Suchergebnisse - "de Gruijl, Tanja D."

Targeting C‐type lectin receptors: a high‐carbohydrate diet for dendritic cells to improve cancer vaccines von Dinther, Dieke, Stolk, Dorian A., Ven, Rieneke, Kooyk, Yvette, Gruijl, Tanja D., Haan, Joke M. M.

“… Review of in vivo targeting of tumor antigens to lectin receptors on antigen‐presenting cells using antibodies or ligands may improve the antitumor efficacy of …”
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Combination of NK Cells and Cetuximab to Enhance Anti-Tumor Responses in RAS Mutant Metastatic Colorectal Cancer von Veluchamy, John Pradeep, Spanholtz, Jan, Tordoir, Marleen, Thijssen, Victor L., Heideman, Daniëlle A. M., Verheul, Henk M. W., de Gruijl, Tanja D., van der Vliet, Hans J.

“… The ability of Natural Killer (NK) cells to kill tumor targets has been extensively studied in various hematological malignancies. However, NK cell therapy …”
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A Multi-Organ-on-Chip Approach to Investigate How Oral Exposure to Metals Can Cause Systemic Toxicity Leading to Langerhans Cell Activation in Skin von Koning, Jasper J., Rodrigues Neves, Charlotte T., Schimek, Katharina, Thon, Maria, Spiekstra, Sander W., Waaijman, Taco, de Gruijl, Tanja D., Gibbs, Susan

“… Investigating systemic toxicity in vitro is still a huge challenge. Here, a multi-organ-on-chip approach is presented as a typical case of topical exposure of …”
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Transcriptional profiling reveals functional dichotomy between human slan+ non‐classical monocytes and myeloid dendritic cells von Leeuwen‐Kerkhoff, Nathalie, Lundberg, Kristina, Westers, Theresia M., Kordasti, Shahram, Bontkes, Hetty J., Gruijl, Tanja D., Lindstedt, Malin, Loosdrecht, Arjan A.

“… Slan+ non‐classical monocytes are equipped with a distinctive immunological gene set compared to DCs, and harbor monocyte‐like functional features. Human …”
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PD-L1 directed bispecific Vδ2-T cell engager combines lysis of PD-L1 expressing tumor cells with PD-1 immune checkpoint inhibition and modulation of the tumor immune microenvironment von King, Lisa A, Veth, Myrthe, Roos, Marieke, Scheffer, George L, Popovic, Marko A, de Gruijl, Tanja D, van der Vliet, Hans J

“… BackgroundDespite the notable success of programmed death ligand 1 (PD-L1)/programmed death 1 (PD-1) immune checkpoint blockade in cancer, resistance remains a …”
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High-Voltage Electrical Pulses in Oncology: Irreversible Electroporation, Electrochemotherapy, Gene Electrotransfer, Electrofusion, and Electroimmunotherapy von Geboers, Bart, Scheffer, Hester J, Graybill, Philip M, Ruarus, Alette H, Nieuwenhuizen, Sanne, Puijk, Robbert S, van den Tol, Petrousjka M, Davalos, Rafael V, Rubinsky, Boris, de Gruijl, Tanja D, Miklavčič, Damijan, Meijerink, Martijn R

“… This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical oncology to treat solid tumors with irreversible electroporation (IRE) and …”
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Gamma Delta T-Cell Based Cancer Immunotherapy: Past-Present-Future von Saura-Esteller, José, de Jong, Milon, King, Lisa A., Ensing, Erik, Winograd, Benjamin, de Gruijl, Tanja D., Parren, Paul W. H. I., van der Vliet, Hans J.

“… γδ T-cells directly recognize and kill transformed cells independently of HLA-antigen presentation, which makes them a highly promising effector cell …”
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Chemokines modulate glycan binding and the immunoregulatory activity of galectins von Sanjurjo, Lucía, Schulkens, Iris A., Touarin, Pauline, Heusschen, Roy, Aanhane, Ed, Castricum, Kitty C. M., De Gruijl, Tanja D., Nilsson, Ulf J., Leffler, Hakon, Griffioen, Arjan W., Elantak, Latifa, Koenen, Rory R., Thijssen, Victor L. J. L.

“… Galectins are versatile glycan-binding proteins involved in immunomodulation. Evidence suggests that galectins can control the immunoregulatory function of …”
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ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer von Ven, Rieneke, Oerlemans, Ruud, Heijden, Joost W., Scheffer, George L., Gruijl, Tanja D., Jansen, Gerrit, Scheper, Rik J.

“… Review evaluates the possible physiological roles of MDR‐related ABC transporters on immune effector cells based on reports on their expression patterns and …”
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Langerin-mediated internalization of a modified peptide routes antigens to early endosomes and enhances cross-presentation by human Langerhans cells von Fehres, Cynthia M, Duinkerken, Sanne, Bruijns, Sven CM, Kalay, Hakan, van Vliet, Sandra J, Ambrosini, Martino, de Gruijl, Tanja D, Unger, Wendy WJ, Garcia-Vallejo, Juan J, van Kooyk, Yvette

“… The potential of the skin immune system to generate immune responses is well established, and the skin is actively exploited as a vaccination site. Human skin …”
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Immunotherapy Goes Local: The Central Role of Lymph Nodes in Driving Tumor Infiltration and Efficacy von van Pul, Kim M., Fransen, Marieke F., van de Ven, Rieneke, de Gruijl, Tanja D.

“… Immune checkpoint blockade (ICB) has changed the therapeutic landscape of oncology but its impact is limited by primary or secondary resistance. ICB resistance …”
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Prognostic effect of different PD-L1 expression patterns in squamous cell carcinoma and adenocarcinoma of the cervix von Heeren, A Marijne, Punt, Simone, Bleeker, Maaike CG, Gaarenstroom, Katja N, van der Velden, Jacobus, Kenter, Gemma G, de Gruijl, Tanja D, Jordanova, Ekaterina S

“… Programmed death-ligand 1 (PD-L1) is expressed in various immune cells and tumor cells, and is able to bind to PD-1 on T lymphocytes, thereby inhibiting their …”
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Tissue micro array analysis of ganglioside N-glycolyl GM3 expression and signal transducer and activator of transcription (STAT)-3 activation in relation to dendritic cell infiltration and microvessel density in non-small cell lung cancer von van Cruijsen, Hester, Ruiz, Mariëlle Gallegos, van der Valk, Paul, de Gruijl, Tanja D, Giaccone, Giuseppe

“… Background Tumor immune escape and angiogenesis contribute to tumor progression, and gangliosides and activation of signal transducer and activator of …”
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Stereotactic ablative radiotherapy for the comprehensive treatment of 4–10 oligometastatic tumors (SABR-COMET-10): study protocol for a randomized phase III trial von Palma, David A., Olson, Robert, Harrow, Stephen, Correa, Rohann J. M., Schneiders, Famke, Haasbeek, Cornelis J. A., Rodrigues, George B., Lock, Michael, Yaremko, Brian P., Bauman, Glenn S., Ahmad, Belal, Schellenberg, Devin, Liu, Mitchell, Gaede, Stewart, Laba, Joanna, Mulroy, Liam, Senthi, Sashendra, Louie, Alexander V., Swaminath, Anand, Chalmers, Anthony, Warner, Andrew, Slotman, Ben J., de Gruijl, Tanja D., Allan, Alison, Senan, Suresh

“… Background Stereotactic ablative radiotherapy (SABR) has emerged as a new treatment option for patients with oligometastatic disease. SABR delivers precise, …”
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The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments von Veluchamy, John P., Kok, Nina, van der Vliet, Hans J., Verheul, Henk M. W., de Gruijl, Tanja D., Spanholtz, Jan

“… Natural killer (NK) cells are critical immune effector cells in the fight against cancer. As NK cells in cancer patients are highly dysfunctional and reduced …”
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Functional delivery of viral miRNAs via exosomes von Pegtel, D Michiel, Cosmopoulos, Katherine, Thorley-Lawson, David A, van Eijndhoven, Monique A J, Hopmans, Erik S, Lindenberg, Jelle L, de Gruijl, Tanja D, Würdinger, Thomas, Middeldorp, Jaap M

“… Noncoding regulatory microRNAs (miRNAs) of cellular and viral origin control gene expression by repressing the translation of mRNAs into protein …”
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Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression von Baglio, S Rubina, Lagerweij, Tonny, Pérez-Lanzón, Maria, Ho, Xuan Dung, Léveillé, Nicolas, Melo, Sonia A, Cleton-Jansen, Anne-Marie, Jordanova, Ekaterina S, Roncuzzi, Laura, Greco, Michelina, van Eijndhoven, Monique A J, Grisendi, Giulia, Dominici, Massimo, Bonafede, Roberta, Lougheed, Sinead M, de Gruijl, Tanja D, Zini, Nicoletta, Cervo, Silvia, Steffan, Agostino, Canzonieri, Vincenzo, Martson, Aare, Maasalu, Katre, Köks, Sulev, Wurdinger, Tom, Baldini, Nicola, Pegtel, D Michiel

“… Human osteosarcoma is a genetically heterogeneous bone malignancy with poor prognosis despite the employment of aggressive chemotherapy regimens. Because …”
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Unlocking the therapeutic potential of primary tumor-draining lymph nodes von Rotman, Jossie, Koster, Bas D., Jordanova, Ekaterina S., Heeren, A. Marijne, de Gruijl, Tanja D.

“… Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune …”
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Stereotactic ablative radiotherapy for the comprehensive treatment of 1–3 Oligometastatic tumors (SABR-COMET-3): study protocol for a randomized phase III trial von Olson, Robert, Mathews, Lindsay, Liu, Mitchell, Schellenberg, Devin, Mou, Benjamin, Berrang, Tanya, Harrow, Stephen, Correa, Rohann J. M., Bhat, Vasudeva, Pai, Howard, Mohamed, Islam, Miller, Stacy, Schneiders, Famke, Laba, Joanna, Wilke, Derek, Senthi, Sashendra, Louie, Alexander V., Swaminath, Anand, Chalmers, Anthony, Gaede, Stewart, Warner, Andrew, de Gruijl, Tanja D., Allan, Alison, Palma, David A.

“… Background A recent randomized phase II trial evaluated stereotactic ablative radiotherapy (SABR) in a group of patients with a small burden of oligometastatic …”
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Human dendritic cell line models for DC differentiation and clinical DC vaccination studies von Santegoets, Saskia J. A. M., Eertwegh, Alfons J. M., Loosdrecht, Arjan A., Scheper, Rik J., Gruijl, Tanja D.

“… Dendritic cells (DC) are increasingly applied in the immunotherapy of cancer. As the development of a standardized DC vaccine product is often hampered by the …”
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