Suchergebnisse - "van Lohuizen, Maarten"

Polycomb silencers control cell fate, development and cancer von Sparmann, Anke, van Lohuizen, Maarten

“… Key Points Epigenetic gene silencing is an important mechanism for the loss of gene function and collaborates with genetic mutation in the initiation and …”
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Chromatin position effects assayed by thousands of reporters integrated in parallel von Akhtar, Waseem, de Jong, Johann, Pindyurin, Alexey V, Pagie, Ludo, Meuleman, Wouter, de Ridder, Jeroen, Berns, Anton, Wessels, Lodewyk F A, van Lohuizen, Maarten, van Steensel, Bas

“… Reporter genes integrated into the genome are a powerful tool to reveal effects of regulatory elements and local chromatin context on gene expression. However, …”
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Multiplexed Cas9 targeting reveals genomic location effects and gRNA-based staggered breaks influencing mutation efficiency von Gisler, Santiago, Gonçalves, Joana P., Akhtar, Waseem, de Jong, Johann, Pindyurin, Alexey V., Wessels, Lodewyk F. A., van Lohuizen, Maarten

“… Understanding the impact of guide RNA (gRNA) and genomic locus on CRISPR-Cas9 activity is crucial to design effective gene editing assays. However, it is …”
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Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells von Smith, Lan-Lan, Yeung, Jenny, Zeisig, Bernd B, Popov, Nikolay, Huijbers, Ivo, Barnes, Josephine, Wilson, Amanda J, Taskesen, Erdogan, Delwel, Ruud, Gil, Jesús, Van Lohuizen, Maarten, So, Chi Wai Eric

“… Bmi1 is required for efficient self-renewal of hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs). In this study, we investigated whether …”
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Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression von de Vries, Nienke A., Hulsman, Danielle, Akhtar, Waseem, de Jong, Johann, Miles, Denise C., Blom, Marleen, van Tellingen, Olaf, Jonkers, Jos, van Lohuizen, Maarten

“… EZH2 is frequently overexpressed in glioblastoma (GBM), suggesting an oncogenic function that could be a target for therapeutic intervention. However, reduced …”
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Stem cell regulation by polycomb repressors: postponing commitment von Pietersen, Alexandra M, van Lohuizen, Maarten

“… Polycomb group proteins (PcGs) are involved in gene repression through chromatin modifications and required for the maintenance of both embryonic and adult …”
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Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation von Peric-Hupkes, Daan, Meuleman, Wouter, Pagie, Ludo, Bruggeman, Sophia W M, Solovei, Irina, Brugman, Wim, Gräf, Stefan, Flicek, Paul, Kerkhoven, Ron M, van Lohuizen, Maarten, Reinders, Marcel, Wessels, Lodewyk, van Steensel, Bas

“… The three-dimensional organization of chromosomes within the nucleus and its dynamics during differentiation are largely unknown. To visualize this process in …”
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In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis von Gargiulo, Gaetano, Cesaroni, Matteo, Serresi, Michela, de Vries, Nienke, Hulsman, Danielle, Bruggeman, Sophia W, Lancini, Cesare, van Lohuizen, Maarten

“… In mouse and human neural progenitor and glioblastoma "stem-like" cells, we identified key targets of the Polycomb-group protein BMI1 by combining ChIP-seq …”
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The many faces of ubiquitinated histone H2A: insights from the DUBs von Vissers, Joseph HA, Nicassio, Francesco, van Lohuizen, Maarten, Di Fiore, Pier Paolo, Citterio, Elisabetta

“… Monoubiquitination of H2A is a major histone modification in mammalian cells. Understanding how monoubiquitinated H2A (uH2A) regulates DNA-based processes in …”
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BMI1 Is Recruited to DNA Breaks and Contributes to DNA Damage-Induced H2A Ubiquitination and Repair von Ginjala, Vasudeva, Nacerddine, Karim, Kulkarni, Atul, Oza, Jay, Hill, Sarah J., Yao, Ming, Citterio, Elisabetta, van Lohuizen, Maarten, Ganesan, Shridar

“… Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley …”
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Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice von Badhai, Jitendra, Pandey, Gaurav Kumar, Song, Ji-Ying, Krijgsman, Oscar, Bhaskaran, Rajith, Chandrasekaran, Gayathri, Kwon, Min-Chul, Bombardelli, Lorenzo, Monkhorst, Kim, Grasso, Cristoforo, Zevenhoven, John, van der Vliet, Jan, Cozijnsen, Miranda, Krimpenfort, Paul, Peeper, Daniel, van Lohuizen, Maarten, Berns, Anton

“… We have generated mouse models of malignant mesothelioma (MM) based upon disruption of the Bap1, Nf2, and Cdkn2ab tumor suppressor loci in various combinations …”
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TRIM28 Is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming von Miles, Denise Catherine, de Vries, Nienke Alexandra, Gisler, Santiago, Lieftink, Cor, Akhtar, Waseem, Gogola, Ewa, Pawlitzky, Inka, Hulsman, Danielle, Tanger, Ellen, Koppens, Martijn, Beijersbergen, Roderick Leonardus, van Lohuizen, Maarten

“… Since the discovery of induced pluripotent stem cells there has been intense interest in understanding the mechanisms that allow a somatic cell to be …”
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Epigenetics and cancer von Lund, Anders H, van Lohuizen, Maarten

“… Epigenetic mechanisms act to change the accessibility of chromatin to transcriptional regulation locally and globally via modifications of the DNA and by …”
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Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells von Koppens, Martijn A J, Bounova, Gergana, Gargiulo, Gaetano, Tanger, Ellen, Janssen, Hans, Cornelissen-Steijger, Paulien, Blom, Marleen, Song, Ji-Ying, Wessels, Lodewyk F A, van Lohuizen, Maarten

“… The polycomb repressive complex 2 (PRC2) regulates differentiation by contributing to repression of gene expression and thereby stabilizing the fate of stem …”
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Structure and E3-ligase activity of the Ring-Ring complex of Polycomb proteins Bmi1 and Ring1b von Buchwald, Gretel, van der Stoop, Petra, Weichenrieder, Oliver, Perrakis, Anastassis, van Lohuizen, Maarten, Sixma, Titia K

“… Polycomb group proteins Ring1b and Bmi1 ( B ‐cell‐specific M oloney murine leukaemia virus i ntegration site 1) are critical components of the chromatin …”
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PRC1 coordinates timing of sexual differentiation of female primordial germ cells von Yokobayashi, Shihori, Liang, Ching-Yeu, Kohler, Hubertus, Nestorov, Peter, Liu, Zichuan, Vidal, Miguel, van Lohuizen, Maarten, Roloff, Tim C., Peters, Antoine H. F. M.

“… The Polycomb repressive complex 1 (PRC1) is found to have important gene-dosage-dependent and sex-specific roles in primordial germ cell (PGC) development, …”
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Functional Anatomy of Polycomb and Trithorax Chromatin Landscapes in Drosophila Embryos von Schuettengruber, Bernd, Ganapathi, Mythily, Leblanc, Benjamin, Portoso, Manuela, Jaschek, Rami, Tolhuis, Bas, van Lohuizen, Maarten, Tanay, Amos, Cavalli, Giacomo

“… Polycomb group (PcG) and trithorax group (trxG) proteins are conserved chromatin factors that regulate key developmental genes throughout development. In …”
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Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster von Tolhuis, Bas, Muijrers, Inhua, de Wit, Elzo, Teunissen, Hans, Talhout, Wendy, van Steensel, Bas, van Lohuizen, Maarten

“… Polycomb group (PcG) proteins maintain transcriptional repression of developmentally important genes 1 and have been implicated in cell proliferation and stem …”
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Interactions among Polycomb Domains Are Guided by Chromosome Architecture von Tolhuis, Bas, Blom, Marleen, Kerkhoven, Ron M., Pagie, Ludo, Teunissen, Hans, Nieuwland, Marja, Simonis, Marieke, de Laat, Wouter, van Lohuizen, Maarten, van Steensel, Bas

“… Polycomb group (PcG) proteins bind and regulate hundreds of genes. Previous evidence has suggested that long-range chromatin interactions may contribute to the …”
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Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos von Terranova, Rémi, Yokobayashi, Shihori, Stadler, Michael B, Otte, Arie P, van Lohuizen, Maarten, Orkin, Stuart H, Peters, Antoine H F M

“… Genomic imprinting regulates parental-specific expression of particular genes and is required for normal mammalian development. How imprinting is established …”
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