Výsledky vyhledávání - "bioinformatic and algorithmical studies"

Application of Neural Networks for classification of Patau, Edwards, Down, Turner and Klinefelter Syndrome based on first trimester maternal serum screening data, ultrasonographic findings and patient demographics Autor Catic, Aida, Gurbeta, Lejla, Kurtovic-Kozaric, Amina, Mehmedbasic, Senad, Badnjevic, Almir

“…Background The usage of Artificial Neural Networks (ANNs) for genome-enabled classifications and establishing genome-phenotype correlations have been…”
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Machine learning based refined differential gene expression analysis of pediatric sepsis Autor Abbas, Mostafa, EL-Manzalawy, Yasser

“… In general, identified differentially expressed genes (DEGs) can be subject to further downstream analysis for obtaining more biological insights such as determining enriched functional pathways or gene ontologies…”
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Characterization of disease-specific cellular abundance profiles of chronic inflammatory skin conditions from deconvolution of biopsy samples Autor Félix Garza, Zandra C., Lenz, Michael, Liebmann, Joerg, Ertaylan, Gökhan, Born, Matthias, Arts, Ilja C. W., Hilbers, Peter A. J., van Riel, Natal A. W.

“…Background Psoriasis and atopic dermatitis are two inflammatory skin diseases with a high prevalence and a significant burden on the patients. Underlying…”
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Genome-wide association study identifies two loci influencing plasma neurofilament light levels Autor Li, Jie-Qiong, Yuan, Xiang-Zhen, Li, Hai-Yan, Cao, Xi-Peng, Yu, Jin-Tai, Tan, Lan, Chen, Wei-An

“…), and 172 patients with AD. All subjects were restricted to non-Hispanic Caucasian derived from the ADNI cohort and met all quality control (QC) criteria…”
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Exploring and analysing single cell multi-omics data with VDJView Autor Samir, Jerome, Rizzetto, Simone, Gupta, Money, Luciani, Fabio

“…Background Single cell RNA sequencing provides unprecedented opportunity to simultaneously explore the transcriptomic and immune receptor diversity of T and B…”
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Vitamin D related genes in lung development and asthma pathogenesis Autor Kho, Alvin T, Sharma, Sunita, Qiu, Weiliang, Gaedigk, Roger, Klanderman, Barbara, Niu, Simin, Anderson, Chris, Leeder, James S, Weiss, Scott T, Tantisira, Kelan G

“…Background Poor maternal vitamin D intake is a risk factor for subsequent childhood asthma, suggesting that in utero changes related to vitamin D responsive…”
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Unraveling the molecular heterogeneity in type 2 diabetes: a potential subtype discovery followed by metabolic modeling Autor Khoshnejat, Maryam, Kavousi, Kaveh, Banaei-Moghaddam, Ali Mohammad, Moosavi-Movahedi, Ali Akbar

“…Background Type 2 diabetes mellitus (T2DM) is a complex multifactorial disease with a high prevalence worldwide. Insulin resistance and impaired insulin…”
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Clinical analysis of germline copy number variation in DMD using a non-conjugate hierarchical Bayesian model Autor Kozareva, Velina, Stroff, Clayton, Silver, Maxwell, Freidin, Jonathan F., Delaney, Nigel F.

“…Background Detection of copy number variants (CNVs) is an important aspect of clinical testing for several disorders, including Duchenne muscular dystrophy,…”
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Visualization and identification of health space, based on personalized molecular phenotype and treatment response to relevant underlying biological processes Autor Bouwman, Jildau, Vogels, Jack TWE, Wopereis, Suzan, Rubingh, Carina M, Bijlsma, Sabina, van Ommen, Ben

“… This makes the effects of treatment difficult to interpret. Methods A statistical visualization method is presented, which analyses and visualizes the effects of treatment in individual subjects…”
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Investigation of coordination and order in transcription regulation of innate and adaptive immunity genes in type 1 diabetes Autor Gao, Shouguo, Wolanyk, Nathaniel, Chen, Ye, Jia, Shuang, Hessner, Martin J., Wang, Xujing

“…Background Type 1 diabetes (T1D) is an autoimmune disease and extensive evidence has indicated a critical role of both the innate and the adaptive arms of…”
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Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans Autor Das, Swapan Kumar, Sharma, Neeraj Kumar, Zhang, Bin

“… Methods We performed integrative gene network analyses of transcriptomic data in subcutaneous adipose tissue of 99 CA and 37 AA subjects metabolically characterized as non-diabetic, with a range of S I and BMI values…”
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