Search Results - "van Leeuwen, Fred"

Somatic mutations in neurons during aging and neurodegeneration by Verheijen, Bert M., Vermulst, Marc, van Leeuwen, Fred W.

“…The nervous system is composed of a large variety of neurons with a diverse array of morphological and functional properties. This heterogeneity is essential…”
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Correction to: Somatic mutations in neurons during aging and neurodegeneration by Verheijen, Bert M., Vermulst, Marc, van Leeuwen, Fred W.

“…In the original article, the panels “Brain organoids” and “Transgenics” were included in Fig. 5 without permission…”
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Altered ubiquitin signaling induces Alzheimer’s disease-like hallmarks in a three-dimensional human neural cell culture model by Maniv, Inbal, Sarji, Mahasen, Bdarneh, Anwar, Feldman, Alona, Ankawa, Roi, Koren, Elle, Magid-Gold, Inbar, Reis, Noa, Soteriou, Despina, Salomon-Zimri, Shiran, Lavy, Tali, Kesselman, Ellina, Koifman, Naama, Kurz, Thimo, Kleifeld, Oded, Michaelson, Daniel, van Leeuwen, Fred W., Verheijen, Bert M., Fuchs, Yaron, Glickman, Michael H.

“…Alzheimer’s disease (AD) is characterized by toxic protein accumulation in the brain. Ubiquitination is essential for protein clearance in cells, making…”
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Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling by Hustedt, Nicole, Seeber, Andrew, Sack, Ragna, Tsai-Pflugfelder, Monika, Bhullar, Bhupinder, Vlaming, Hanneke, van Leeuwen, Fred, Guénolé, Aude, van Attikum, Haico, Srivas, Rohith, Ideker, Trey, Shimada, Kenji, Gasser, Susan M

“…Mec1-Ddc2 (ATR-ATRIP) controls the DNA damage checkpoint and shows differential cell-cycle regulation in yeast. To find regulators of Mec1-Ddc2, we exploited a…”
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Patterns and Mechanisms of Ancestral Histone Protein Inheritance in Budding Yeast by Radman-Livaja, Marta, Verzijlbergen, Kitty F., Weiner, Assaf, van Welsem, Tibor, Friedman, Nir, Rando, Oliver J., van Leeuwen, Fred

“…Replicating chromatin involves disruption of histone-DNA contacts and subsequent reassembly of maternal histones on the new daughter genomes. In bulk, maternal…”
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Dysfunction of Protein Quality Control in Parkinsonism–Dementia Complex of Guam by Verheijen, Bert M., Oyanagi, Kiyomitsu, van Leeuwen, Fred W.

“…Guam parkinsonism-dementia complex (G-PDC) is an enigmatic neurodegenerative disease that is endemic to the Pacific island of Guam. G-PDC patients are…”
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Expression of Mutant Ubiquitin and Proteostasis Impairment in Kii Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex Brains by Verheijen, Bert M, Morimoto, Satoru, Sasaki, Ryogen, Oyanagi, Kiyomitsu, Kokubo, Yasumasa, Kuzuhara, Shigeki, van Leeuwen, Fred W

“…Abstract Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) is a progressive neurodegenerative disorder that is endemic to the Kii…”
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Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin by Braun, Ralf J., Sommer, Cornelia, Leibiger, Christine, Gentier, Romina J.G., Dumit, Verónica I., Paduch, Katrin, Eisenberg, Tobias, Habernig, Lukas, Trausinger, Gert, Magnes, Christoph, Pieber, Thomas, Sinner, Frank, Dengjel, Jörn, van Leeuwen, Fred W., Kroemer, Guido, Madeo, Frank

“…Neuronal accumulation of UBB+1, a frameshift variant of ubiquitin B, is a hallmark of Alzheimer’s disease (AD). How UBB+1 contributes to neuronal dysfunction…”
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Dot1-Dependent Histone H3K79 Methylation Promotes Activation of the Mek1 Meiotic Checkpoint Effector Kinase by Regulating the Hop1 Adaptor by Ontoso, David, Acosta, Isabel, van Leeuwen, Fred, Freire, Raimundo, San-Segundo, Pedro A.

“…During meiosis, accurate chromosome segregation relies on the proper interaction between homologous chromosomes, including synapsis and recombination. The…”
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A network model of the molecular organization of chromatin in Drosophila by van Bemmel, Joke G, Filion, Guillaume J, Rosado, Arantxa, Talhout, Wendy, de Haas, Marcel, van Welsem, Tibor, van Leeuwen, Fred, van Steensel, Bas

“…Chromatin governs gene regulation and genome maintenance, yet a substantial fraction of the chromatin proteome is still unexplored. Moreover, a global model of…”
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Epigenetics Identifier screens reveal regulators of chromatin acylation and limited specificity of acylation antibodies by Kollenstart, Leonie, van der Horst, Sophie C., Vreeken, Kees, Janssen, George M. C., Martino, Fabrizio, Vlaming, Hanneke, van Veelen, Peter A., van Leeuwen, Fred, van Attikum, Haico

“…The collection of known posttranslational modifications (PTMs) has expanded rapidly with the identification of various non-acetyl histone lysine acylations,…”
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Deposition of mutant ubiquitin in parkinsonism–dementia complex of Guam by Verheijen, Bert M., Hashimoto, Tomoyo, Oyanagi, Kiyomitsu, van Leeuwen, Fred W.

“…Keywords: Parkinsonism-dementia complex, Guam, Mutant ubiquitin, Ubiquitin-proteasome system, TDP-43…”
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Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1 by Vlaming, Hanneke, Molenaar, Thom M, van Welsem, Tibor, Poramba-Liyanage, Deepani W, Smith, Desiree E, Velds, Arno, Hoekman, Liesbeth, Korthout, Tessy, Hendriks, Sjoerd, Altelaar, AF Maarten, van Leeuwen, Fred

“…Given the frequent misregulation of chromatin in cancer, it is important to understand the cellular mechanisms that regulate chromatin structure. However,…”
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Activation of the Unfolded Protein Response and Proteostasis Disturbance in Parkinsonism-Dementia of Guam by Verheijen, Bert M, Lussier, Celina, Müller-Hübers, Cora, Garruto, Ralph M, Oyanagi, Kiyomitsu, Braun, Ralf J, van Leeuwen, Fred W

“…Abstract Guam parkinsonism-dementia (G-PD) is a progressive and fatal neurodegenerative disorder among the native inhabitants of the Mariana Islands that…”
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Recombination-induced tag exchange to track old and new proteins by Verzijlbergen, Kitty F, Menendez-Benito, Victoria, van Welsem, Tibor, van Deventer, Sjoerd J, Lindstrom, Derek L, Ovaa, Huib, Neefjes, Jacques, Gottschling, Daniel E, van Leeuwen, Fred

“…The dynamic behavior of proteins is critical for cellular homeostasis. However, analyzing dynamics of proteins and protein complexes in vivo has been…”
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A Key Role for Chd1 in Histone H3 Dynamics at the 3′ Ends of Long Genes in Yeast by Radman-Livaja, Marta, Quan, Tiffani K., Valenzuela, Lourdes, Armstrong, Jennifer A., van Welsem, Tibor, Kim, TaeSoo, Lee, Laura J., Buratowski, Stephen, van Leeuwen, Fred, Rando, Oliver J., Hartzog, Grant A.

“…Chd proteins are ATP-dependent chromatin remodeling enzymes implicated in biological functions from transcriptional elongation to control of pluripotency…”
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SETD2: from chromatin modifier to multipronged regulator of the genome and beyond by Molenaar, Thom M., van Leeuwen, Fred

“…Histone modifying enzymes play critical roles in many key cellular processes and are appealing proteins for targeting by small molecules in disease. However,…”
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The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiae by Huseinovic, Angelina, van Leeuwen, Jolanda S., van Welsem, Tibor, Stulemeijer, Iris, van Leeuwen, Fred, Vermeulen, Nico P. E., Kooter, Jan M., Vos, J. Chris

“…Acetaminophen (APAP), although considered a safe drug, is one of the major causes of acute liver failure by overdose, and therapeutic chronic use can cause…”
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The cerebellum in Alzheimer's disease: evaluating its role in cognitive decline by Jacobs, Heidi I L, Hopkins, David A, Mayrhofer, Helen C, Bruner, Emiliano, van Leeuwen, Fred W, Raaijmakers, Wijnand, Schmahmann, Jeremy D

“…The cerebellum has long been regarded as essential only for the coordination of voluntary motor activity and motor learning. Anatomical, clinical and…”
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Dynamic changes in oxytocin receptor expression and activation at parturition in the rat brain by Meddle, Simone L, Bishop, Valerie R, Gkoumassi, Effimia, van Leeuwen, Fred W, Douglas, Alison J

“…Oxytocin plays a pivotal role in rat parturition, acting within the brain to facilitate its own release in the supraoptic nucleus (SON) and paraventricular…”
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