by primary or secondary resistance. ICB resistance…”
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Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node by van Pul, Kim M., Vuylsteke, Ronald J.C.L.M., van de Ven, Rieneke, te Velde, Elisabeth A., Rutgers, Emiel J. Th, van den Tol, Petrousjka M., Stockmann, Hein B.A.C., de Gruijl, Tanja D.

“…Background Immune regulated pathways influence both breast cancer (BrC) development and response to (neo)adjuvant chemotherapy. The sentinel lymph node (SLN),…”
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Breast cancer-induced immune suppression in the sentinel lymph node is effectively countered by CpG-B in conjunction with inhibition of the JAK2/STAT3 pathway by van Pul, Kim M, Vuylsteke, Ronald J C L M, de Beijer, Monique T A, van de Ven, Rieneke, van den Tol, M Petrousjka, Stockmann, Hein B A C, de Gruijl, Tanja D

“…BackgroundWe previously showed selectively hampered activation of lymph node-resident (LNR) dendritic cell (DC) subsets in the breast cancer (BrC) sentinel…”
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Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche by Kos, Kevin, Aslam, Muhammad A., van de Ven, Rieneke, Wellenstein, Max D., Pieters, Wietske, van Weverwijk, Antoinette, Duits, Danique E.M., van Pul, Kim, Hau, Cheei-Sing, Vrijland, Kim, Kaldenbach, Daphne, Raeven, Elisabeth A.M., Quezada, Sergio A., Beyaert, Rudi, Jacobs, Heinz, de Gruijl, Tanja D., de Visser, Karin E.

“…Breast cancer is accompanied by systemic immunosuppression, which facilitates metastasis formation, but how this shapes organotropism of metastasis is poorly…”
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Guidelines for preparation and flow cytometry analysis of human nonlymphoid tissue DC by Dudziak, Diana, Heger, Lukas, Agace, William W, Bakker, Joyce, Gruijl, Tanja D., Dress, Regine J., Dutertre, Charles‐Antoine, Fenton, Thomas M., Fransen, Marieke F., Ginhoux, Florent, Heyman, Oded, Horev, Yael, Hornsteiner, Florian, Kandiah, Vinitha, Kles, Paz, Lubin, Ruth, Mizraji, Gabriel, Prokopi, Anastasia, Saar, Or, Sopper, Sieghart, Stoitzner, Patrizia, Strandt, Helen, Sykora, Martina M, Toffoli, Elisa C., Tripp, Christoph H., Pul, Kim, Ven, Rieneke, Wilensky, Asaf, Yona, Simon, Zelle‐Rieser, Claudia

“…This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state‐of‐the‐art protocols for the preparation, phenotype…”
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Local delivery of low-dose anti-CTLA-4 to the melanoma lymphatic basin leads to systemic Treg reduction and effector T cell activation by van Pul, Kim M, Notohardjo, Jessica C L, Fransen, Marieke F, Koster, Bas D, Stam, Anita G M, Chondronasiou, Dafni, Lougheed, Sinéad M, Bakker, Joyce, Kandiah, Vinitha, van den Tol, M Petrousjka, Jooss, Karin, Vuylsteke, Ronald J C L M, van den Eertwegh, Alfons J M, de Gruijl, Tanja D

“…Preclinical studies show that locoregional CTLA-4 blockade is equally effective in inducing tumor eradication as systemic delivery, without the added risk of…”
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Local delivery of low-dose anti-CTLA-4 to the melanoma lymphatic basin leads to systemic T reg reduction and effector T cell activation by van Pul, Kim M, Notohardjo, Jessica C L, Fransen, Marieke F, Koster, Bas D, Stam, Anita G M, Chondronasiou, Dafni, Lougheed, Sinéad M, Bakker, Joyce, Kandiah, Vinitha, van den Tol, M Petrousjka, Jooss, Karin, Vuylsteke, Ronald J C L M, van den Eertwegh, Alfons J M, de Gruijl, Tanja D

“…Preclinical studies show that locoregional CTLA-4 blockade is equally effective in inducing tumor eradication as systemic delivery, without the added risk of…”
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309 The role of tumor-draining lymph nodes in the tuning of systemic T cell immunity by CTLA-4 blockade is revealed by local delivery of tremelimumab in early-stage melanoma: data from a Phase-I trial by Notohardjo, Jessica, Pul, Kim van, Stam, Anita, Chondronasiou, Dafni, Lougheed, Sinead, Tol, Petrousjka van den, Jooss, Karin, Vuylsteke, Ronald, Eertwegh, Alfons van den, Gruijl, Tanja de

“…BackgroundThe sentinel lymph node (SLN) is the first node to receive lymphatic drainage from the primary tumor and the site where naïve T cells are first…”
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Feasibility of flowcytometric quantitation of immune effector cell subsets in the sentinel lymph node of the breast after cryopreservation by van Pul, Kim M., Vuylsteke, Ronald J.C.L.M., Bril, Herman, Stockmann, Hein B.A.C., de Gruijl, Tanja D.

“…The sentinel lymph node (SLN) is an emerging focus for immunological research in breast cancer. Cryopreservation of SLN single-cell suspensions allows for…”
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Effect of supervised exercise therapy for intermittent claudication in patients with diabetes mellitus by van Pul, Kim M, Kruidenier, Lotte M, Nicolaï, Saskia P A, de Bie, Rob A, Nieman, Fred H M, Prins, Martin H, Teijink, Joep A W

“…Primary treatment for patients with intermittent claudication is exercise therapy. Diabetes mellitus (DM) is a frequently occurring comorbidity in patients…”
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Counteracting breast-cancer induced immune suppression by reactivating lymph node-resident conventional dendritic cells (LNR-cDC) by van de Ven, Rieneke, van Pul, Kim, Aliabadi, Shaghayegh, van den Tol, Petrousjka, te Velde, Lisette A, Rutgers, Emiel JTh, Vuylsteke, Ronald JCLM, Stockmann, Hein BAC, Dubay, Christopher, Harrington, Chris, Fox, Bernard A, de Gruijl, Tanja D

“…Breast cancer (BrC)-derived factors inhibit proper development and activation of dendritic cells (DC), which in turn promote the expansion of regulatory T…”
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Profiling of suppressive immune subsets in metastasis negative and positive sentinel lymph nodes from patients with HER2- breast cancer by van de Ven, Rieneke, van Pul, Kim, Aliabadi, Shaghayegh, van den Tol, M Petrousjka, Haley, Daniel, Tamakawa, Raina, Vuylsteke, Ronald J, Stockmann, Hein B, Cramer, Julie L, Urba, Walter J, Fox, Bernard A, de Gruijl, Tanja D

“…BackgroundSince it is the site of initial immune activation and priming of antigen-specific T cells, as well as the first location to which tumor cells…”
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Tumor-educated T regs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche by Kos, Kevin, Aslam, Muhammad A, van de Ven, Rieneke, Wellenstein, Max D, Pieters, Wietske, van Weverwijk, Antoinette, Duits, Danique E M, van Pul, Kim, Hau, Cheei-Sing, Vrijland, Kim, Kaldenbach, Daphne, Raeven, Elisabeth A M, Quezada, Sergio A, Beyaert, Rudi, Jacobs, Heinz, de Gruijl, Tanja D, de Visser, Karin E

“…Breast cancer is accompanied by systemic immunosuppression, which facilitates metastasis formation, but how this shapes organotropism of metastasis is poorly…”
Get full text