Suchergebnisse - "de Groot, Daniël"

Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine von Spanjaard, Aldo, Shah, Ronak, de Groot, Daniël, Buoninfante, Olimpia Alessandra, Morris, Ben, Lieftink, Cor, Pritchard, Colin, Zürcher, Lisa M, Ormel, Shirley, Catsman, Joyce J I, de Korte-Grimmerink, Renske, Siteur, Bjørn, Proost, Natalie, Boadum, Terry, van de Ven, Marieke, Song, Ji-Ying, Kreft, Maaike, van den Berk, Paul C M, Beijersbergen, Roderick L, Jacobs, Heinz

“… Crosslink repair depends on the Fanconi anemia pathway and translesion synthesis polymerases that replicate over unhooked crosslinks. Translesion synthesis is …”
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Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation von Spanjaard, Aldo, Stratigopoulou, Maria, de Groot, Daniël, Aslam, Muhammad, van den Berk, Paul C. M., Stappenbelt, Chantal, Ayidah, Matilda, Catsman, Joyce J. I., Pardieck, Iris N., Kreft, Maaike, Arens, Ramon, Guikema, Jeroen E. J., Jacobs, Heinz

“… The development and differentiation of B cells is intimately linked to cell proliferation and the generation of diverse immunoglobulin gene ( Ig ) repertoires …”
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ADARp150 counteracts whole genome duplication von van Gemert, Frank, Drakaki, Alexandra, Lozano, Isabel Morales, de Groot, Daniël, Uiterkamp, Maud Schoot, Proost, Natalie, Lieftink, Cor, van de Ven, Marieke, Beijersbergen, Roderick L, Jacobs, Heinz, te Riele, Hein

“… Impaired control of the G1/S checkpoint allows initiation of DNA replication under non-permissive conditions. Unscheduled S-phase entry is associated with DNA …”
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CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors von Lei, Xin, de Groot, Daniël C., Welters, Marij J. P., de Wit, Tom, Schrama, Ellen, van Eenennaam, Hans, Santegoets, Saskia J., Oosenbrug, Timo, van der Veen, Annemarthe, Vos, Joris L., Zuur, Charlotte L., de Miranda, Noel F. C. C., Jacobs, Heinz, van der Burg, Sjoerd H., Borst, Jannie, Xiao, Yanling

“… CD4 + T cells can "help” or "license” conventional type 1 dendritic cells (cDC1s) to induce CD8 + cytotoxic T lymphocyte (CTL) anticancer responses, as proven …”
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Molecular dependencies and genomic consequences of a global DNA damage tolerance defect von de Groot, Daniel, Spanjaard, Aldo, Shah, Ronak, Kreft, Maaike, Morris, Ben, Lieftink, Cor, Catsman, Joyce J. I., Ormel, Shirley, Ayidah, Matilda, Pilzecker, Bas, Buoninfante, Olimpia Alessandra, van den Berk, Paul C. M., Beijersbergen, Roderick L., Jacobs, Heinz

“… Background DNA damage tolerance (DDT) enables replication to continue in the presence of fork stalling lesions. In mammalian cells, DDT is regulated by two …”
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Identification of the Common Origins of Osteoclasts, Macrophages, and Dendritic Cells in Human Hematopoiesis von Xiao, Yanling, Zijl, Sebastiaan, Wang, Liqin, de Groot, Daniel C., van Tol, Maarten J., Lankester, Arjan C., Borst, Jannie

“… Osteoclasts (OCs) originate from the myeloid cell lineage, but the successive steps in their lineage commitment are ill-defined, especially in humans. To …”
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Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma von Ramirez, Christel F. A., Taranto, Daniel, Ando-Kuri, Masami, de Groot, Marnix H. P., Tsouri, Efi, Huang, Zhijie, de Groot, Daniel, Kluin, Roelof J. C., Kloosterman, Daan J., Verheij, Joanne, Xu, Jing, Vegna, Serena, Akkari, Leila

“… Myeloid cells are abundant and plastic immune cell subsets in the liver, to which pro-tumorigenic, inflammatory and immunosuppressive roles have been assigned …”
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Mammalian life depends on two distinct pathways of DNA damage tolerance von Buoninfante, Olimpia Alessandra, Pilzecker, Bas, Spanjaard, Aldo, de Groot, Daniël, Prekovic, Stefan, Song, Ji-Ying, Lieftink, Cor, Ayidah, Matilda, Pritchard, Colin E J, Vivié, Judith, Mcgrath, Kathleen E, Huijbers, Ivo J, Philipsen, Sjaak, von Lindern, Marieke, Zwart, Wilbert, Beijersbergen, Roderick L, Palis, James, van den Berk, Paul C M, Jacobs, Heinz

“… DNA damage threatens genomic integrity and instigates stem cell failure. To bypass genotoxic lesions during replication, cells employ DNA damage tolerance …”
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Chromosomal Rearrangements and Chromothripsis: The Alternative End Generation Model von de Groot, Daniel, Spanjaard, Aldo, Hogenbirk, Marc A., Jacobs, Heinz

“… Chromothripsis defines a genetic phenomenon where up to hundreds of clustered chromosomal rearrangements can arise in a single catastrophic event. The …”
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Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of diffuse large B-cell lymphoma von Göbel, Camiel, Niccolai, Rachele, de Groot, Marnix H P, Jayachandran, Jayashree, Traets, Joleen, Kloosterman, Daan J, Gregoricchio, Sebastian, Morris, Ben, Kreft, Maaike, Song, Ji-Ying, Azarang, Leyla, Kasa, Eirini, Oskam, Nienke, de Groot, Daniel, Hoekman, Liesbeth, Bleijerveld, Onno B, Kersten, Marie José, Aslam, Muhammad A, van Leeuwen, Fred, Jacobs, Heinz

“… Differentiation of antigen-activated B cells into proproliferative germinal center (GC) B cells depends on the activity of the transcription factors …”
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Molecular dependencies and genomic consequences of a global DNA damage tolerance defect von Groot, Daniel De, Spanjaard, Aldo, Shah, Ronak, Kreft, Maaike, Morris, Ben, Cor Lieftink Sr, Joyce Ji Catsman, Ormel, Shirley, Ayidah, Matilda, Pilzecker, Bas, Buoninfante, Olimpia Alessandra, Paul Cm Van Denberk, Beijersbergen, Roderick L, Jacobs, Heinz

“… DNA damage tolerance (DDT) enables replication to continue in the presence of fork stalling lesions. To determine the molecular and genomic impact of a global …”
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Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair von Shah, Ronak, Aslam, Muhammad Assad, Spanjaard, Aldo, de Groot, Daniel, Zürcher, Lisa M, Altelaar, Maarten, Hoekman, Liesbeth, Pritchard, Colin E J, Pilzecker, Bas, van den Berk, Paul C M, Jacobs, Heinz

“… Abstract The Fanconi anemia (FA) repair pathway governs repair of highly genotoxic DNA interstrand crosslinks (ICLs) and relies on translesion synthesis (TLS) …”
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Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B Cell Lymphoma von Göbel, Camiel, Niccolai, Rachele, de Groot, Marnix H.P., Jayachandran, Jayashree, Traets, Joleen, Morris, Ben, Song, Ji-Ying, Azarang, Leyla, Kasa, Eirini, de Groot, Daniel, Kreft, Maaike, Kersten, Marie José, Aslam, Muhammad A., van Leeuwen, Fred, Jacobs, Heinz

“… Differentiation of antigen-activated B cells into pro-proliferative germinal center (GC) B cells depends on the activity of the transcription factor MYC and …”
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Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma von Ramirez, Christel FA, Taranto, Daniel, Ando-Kuri, Masami, de Groot, Marnix HP, Tsouri, Efi, Huang, Zhijie, de Groot, Daniel, Kluin, Roelof JC, Kloosterman, Daan J, Verheij, Joanne, Xu, Jing, Vegna, Serena, Akkari, Leila

“… Myeloid cells are abundant and plastic immune cell subsets in the liver, to which pro-tumorigenic, inflammatory and immunosuppressive roles have been assigned …”
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Explorer Chemistry: Inside the Atom von De Groot, Daniel

“… De Groot reviews Explorer Chemistry: Inside the Atom from Logal Software …”
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Flatography: Detection of gastrointestinal diseases by faecal gas analysis von de Groot, Evelien F, de Meij, Tim G, Berkhout, Daniel J, van der Schee, Marc P, de Boer, Nanne K

“… Patients presenting with gastro-intestinal symptoms might suffer from a range of possible underlying diseases. An unmet need exists for novel cost-effective, …”
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Black and Nixon von Rosencwaig, Norman, De Groot, Daniel, Murray, Peter J

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